Preface

vii

Contributors

ix

Acknowledgments

xi

SECTION I

PRINCIPLES OF PHARMACOLOGY

1

Introduction to Pharmacology

3

2

Pharmacokinetics

6

3

Pharmacodynamics

14

4

Drug Dosing and Prescription Writing

20

SECTION II

AUTONOMIC NERVOUS SYSTEM

5

Introduction to Autonomic Nervous System Pharmacology

29

6

Cholinergic Agonists

34

7

Cholinergic Antagonists

43

8

Adrenergic Agonists

51

9

Adrenergic Antagonists

62

SECTION III

CENTRAL NERVOUS SYSTEM

10

Introduction to Central Nervous System Pharmacology

75

11

Anxiolytics, Hypnotics, and Sedatives

77

12

Antipsychotics

84

13

Drugs Used to Treat Depression and Mania

91

14

Anticonvulsants

99

15

Drugs Used to Treat CNS Degenerative Disorders

111

16

Anesthetics

120

17

CNS Stimulants

135

18

Alcohol and other Drugs of Abuse

139

19

Opioid Analgesics and Antagonists

145

SECTION IV

CARDIOVASCULAR SYSTEM

20

Antihypertensive Drugs

157

21

Antiarrhythmic Drugs

172

22

Drugs Used to Treat Congestive Heart Failure

187

23

Diuretics

194

24

Antianginal Drugs

202

25

Anticoagulant, Fibrinolytic, and Antiplatelet Drugs

208

26

Antihyperlipidemic Drugs

220

27

Agents Used to Treat Anemia

228

SECTION V

RESPIRATORY SYSTEM

28

Drugs Used to Treat Asthma, Coughs, and Colds

235

SECTION VI

ENDOCRINE SYSTEM

29

Hypothalamic and Pituitary Hormones

245

30

Thyroid and Antithyroid Drugs

250

31

Sex Steroids and Reproductive Drugs

256

32

Corticosteroids and Inhibitors

270

33

Insulins and Oral Hypoglycemic Drugs

277

34

Drugs that Affect Calcium Homeostasis and Bone Metabolism

286

SECTION VII

MUSCULOSKELETAL SYSTEM

35

Anti-Inflammatory Drugs and Acetaminophen

293

36

Drugs Used to Treat Gout

306

37

Autacoids and Autacoid Antagonists

313

SECTION VIII

GASTROINTESTINAL SYSTEM

38

Drugs Used to Treat Gastrointestinal Disorders

321

SECTION IX

IMMUNE SYSTEM

39

Antineoplastic Drugs

333

40

Immunomodulators

359

SECTION X

ANTIMICROBIAL DRUGS

41

Introduction to Antimicrobial Drugs

371

42

Penicillins

375

43

Cephalosporins and other Cell Wall Synthesis Inhibitors

381

44

Protein Synthesis Inhibitors

390

45

Quinolones and Drugs Used to Treat Urinary Tract Infections

402

46

Folate Antagonists

406

47

Antifungal Drugs

411

48

Antiprotozoal Drugs

421

49

Anthelmintic Drugs

437

50

Antiviral Drugs

444

51

Drugs Used to Treat Tuberculosis and Leprosy

462

SECTION XI

TOXICOLOGY

52

Toxicology

471

53

Pharmacology Power Review

493

APPENDICES

A

Sample Problems

555

B

Recommended Antimicrobial Agents Against Selected Organisms

558

Index

565