Table of Contents

 

 

 

 

Contributors

xi

 

Acknowledgments

xxix

 

Preface

xxxi

PART I

CARDIOVASCULAR DISEASE: PAST, PRESENT, AND FUTURE

 

1

A History of the Heart   Mark E. Silverman and Charles F. Wooley

3

2

The Burden of Increasing Worldwide Cardiovascular Disease   Ramachandran S. Vasan, Emelia J. Benjamin, Lisa M. Sullivan, and Ralph B. D’Agostino

17

PART 2

FOUNDATIONS OF CARDIOVASCULAR MEDICINE

 

3

Functional Anatomy of the Heart   Joseph F. Melouf, William D. Edwards, A. Jamil Tajik, and James B. Seward

49

4

Normal Physiology of the Cardiovascular System   Brian D. Hoit and Richard A. Walsh

83

5

Principles of Molecular Cardiology   Robert Roberts

110

6

Molecular and Cellular Biology of the Normal, Hypertrophied, and Failing Heart   Allen M. Samarel and Richard A. Walsh

123

7

Biology of the Vessel Wall   Kathy K. Griendling, David G. Harrison, and R. Wayne Alexander

135

8

Molecular Development of the Heart   Neeru Kaushik, Andy Vessels, Roger R. Markwald, and Bradley B. Keller

155

9

Generic Basis for Cardiovascular Disease   Robert Roberts and Elizabeth McNally

177

10

Tissue Regeneration of the Cardiovascular System and Stem Cells   Arjun Deb, Helmut Drexler, and Victor Dzau

190

PART 3

EVALUATION OF THE PATIENT

 

11

Clinical Practice Guidelines in Cardiovascular Disease   Ira S. Nash

205

12

The History, Physical Examination, and Cardiac Auscultation   Robert A. O’Rourke, James A. Shaver, and Mark E. Silverman

215

13

The Resting Electrocardiogram   Agustin Castellanos, Alberto Interian Jr., and Robert J. Myerburg

294

14

ECG Exercise Filing   Gregory Engel and Victor F. Froelicher

324

15

Cardiac Roentgenography   Robert A. O’Rourke and Robert C. Gilkeson

341

16

Echocardiography   Anthony N. DeMaria and Daniel G. Blanchard

359

17

Cardiac Catheterization, Cardiac Angioqraphy and Coronary Blood Flow and Pressure Measurements   Morton J. Kern and Spencer B. King III

467

18

Coronary Intravascular Ultrasound Imaging   E. Murat Tuzcu, Stephen J. Nicholls, and Steven E. Nissen

525

19

Nuclear Cardiology   Daniel S. Berman, Rory Hachamovitch, Leslee J. Shaw, Sean W. Hayes, and Guido Germano

544

20

Computed Tomography of the Heart   Matthew J. Budoff, Michael Poon, and Giuseppe Maiolino

577

21

Magnetic Resonance Imaging of the Heart   Han W. Kim, Wolfgang G. Rehwald, James A. White, and Raymond J. Kim

607

22

Magnetic Resonance Imaging and Computed Tomography of the Vascular System   Jean-Christophe Cornilly, Valentin Fuster, and Zahi A. Fayad

640

23

Positron Emission Tomography for the Noninvasive Study and Quantitation of Myocardial Blood Flow and Metabolism in Cardiovascular Disease   Heinrkh R. Schelbert

659

PART 4

HEART FAILURE

 

24

Pathophysiology of Heart Failure   Gary S. Francis, Edmund H. Sonnenblick, W.H. Wilson Tang, and Philip Poole-Wilson

691

25

The Epidemiology and Diagnosis of Heart Failure   Owais Dar and Martin R. Cowie

713

26

Diagnosis and Management of Heart Failure   William T. Abraham, Ayesha Hasan, and Philip Poole-Wilson

724

27

Surgical Treatment of Heart Failure, Cardiac Transplantation, and Mechanical Ventricular Support   Michael X. Pharn, Jonathan M. Chen, Gerald J. Berry, Eric A. Rose, and John S. Schroeder

761

PART 5

CARDIOMYOPATHY AND SPECIFIC HEART MUSCLE DISEASES

 

28

Classification of Cardiomyopathies   Barry J. Maron and Gaetano Thiene

793

29

Dilated Cardiomyopathies   Luisa Mestroni, Edward M. Gilbert, Brian D. Lowes, and Michael R. Bristow

803

30

Hypertrophic Cardiomyopathy   Steve R. Ommen, Rick A. Nishimura, and A. Jamil Tajik

822

31

Restrictive, Obliterative and Infiltrative Cardiomyopathies   Brian D. Hoit, and Sanjaya Gupta

851

32

Myocarditis and Specific Cardiomyopathies   Sean P. Pinney and Donna M. Mancini

863

PART 6

RHYTHM AND CONDUCTION DISORDERS

 

33

Genetics of Channelopathies and Clinical Implications   Silvia G. Priori and Carlo Napolitano

885

34

Anatomy of Electrophysiology   Slew Yen Ho and Anton E. Becker

898

35

Mechanisms of Cardiac Arrhythmias and Conduction Disturbances   Charles Antzelevitch

913

36

Approach to the Patient with Cardiac Arrhythmias   Eric N. Prystowsky and Richard I. Fogel

946

37

Atrial Fibrillation, Atrial Flutter, and Atrial Tachycardia   Eric N. Prystowsky and Albert L. Waldo

953

38

Supraventricular Tachycardia: AV Nodal Reentry and Wolff-Parkinson - White Syndrome   Hugh Calkins

983

39

Ventricular Arrhythmias   Robert W. Rho and Richard I. Page

1003

40

Bradyarrhythmias and Pacemakers   Pugazhendhi Vijayaraman and Kenneth A. Ellenbogen

1020

41

Long-Term Continuous Electrocardiographs Recording   Eric N. Prystowsky and Benzy J. Padanilam

1055

42

Techniques of Electrophysiologic Evaluation   Masood Akhtar

1064

43

Antiarrhythmic Drugs   Peter R. Kowey, Gan-Xin Van, and Harry Crijns

1077

44

Treatment of Cardiac Arrhythmias with Catheter-Ablative Techniques   Usha B. Tedrow and William G. Stevenson

1095

45

indications and Techniques of Electrical Defibrillation and Cardioversion   Richard E. Kerber

1102

46

The Implantable Cardioverter Defibrilator   Christian Wolpert and Martin Borggrefe

1109

47

Pediatric Arrhythmias   Ronald J. Kanter and Timothy Knilans

1121

PART 7

SYNCOPE, SUDDEN DEATH, AND CARDIOPULMONARY RESUSCITATION

 

48

Diagnosis and Management of Syncope   Mark D. Carlson and Blair P. Grubb

1145

49

Sudden Cardiac Death   Matthew R. Reynolds, Duarte S. Pinto, and Mark E. Josephson

1161

50

Cardiopulmonary and Cardiocerebral   Gordon A. Ewy

1187

PART 8

CORONARY HEART DISEASE

 

SECTION 1

PATHOPHYSIOLOGY AND PREVENTION OF CORONARY HEART DISEASE

 

51

Preventive Strategies for Coronary Heart Disease   David J. Maron, Paul M. Ridker, Scott M. Grundy, and Thomas A. Pearson

1203

52

Atherothrombosis: Role of Inflammation   Prediman K. Shah, Erling balk, and Valentin Fuster

1235

53

Coronary Thrombosis; Local and Systemic Factors   Juan Jose Badimon, Borja Ibanez, Valentin Fuster, and Lina Badimon

1245

54

Coronary Blood Flow and Myocardial Ischemia   Christophe Depre, Stephen E. Vainer, and Garrett J. Gross

1259

55

Nonatherosclerotic Coronary Heart Disease   Bruce E. Waller

1277

56

Definitions of Acute Coronary Syndromes   Michael C. Kim, Annapoorna S. Kini, and Valentin Fuster

1311

57

Pathology of Myocardial Ischemia, Infarction, Reperfusion, and Sudden Death   Allen P. Burke and Renu Virmani

1321

58

Molecular and Cellular Mechanisms of Myocardial Ischemia—Reperfusion Injury   Cyril Ruwende, Scott Visovatti, and David J. Pinsky

1339