Dedication

vii

Contributors

ix

Introduction

xv

Preface to the Fifth Edition

xxii

Preface to the Fourth Edition

xxiv

Preface to the Third Edition

xxvi

Preface to the Second Edition

xxviii

Preface to the First Edition

xxix

1

Classification and Diagnosis of Anemia in Children

1

2

Anemia during the Neonatal Period

14

3

Iron-Deficiency Anemia

38

4

Megaloblastic Anemia

58

5

Hematologic Manifestations of Systemic Illness

87

6

Bone Marrow Failure

123

7

Red Cell Membrane and Enzyme Defects

168

8

Hemoglobinopathies

200

9

Extracorpuscular Hemolytic Anemia

247

10

Polycythemia

257

11

Disorders of White Blood Cells

272

12

Disorders of Platelets

321

13

Hemostatic Disorders

378

14

Thrombotic Disorders

419

15

Lymphadenopathy and Splenomegaly

467

16

Lymphoproliferative Disorders, Myelodysplastic Syndromes and Myeloproliferative Disorders

472

17

Leukemias

575

18

Histiocytosh Syndromes

567

19

Hodgkin Lymphoma

599

20

Non-Hodgkin Lymphoma

624

21

Central Nervous System Malignancies

647

22

Neuroblastoma

671

23

Renal Tumors

695

24

Rhabdomyosarcoma and Other Soft-Tissue Sarcomas

775

25

Malignant Bone Tumors

739

26

Retinoblastoma

759

27

Germ Cell Tumors

776

28

Hepatic Tumors

796

29

Hematopoietic Stem Cell Transplantation

806

30

Management of Oncologic Emergencies

839

31

Supportive Care of Patients with Cancer

857

32

Evaluation, Investigations and Management of Late Effects of Childhood Cancer

927

33

Psychosocial Aspects of Cancer for Children and their Families

952

Appendix 1

Hematological Reference Values

969

Appendix 2

Biological Tumor Markers

995

Appendix 3

Pharmacologic Properties of Commonly used Anticancer Drugs

997

Index

1005