Table of Contents

 

 

 

PART I

LABORATORY PRINCLPLES

1

1

Introduction to Clinical Chemistry and Evidence Based Laboratory Medicine

1

2

Introduction to Principles of Laboratory Analyses and Safety

19

3

Specimen Collection and Other Preanalytical Variables

42

PART II

ANALYTICAL TECHNIQUES AND INSTRUMENTATION

63

4

Optical Techniques

62

5

Electrochemistry and Chemical Sensors

84

6

Electrophoresis

102

7

Chromatography

112

8

Mass Spectrometry

128

9

Principles of Clinical Enzymology

140

10

Principles of Immunochemical Techniques

155

11

Automation in the Clinical Laboratory

171

12

Point-of-Care Testing

188

PART III

LABORATORY OPERATIONS

201

13

Selection and Analytical Evaluation of Methods—With Statistical Techniques

201

14

Establishment and Use of Reference Values

229

15

Clinical Laboratory Informatics

239

16

Quality Management

249

PART IV

ANALYTES

263

17

Nucleic Acids

263

18

Amino Acids and Proteins

286

19

Enzymes

317

20

Tumor Markers

337

21

Creatinine, Urea, and Uric Acid

363

22

Carbohydrates

373

23

Lipids, Lipoproteins, Apolipoproteins, and Other Cardiovascular Risk Factors

402

24

Electrolytes and Blood Gases

431

25

Hormones

450

26

Catecholamines and Serotonin

460

27

Vitamins and Trace Elements

476

28

Hemoglobin, Iron, and Bilirubin

509

29

Porphyrins and Disorders of Porphyrin Metabolism

527

30

Therapeutic Drugs

539

31

Clinical Toxicology

562

32

Toxic Metals

603

PART V

PATHOPHYSILOGY

614

33

Cardiovascular Disease

614

34

Kidney Function and Disease

631

35

Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism

655

36

Liver Disease

675

37

Gastrointestinal Disease

696

38

Disorders of Bone

711

39

Pituitary Disorders

735

40

Adrenal Cortical Disorders

749

41

Thyroid Disorders

766

42

Reproductive Disorders

780

43

Disorders of Pregnancy

802

44

Newborn Screening

825

PART VI

REFERENCE INFORMATION

836

45

Reference Information for the Clinical Laboratory

836

Appendix

Review Questions

874

 

Glossary

886