Contributors

ix

Introduction   Andres Lozano and Francisco Ponce

xi

PART I

THE NEUROMODULATION APPROACH

1

The Neuromodulation Approach   Jeffrey E. Arle, MD, PhD

3

PART II

REGIONS OF APPLICATION

2

Cerebral – Surface   Sergio Canavero, MD (US FMCEMS)

19

Commentary on Cerebral – Surface   Beatrice Cioni, MD

43

3

Cerebral – Deep   Yakov Gologorsky, MD and Ron Aiterman, MD

47

Commentary on Cerebral – Deep   Joachim K. Krauss, MD

69

4

Spinal – Extradural   Timothy R. Deer, MD and Mathew Shocket, MD

73

Commentary on Spinal – Extradural   Jeffrey E. Arle, MD, PhD

92

5

Peripheral Nerve   Konstantin V. Slavin, MD

95

Commentary on Peripheral Nerve   Jeffrey E. Arle, MD, PhD

107

PART III

THE NEUROMODULATION THERAPY INTERFACE

6

The Electrode – Materials and Configurations   Daniel R. Merrill, PhD

109

Commentary on The Electrode – Materials and Configurations   Mark Stecker, PhD, MD

147

7

The Electrode – Principles of the Neural Interface: Axons and Cell Bodies   Cameron C. Mclntyre, PhD

153

Commentary: Considerations for Quantitative Modeling of Excitation and Modulation of CNS neurons   Warren M. Grill, PhD

162

8

The Electrode – Principles of the Neural Interface: Circuits   Erwin B. Montgomery Jr, MD

169

Commentary on The Electrode – Principles of the Neural Interface: Circuits   Mark Stecker, PhD, MD

191

9

Device Materials, Handling, and Upgradability   John Kast, BSME, Cabi Molnar, MS and Mark Lent, BSME, MSMOT

193

Commentary on Device Materials, Handling, and Upgradability   Jay L. Shils, PhD

209

10

Electronics   Emarit Ranu, MSEE, MSBS, EMT–B

213

Commentary on Electronics   Henricus Louis journee, MD, PhD

244

11

Power   Tracy Cameron, PhD, Ben Tranchina, MSEE and John Erickson, BSEE

253

Commentary on Power   jay L. Shils, PhD

266

PART IV

PLACING NEUROMODULATION IN THE HUMAN BODY

12

Surgical Techniques   Jeffrey E. Arle, MD, PhD

271

Commentary on Surgical Techniques   Phillip Starr, MD, PhD

281

13

Trials and Their Applicability   Louis J. Raso, MD

283

Commentary on Trials and Their Applicability   Y. Eugene Mironer, MD

295

14

Limiting Morbidity   Konstantin V. Slavin, MD

301

Commentary on Limiting Morbidity   Alon Y. Mogilner, MD, PhD

321

PART V

TROUBLESHOOTING AND REPAIR

15

Intraoperative Evaluation   Jay L Shils, PhD and Jeffrey E. Arle, MD, PhD

327

Commentary on Intraoperative Evaluation   Jeffrey E. Arle, MD, PhD

346

PART VI

POSTOPERATIVE MANAGEMENT

16

Programming–DBS Programming   Jay L Shils, PhD

351

Commentary on Programming – DBS Programming   Jeffrey E. Arle, MD, PhD

372

17

Programming – SCS   Cabi Molnar, MS, Lisa Johanek, PhD, Steve Goetz, MS and John Heitman, BS

375

Commentary on Programming – SCS   Richard B. North, MD

395

18

Safety Concerns and Limitations   Paul S. Larson, MD andAlastair J. Martin, PhD

397

Commentary on Safety Concerns and Limitations   Ali Rezai and Jeffrey E. Arle, MD, PhD

411

PART VII

THE END USER

19

Expectations and Outcomes   Guillermo A. Monsalve, MD, Chad W. Farley, MD and George T. Mandybur, MD

415

Commentary on Expectations and Outcomes   Chris Hart, BA

429

20

Neuromodulation Perspectives   Alim Louis Benabid, MD, PhD

435

Commentary on Neuromodulation Perspectives   Erwin B. Montgomery jr., MD

451

Appendix

465

Index

483