Preface

vii

Acknowledgments

ix

SECTION I

FUNDAMENTAL PRINCIPLES OF PHARMACOLOGY

1

1

Drug-Receptor Interactions

3

2

Pharmacodynamics

7

3

Pharmacokinetics

11

4

Drug Metabolism

15

5

Drug Toxicity

19

Answers to Section 1

22

SECTION II

PRINCIPLES OF NEUROPHARMACOLOGY

29

6

Principles of Cellular Excitability and Electrochemical Transmission

31

7

Principles of Nervous System Physiology and Pharmacology

35

8

Cholinergic Pharmacology

39

9

Adrenergic Pharmacology

43

10

Local Anesthetic Pharmacology

47

11

Pharmacology of GABAergic and Glutamatergic Neurotransmission

51

12

Pharmacology of Dopaminergic Neurotransmission

55

13

Pharmacology of Serotonergic and Central Adrenergic Neurotransmission

59

14

Pharmacology of Abnormal Electrical Neurotransmission in the Central Nervous System

63

15

General Anesthetic Pharmacology

67

16

Pharmacology of Analgesia

71

17

Pharmacology of Drug Dependence and Addiction

75

Answers to Section 2

79

SECTION III

PRINCIPLES OF CARDIOVASCULAR PHARMACOLOGY

95

18

Pharmacology of Cardiac Rhythm

97

19

Pharmacology of Cardiac Contractility

101

20

Pharmacology of Volume Regulation

105

21

Pharmacology of Vascular Tone

109

22

Pharmacology of Hemostasis and Thrombosis

113

23

Pharmacology of Cholesterol and Lipoprotein Metabolism

119

24

Integrative Cardiovascular Pharmacology: Hypertension, Ischemic Heart Disease, and Heart Failure

125

Answers to Section 3

130

SECTION IV

PRINCIPLES OF ENDOCRINE PHARMACOLOGY

141

25

Pharmacology of the Hypothalamus and Pituitary Gland

143

26

Pharmacology of the Thyroid Gland

147

27

Pharmacology of the Adrenal Cortex

151

28

Pharmacology of Reproduction

155

29

Pharmacology of the Endocrine Pancreas

159

30

Pharmacology of Bone Mineral Homeostasis

163

Answers to Section 4

167

SECTION V

PRINCIPLES OF CHEMOTHERAPY

175

31

Principles of Antimicrobial and Antineoplastic Pharmacology

177

32

Pharmacology of Bacterial Infections: DNA Replication, Transcription, and Translation

181

33

Pharmacology of Bacterial Infections: Cell Wall Synthesis

185

34

Pharmacology of Fungal Infections

189

35

Pharmacology of Parasitic Infections

193

36

Pharmacology of Viral Infections

197

37

Pharmacology of Cancer: Genome Synthesis, Stability, and Maintenance

201

38

Pharmacology of Cancer: Signal Transduction

205

39

Principles of Combination Chemotherapy

209

Answers to Section 5

212

SECTION VI

PRINCIPLES OF INFLAMMATION AND IMMUNE PHARMACOLOGY

221

40

Principles of Inflammation and the Immune System

223

41

Pharmacology of Eicosanoids

227

42

Histamine Pharmacology

233

43

Pharmacology of Hematopoiesis and Irnmunomodulation

237

44

Pharmacology of Immunosuppression

241

45

Integrative Inflammation Pharmacology: Peptic Ulcer Disease

245

46

Integrative Inflammation Pharmacology: Asthma

249

47

Integrative Inflammation Pharmacology: Gout

253

Answers to Section 6

256

SECTION VII

FUNDAMENTALS OF DRUG DEVELOPMENT AND REGULATION

265

48

Drug Discovery and Preclinical Development

267

49

Clinical Drug Evaluation and Regulatory Approval

271

50

Systematic Detection of Adverse Events in Marketed Drugs

275

Answers to Section 7

278

SECTION VIII

POISONING BY DRUGS AND ENVIRONMENTAL TOXINS

281

51

Poisoning by Drugs and Environmental Toxins

283

Answers to Section 8

285

SECTION IX

FRONTIERS IN PHARMACOLOGY

287

52

Pharmacogenomics

289

53

Protein-Based Therapies

293

54

Drug Delivery Modalities

297

Answers to Section 9

300