Dedication

v

Acknowledgments

ix

About the Editors

xi

Contributing Authors

xiii

Foreword   Gary R. Lichtenstein, MD, FACP, FACG, AGAF

xv

Preface

xvii

SECTION I

INTRODUCTION TO THE LIFE CYCLE OF INFLAMMATORY BOWEL DISEASE

1

Chapter 1

Epidemiology of the Life Cycle of Inflammatory Bowel Disease   Tine Jess, MD, DrMedSci

3

Chapter 2

Inflammatory Bowel Disease in the Developing World: A Rapid Evolution of Global Epidemiology   Daisy Batista, MD and Joshua Korzenik, MD

17

Chapter 3

Immune Development and Inflammatory Bowel Disease   Lee A. Denson, MD

33

SECTION II

INFLAMMATORY BOWEL DISEASE AND THE PEDIATRIC PATIENT

49

Chapter 4

Why Children Get Inflammatory Bowel Disease   Ernest G. Seidman, MD and Devendra K. Amire, MD

51

Chapter 5

Genetic Influences of Early-Onset Inflammatory Bowel Disease   Robert James Pattison and Subra Kugathasan, MD

67

Chapter 6

Natural History and Prognosis of Pediatric-Onset Inflammatory Bowel Disease   William Faubion, MD

79

Chapter 7

Medication Responsiveness in Children   Michael C. Stephens, MD, FAAP

91

Chapter 8

Bone and Inflammatory Bowel Disease   Francisco A. Sylvester, MD

101

Chapter 9

Inflammatory Bowel Disease and the Adolescent   Robbyn E. Sockolow, MD, Aliza B. Solomon, DO, and Oren L. Koslowe, MD

119

Chapter 10

Transition of Care   John M. Russo, MD and Wallace V. Crandall, MD

127

SECTION III

INFLAMMATORY BOWEL DISEASE AND THE YOUNG ADULT

137

Chapter 11

Inflammatory Bowel Disease and Relationships/Sexual Health; An Overview   Amy B. Trachter, PsyD, PhD

139

Chapter 12

Inflammatory Bowel Disease and Fertility   Kim L Isaacs, MD, PhD

147

Chapter 13

Pregnancy and Postpartum   Sonia Friedman, MD

161

Chapter 14

Maintaining Femininity After Surgery   Maria T, Abreu, MD and Yuki Young, MD

177

SECTION IV

INFLAMMATORY BOWEL DISEASE AND THE ELDERLY

183

Chapter 15

The Effect of Menopause and Other Issues in the Older Patient With Inflammatory Bowel Disease   Sunanda Kane, MD, MSPH, FACG, FACP, AGAF

185

Chapter 16

Inflammatory Bowel Disease and Aging: Special Considerations and Management   Darrell S. Pardi, MD

193

SECTION V

SPECIAL CONSIDERATIONS IN THE MANAGEMENT OF THE INFLAMMATORY BOWEL DISEASE LIFE CYCLE

203

Chapter 17

Chronic Care of Inflammatory Bowel Disease   David T. Rubin, MD, FACG, AGAF

205

Chapter 18

Surgical Treatment of Crohn’s Disease Through the Life Cycle   Sharon L. Stein, MD and Fabrizio Michelassi, MD

215

Chapter 19

Inflammatory Bowel Disease in the Current World: Controversies in Management   Corey A. Siegel, MD

231

Chapter 20

The Changing World of Inflammatory Bowel Disease Management: The Impact of New Therapies on Old Strategies   Ellen J. Scberl, MD, FACP, AGAF

245

Index

261