Contributors

vii

Preface

xi

UNIT I

GENERAL PRINCIPLES OF TOXICOLOGY

1

1

History and Scope of Toxicology   Michael A. Gallo

1

2

Principles of Toxicology   David L. Eaton and Steven G. Gilbert

5

3

Mechanisms of Toxicity   Zoltán Gregus

21

4

Risk Assessment   Elaine M. Faustman and Gilbert S. Omenn

47

UNIT 2

DISPOSITION OF TOXICANTS

57

5

Absorption, Distribution, and Excretion of Toxicants   Lois D. Lehman-McKeeman

57

6

Biotransformation of Xenobiotics   Andrew Parkinson and Brian W. Ogilvie

71

7

Toxicokinetics Danny D. Shen

99

UNIT 3

NONORGAN-DIRECTED TOXICITY

109

8

Chemical Carcinogenesis   James E. Klaunig and Lisa M. Kamendulis

109

9

Genetic Toxicology   R. Julian Preston and George R. Hoffmann

123

10

Developmental Toxicology   John M. Rogers and Robert J. Kavlock

135

UNIT 4

TARGET ORGAN TOXICITY

147

11

Toxic Responses of the Blood   John C. Bloom and John T. Brandt

147

12

Toxic Responses of the Immune System   Norbert E. Kaminski, Barbara L. Faubert Kaplan, and Michael P. Holsapple

161

13

Toxic Responses of the Liver   Hartmut Jaeschke

177

14

Toxic Responses of the Kidney   Rick G. Schnellmann

191

15

Toxic Responses of the Respiratory System   Hanspeter R. Witschi, Kent E. Pinkerton, Laura S. Van Winkle, and Jerold A. Last

203

16

Toxic Responses of the Nervous System   Virginia C. Moser, Michael Aschner, Rudy J. Richardson, and Martin A. Philbert

217

17

Toxic Responses of the Ocular and Visual System   Donald A. Fox and William K. Boyes

233

18

Toxic Responses of the Heart and Vascular System   Y. James Kang

247

19

Toxic Responses of the Skin   Robert H. Rice and Theodora M. Mauro

267

20

Toxic Responses of the Reproductive System   Paul M.D. Foster and L. Earl Gray Jr.

279

21

Toxic Responses of the Endocrine System   Charles C. Capen

293