9781405136501

Table of Contents


	Preface	7
	Abbreviations	8
	GENERAL PATHOLOGY
	Introduction
1	The Normal Human Cell	12
2	Fluid Dynamics	14
	Tissue Damage
3	Tissue Types and the Effects of Tissue Damage	16
4	Cell Death	18
5	Harmful Agents in the Environment	20
6	The Effects of Tobacco Alcohol and Other Drugs	22
7	Nutritional Disorders	24
	Inflammation and Immunity
8	The Body�s Natural Defences	26
9	B Cells and Immunoglobulins	28
10	T Cells	30
11	The Major Histocompatibility Complex	32
12	The Reticuloendothelial System	34
13	Acute Inflammation	36
14	Chronic Inflammation	38
15	Wound Healing and Repair	40
16	Infection and Immunodeficiency	42
17	Shock	44
18	Tolerance and Autoimmune Disease	46
19	Hypersensitivity Reactions	48
20	Overview of Inflammation and Immunity	50
	Genetics
21	Cell Division	52
22	Genetic Disease	54
	Neoplasia
23	Disordered Cell Growth	56
24	Basic Concepts in Neoplasia	58
25	Tumorigenesis and Oncogenesis	60
26	Oncogenes and Tumour Suppressor Genes	62
27	Common Carcinoma Histological Subtypes	64
28	Tumour Prognosis and Treatment	66
	SYSTEMS PATHOLOGY
	Multisystems Disease
29	Sarcoidosis and Syphilis	70
30	Wilson�s Disease and Haemochromatosis	72
31	Systemic Vasculitis	74
	Cardiovascular Disease
32	Normal Blood Vessels and Types of Aneurysm	76
33	Congenital Heart Disease	78
34	Systemic Hypertension	80
35	Atherosclerosis	82
36	Ischaemic Heart Disease	85
37	Thrombosis	88
38	Embolism and Disseminated Intravascular Coagulation	91
39	Cardiac Valvular Disease	94
40	Myocardial and Pericardial Disease	96
	Respiratory Disease
41	Pulmonary Vascular Disorders	98
42	Pneumonia	100
43	Bronchiectasis	102
44	Tuberculosis	104
45	Chronic Obstructive Pulmonary Disease	106
46	Fibrosing Alveolitis	108
47	Primary Lung Carcinoma	110
48	Other Tumours of the Lung and Pleura	112
	Gastrointestinal Tract Disease
49	Malabsorption	114
50	Peptic Ulceration and Helicobacter Pylori	116
51	Oesophageal Disease	118
52	Tumours of the Stomach and Small Intestine	120
53	Mechanical Disease of the Gastrointestinal Tract	122
54	Ulcerative Colitis and Crohn�s Disease	124
55	Adenomatous Polyps Colorectal Cancer and Anal Carcinoma	126
	Hepatic and Pancreaticobiliary Disease
56	Normal Liver and the Effects of Liver Damage	128
57	Jaundice Gallstones and Carcinoma of the Gallbladder	130
58	Alcoholic and Non-Alcoholic Liver Disease	132
59	Autoimmune Hepatitis and Cholangiopathies	134
60	Viral Hepatitis	136
61	Cirrhosis	139
62	Acute and Chronic Pancreatitis	142
63	Tumours of the Liver Biliary Tree and Pancreas	144
	Genitourinary Tract Disease
64	Congenital and Inherited Abnormalities of the Kidney and Urinary Tract	146
65	The Nephron and Renal Aspects of Hypertension	148
66	Glomerulonephritis	150
67	Important Types of Glomerulonephritis	152
68	Tubulointerstitial Diseases	154
69	Renal Neoplasms	156
70	Bladder Tumours	158
71	Testicular Cancer	160
72	Prostatic Disease	162
	Gynaecological and Obstetric Disease
73	Ovarian Tumours	164
74	Benign Uterine Conditions	166
75	Uterine Cancer	168
76	Cervical Cancer	170
77	Obstetric Pathology	172
78	Paediatric Tumours	174
	Nervous System Disease
79	Cerebrovascular Accidents	176
80	Cerebrovascular Accident Syndromes	178
81	Raised Intracranial Pressure	179
82	Traumatic Injury and Intracranial Haemorrhage	180
83	Central Nervous System Tumours	182
84	Infections of the Nervous System	184
85	Movement Disorders	186
86	Acquired Disorders of Myelination	188
87	Dementia	190
	Endocrine Disease
88	Pituitary Pathology	192
89	Non-Neoplastic Pathology of the Thyroid	194
90	Thyroid Neoplasms	196
91	Parathyroid Gland Pathology	198
92	Adrenal Pathology	200
93	Diabetes Mellitus	202
	Head and Neck Pathology
94	Head and Neck Pathology	204
	Lymphoreticular Disease
95	Lymphoma	206
96	Myeloma	208
97	Assorted Haematological Conditions	210
	Musculoskeletal Disease
98	Muscle Disorders	212
99	Arthritis	214
100	Miscellaneous Non-Neoplastic Osteoarticular Pathology	216
101	Bone Tumours	218
	Skin Disease
102	Inflammatory Dermatoses	220
103	Benign Skin Tumours	222
104	Malignant Skin Tumours	224
	Breast Disease
105	Benign Breast Disease	226
106	Breast Carcinoma	228
	Self-Assessment
	Case Studies and Questions	230
	Answers	235
	Glossary	240
	Reference Ranges	242
	Index	243