Contributors

vii

Preface

xiii

Acknowledgments

xv

SECTION I

INTRODUCTION

1

1

The Immune System   William E. Paul

1

SECTION II

ORGANIZATION AND EVOLUTION OF THE IMMUNE SYSTEM

27

2

Lymphoid Tissues and Organs   Eitan Al Akirav, Shan Liao, and Nancy H. Ruddle

27

3

Evolution of the Immune System   Martin F. Flajnik and Louis Du Pasquier

56

SECTION III

IMMUNOGLOBULINS AND B LYMPHOCYTES

125

4

Immunoglobulins: Structure and Function   Harry W. Schroeder, Jr., David Wald, and Neil S. Greenspan

125

5

Antigen–Antibody Interactions and Monoclonal Antibodies   Jay A. Berzofsky, Ira J. Berkower, and Suzanne L. Epstein

152

6

Immunoglobulins: Molecular Genetics   Edward Max

192

7

B Lymphocyte Development and Biology   Richard R. Hardy

237

8

B Lymphocyte Signaling Mechanisms and Activation   Anthony L. DeFranco

270

9

B Lymphocyte Biology   Michael McHeyzer-Williams

289

SECTION IV

T LYMPHOCYTES

313

10

T Cell Antigen Receptors   Mark M. Davis and Yueh-Hsiu Chien

323

11

T Lymphocyte Signaling Mechanisms and Activation   Gary A. Koretzky

346

12

Development of T Cells   Ellen V. Rothenberg and Mary A. Yui

376

13

Peripheral T Lymphocyte Responses and Function   Steven L. Reiner

407

SECTION V

THE INTERSECTION OF INNATE AND ADAPTIVE IMMUNITY

427

14

The Innate Immune System   Ruslan Medzhitov

427

15

Dendritic Cells   Muriel Moser

451

16

Natural Killer Cells   Wayne M. Yokoyama

483

17

NKT Cells and Other Innatelike T and B Lineages   Albert Bendelac

518

18

Macrophages and Phagocytosis   Siamon Gordon

547

19

Major Histocompatibility Complex (MHC) Molecules: Structure, Function, and Genetics   David H. Margulies, Kannan Natarajan, Jamie Rossjohn, and James McCluskey

570

20

Cell Biology of Antigen Processing and Presentation   Lilia Delamarre and Ira Mellman

614

SECTION VI

REGULATION AND EFFECTOR FUNCTIONS OF THE IMMUNE RESPONSE

631

21

Immunogenicity and Antigen Structure   Jay A. Berzofsky and Ira J. Berkower

631

22

Fc Receptors and their Role in Immune Regulation and Inflammation   Jeffrey V. Ravetch and Falk Nimmerjahn

684

23

Type I Cytokines and Interferons and their Receptors   Warren J. Leonard

706

24

Interleukin-1 Family of Ligands and Receptors   Charles A. Dinarello

750

25

TNF-Related Cytokines in Immunity   Carl E. Ware

776

26

Chemokines   Philip M. Murphy

804

27

Programmed Cell Death   Nicolas Bidere, Helen C. Su, and Michael J. Lenardo

834

28

Immunologic Memory   Stephen P. Schoenberger and Shane Crotty

862

29

Immunologic Tolerance   Ronald H. Schwartz

898

30

Regulatory/Suppressor T Cells   Ethan M. Shevach

943

31

The Mucosal Immune System   Hiroshi Kiyono, Jun Kunisawa, Jerry R. McGhee, and Jiri Mestecky

983

32

Neural Immune Interactions   Jeanette. I. Webster Marketon and Esther M. Sternberg

1031

33

Complement   Cornelia Speth, Wolfgang M. Prodinger, Reinhard Würzner, Heribert Stoiber, and Manfred P. Dierich

1047

34

Cytotoxic T Lymphocytes   R. Chris Bleackley

1079

35

The Immune Response to Parasites   David L. Sacks, Alan Sher, Eleanor M. Riley, and Thomas A. Wynn

1097

SECTION VII

IMMUNITY TO INFECTIOUS AGENTS

1097

36

Immunity to Viruses   Hildegund Ertl

1131

37

Immune Responses to Intracellular Bacteria   Eric Pamer

1165

38

Immunity to Extracellular Bacteria   Jeffrey N. Weiser and Moon H. Nahm

1182

39

Immunology of HIV Infection   Norman L. Letvin

1204

40

Vaccines   G.J.V. Nossal

1233

SECTION VIII

IMMUNOLOGIC MECHANISMS IN DISEASE

1291

41

Systemic Autoimmunity   Betty Diamond

1291

42

Organ-Specific Autoimmunity   Matthias G. von Herrath and Dirk Homann

1331

43

Immunological Mechanisms of Allergic Disease   Marsha Wills-Karp

1375

44

Transplantation Immunology   Megan Sykes, Kathryn Wood, and David H. Sachs

1426

45

Tumor Immunology   Nicholas P. Restifo, Paul E Robbins, and Steven A. Rosenberg

1489

46

Primary Immunodeficiency Diseases   Rebecca H. Buckley

1523

Index

1553