Contributing Authors to the Second Edition

ix

Contributing Authors to the First Edition

xi

Preface

xiii

PART 1

FUNDAMENTALS OF NEUROPHARMACOLOGY

1

Basic Principles of Neuropharmacology

3

2

Cellular Basis of Communication

16

3

Synaptic Transmission

55

4

Signal Transduction in the Brain

74

PART 2

NEURAL SUBSTRATES OF DRUG ACTION

5

Excitatory and Inhibitory Amino Acids

117

6

Widely Projecting Systems: Monoamines, Acetylcholine, and Orexin

145

7

Neuropeptides

181

8

Atypical Neurotransmitters

199

PART 3

NEUROPHARMACOLOGY OF NEURAL SYSTEMS AND DISORDERS

9

Autonomic Nervous System

227

10

Neural and Neuroendocrine Control of the Internal Milieu

246

11

Pain and Inflammation

269

12

Sleep and Arousal

289

13

Higher Cognitive Function and Behavioral Control

313

14

Mood and Emotion

335

15

Reinforcement and Addictive Disorders

364

16

Schizophrenia and Other Psychoses

389

17

Neurodegeneration

409

18

Seizure Disorders

443

19

Stroke and Migraine

457

Index

475