Preface

ix

Preface to the First Edition

xi

Acknowledgments

xiii

Introduction

xv

The Pathologist as a Specialist in Breast Cancer Care

xv

Consultations and Second Opinions in Breast Pathology

xvi

Progress and Uncertainty in Breast Pathology

xvi

Tissue Microarrays, Gene Expression Profiles, and Breast Pathology

xvii

1

Anatomy and Physiological Morphology

1

2

Abnormalities of Mammary Growth and Development

26

3

Inflammatory and Reactive Tumors

33

4

Specific Infections

71

5

Papilloma and Related Benign Tumors

85

6

Myoepithelial Neoplasms

137

7

Adenosis and Microglandular Adenosis

161

8

Fibroepithelial Neoplasms

187

9

Ductal Hyperplasia: Usual and Atypical

230

10

Precancerous Breast Disease: Epidemiological, Pathological, and Clinical Considerations

264

11

Intraductal Carcinoma

285

12

Invasive Duct Carcinoma: Assessment of Prognosis, Morphologic Prognostic Markers, and Tumor Growth Rate

358

13

Tubular Carcinoma

405

14

Papillary Carcinoma

423

15

Medullary Carcinoma

449

16

Carcinoma with Metaplasia

470

17

Squamous Carcinoma

506

18

Mucinous Carcinoma

515

19

Apocrine Carcinoma

536

20

Mammary Carcinomas with Endocrine Features

551

21

Small Cell (Oat Cell) Carcinoma

556

22

Secretory Carcinoma

563

23

Mammary Carcinoma with Osteoclast-Like Giant Cells

571

24

Cystic Hypersecretory Carcinoma and Cystic Hypersecretory Hyperplasia

581

25

Adenoid Cystic Carcinoma

590

26

Cribriform Carcinoma

606

27

Lipid-Rich Carcinoma

610

28

Glycogen-Rich Carcinoma

612

29

Invasive Micropapillary Carcinoma

616

30

Paget’s Disease of the Nipple

621

31

Lobular Carcinoma In Situ and Atypical Lobular Hyperplasia

637

32

Invasive Lobular Carcinoma

690

33

Unusual Clinical Presentations of Carcinoma

721

34

Metastases in the Breast from Nonmammary Malignant Neoplasms

759

35

Benign Proliferative Lesions of the Male Breast

775

36

Carcinoma of the Male Breast

787

37

Breast Tumors in Children

806

38

Benign Mesenchymal Neoplasms

829

39

Sarcoma

902

40

Lymphoid and Hematopoietic Tumors

959

41

Pathologic Effects of Therapy

984

42

Cutaneous Neoplasms

999

43

The Pathology of Axillary and Intramammary Lymph Nodes

1015

44

Pathologic Examination of Breast and Lymph Node Specimens, Including Sentinel Lymph Nodes

1034

Subject Index

1103