Table
of Contents
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Foreword Olavi Pelkonen |
ix |
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List of Contributors |
xi |
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SECTION 1 |
GENERAL |
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1 |
Introduction Ramesh C.
Gupta |
3 |
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2 |
Reproductive
Anatomy and Physiology Timothy J.
Evans and Vekataseshu
K. Ganjam |
7 |
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3 |
Bio-Communication
Between Mother and Offspring Etsuko Wada and Keiji Wada |
33 |
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4 |
Pharmacokinetics
in Pregnancy Gregory J.
Anger, Maged
M. Costantine, and Mkheline Piquette-Miller |
39 |
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5 |
PBPK Models
in Reproductive and Developmental Toxicology Kannan Krishnan |
47 |
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6 |
Transfer of
Drugs and Xenobiotics
through Milk Aríuro Anadón, Maria Rosa Martínez-Larranaga,
Eva Ramos and Victor Castellano |
57 |
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SECTION 2 |
SAFETY EVALUATION AND TOXICITY TESTING MODELS |
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7 |
Postmarket Surveillance and
Regulatory Considerations in Reproductive and Developmental Toxicology: An FDA
Perspective Susan Bright |
75 |
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8 |
Reproductive
and Developmental Safety Evaluation of New Pharmaceutical Compounds Ramesh C.
Garg, William M. Bracken and Alan M. Hoberman |
89 |
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9 |
Relevance
of Animal Testing and Sensitivity of Endpoints in Reproductive and
Developmental Toxicity Efstathios Nikolaidis |
111 |
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10 |
OECD
Guidelines and Validated Methods for in Vivo Testing of Reproductive
Toxicity Carmen Estevan Martínez, David Patnies, Miguel Angel Sogorb and
Eugenia Vilanova |
123 |
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11 |
Mechanism-Based
Models in Reproductive and Developmental Toxicology David Pamies, Carmen Estevan Martínez, Miguel
A. Sogorb and Eugenia Vilanova |
135 |
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12 |
In Vitro Embryotoxicity Testing Vadim Popov and Galina Protasova |
147 |
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13 |
In Vitro Approaches to Developmental Neurotoxicity Lucio G.
Costa, Gennaro
Giordano and Marina Guizzetti |
159 |
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14 |
Reproductive
and Developmental Toxicity Models in Relation to Neurodegenerative Diseases Marta Di
Carlo |
167 |
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15 |
Using Zebrafish to
Assess Developmental Neurotoxicity Stephanie Padilla and Robert MacPhail |
179 |
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16 |
Caenorhabditis Elegans as a Model to Assess Reproductive and Developmental Toxicity Daiana S, Avila, Margaret R. Adams, Sudipta Chakraborty and Michael Aschner |
193 |
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17 |
A Primate
as an Animal Model for Reproductive and Developmental Toxicity Testing Ah |
207 |
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18 |
Developmental
Immunotoxicity
Testing Susan L.
Makris and Scott Glaberman |
219 |
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19 |
In Vitro Biomarkers of Developmental Neurotoxicity Magdalini Sachana, John Flaskos and Alan J. Hargreaves |
227 |
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20 |
In Vivo Biomarkers and Biomonitoring in Reproductive and
Developmental Toxicity Dana Boyd Ban and Brian Buckley |
253 |
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SECTION 3 |
NANOPARTICLES AND RADIATION |
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21 |
Developmental
Toxicity of Engineered Nanoparticles Karin Sarig
Hougaard, Bengt Fadeel, Mary Gulumian,
Valerian E. Kagan and Kai M. Savolainen |
269 |
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22 |
Effects of
Radiation on the Reproductive System Kausik Ray and Rajani Choudhuri |
291 |
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SECTION 4 |
GASES AND SOLVENTS |
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23 |
Reproductive
and Developmental Toxicology: Toxic Solvents and Gases Suryanarayana V.
Vulimiri, M. Margaret Pratt, Shaila Kulkami, Sudheer Beedanagari and Brinda Mahadevan |
303 |
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SECTION 5 |
SMOKING, ALCOHOL, AND DRUGS OF ABUSE AND ADDICTION |
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24 |
Cigarette
Smoking and Reproductive and Developmental Toxicity Kathleen T. Shiverick |
319 |
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25 |
Effects of
Ethanol and Nicotine on Human CNS Development Noemi Robles and Fosefa
Sabriá |
333 |
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26 |
Developmental
Neurotoxicity
of Abused Drugs Jerrold S.
Meyer and Brian J. Piper |
341 |
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27 |
Caffeine Rosane Souza Da Silva |
355 |
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SECTION 6 |
FOOD ADDITIVES, NUTRACEUTICALS AND PHARMACEUTICALS |
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28 |
Melamine
and Cyanuric
Acid Karyn Bischoff |
367 |
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29 |
Ionophores Meliton N. Novilla |
373 |
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30 |
Selected
Herbal Supplements and Nutraceuticals Manashi Bagchi, Sangeeta Patel, Shirley Zafra-Stone and Debasis Bagchi |
385 |
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31 |
Thalidomide Neil Vargesson |
395 |
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SECTION 7 |
METALS |
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32 |
Aluminum José L. Domingo |
407 |
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33 |
Arsenic,
Cadmium and Lead Swaran J.S.
Flora, Vidhu
Pachauri
and Geetu Saxena |
415 |
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34 |
Manganese Dejan Milatovic, Ramesh C. Gupta, Zhaobao
Yin, Snjezana
Zaja-Milatovic
and Michael Aschner |
439 |
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35 |
Mercury Mingwei Ni, Xin Li, Ana Paula Marreilha Dos
Santos, Marcelo Farina, Joao Batista Teixeira Da Rocha, Daiana S. Avila, Offie
P. Soldin, Lu Rongzhu and Michael Aschner |
451 |
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36 |
Selenium T. Zane Davis and
Jeffery O. Hall |
461 |
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SECTION 8 |
PESTICIDES AND OTHER ENVIRONMENTAL CONTAMINANTS |
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37 |
Organophosphate
and Carbamate
Pesticides Ramesh C.
Gupta, Jitendra
K. Malik and Dejan
Milatovic |
471 |
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38 |
Chlorinated
Hydrocarbons and Pyrethrins/Pyrethroids Jitendra K.
Malik, Manoj Aggarwal,
Starling Kalpana
and Ramesh
C. Gupta |
487 |
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39 |
Herbicides
and Fungicides P.K.
Gupta |
503 |
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40 |
Brominated Flame Retardants Prasada Rao S. Kodavanti, David
T. Szabo, Tammy E. Stoker and Suzanne E. Fenton |
523 |
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41 |
Polychlorinated
Biphenyls, Polychlorinated Dibenzo-P-Dioxins
and Polychlorinated Dibenzofurans Steven J. Bursian, John L. News Ted and Mattherv J. Zwiernik |
543 |
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42 |
Developmental
Dioxin Exposure and Endometriosis Tultul Nayyar, Kaylon L. Bruner-Tran and Kevin G.
Osteen |
569 |
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43 |
Reproductive
Toxicity of Polycyctic
Aromatic Hydrocarbons: Occupational Relevance Aramandla Ramesh
and Anthony E, Archibong |
577 |
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44 |
Developmental
Toxicity of Polycyclic Aromatic Hydrocarbons Darryl B. Hood, Aramandla Ramesh, Sanika Chirwa, Habibeh Khoshbouei and Anthony E. Archibong |
593 |
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45 |
Ethylene
Glycol Edward W. Carney |
607 |
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46 |
Methyl Tert-Butyl Ether Dongmci Li and Xiaodong Han |
617 |
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47 |
Perfluorooctane Sulfonate (PFOS)
and Perfluorooctanoic
Acid (PFOA) Henrik Viberg and per Eriksson |
623 |
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48 |
Phthalates Jan L. Lyche |
637 |
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49 |
Organotins (Tributyltin and Triphenyltin) John
D. Doherty and William A. Irwin |
657 |
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50 |
Bisphenol A Patrick Allard and Monica P. Colaidcovo |
673 |
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SECTION 9 |
PHYTOTOXICANTS |
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51 |
Toxic
Plants Kip E. Panter, Kevin D.
Welch and Dale R. Gardner |
689 |
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52 |
Phytoestrogens Michelle
Mostrom
and TimothyJ. Evans |
707 |
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SECTION 10 |
BIOTOXINS |
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53 |
Fumonisins Kenneth
A. Voss, Ronald T. Riley and Janee Gelineau-van Waes |
725 |
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54 |
Trichothecenes and Zearalenone Michelle
Mostrom |
739 |
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55 |
Aflatoxins, Ochratoxins and Citrinin Ramesh C.
Gupta |
753 |
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56 |
Zootoxins Sharon M. Gwaltney-Brant |
765 |
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57 |
HIV-1 Tat
Toxins Shilpa Bitch and Hongkong Yao |
773 |
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SECTION 11 |
SPECIAL TOPICS |
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58 |
Applications
of Stem Cells in Developmental Toxicology Deborah K. Hansen and
Amy L. Inselman |
783 |
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59 |
Applications
of Toxicogenomics
in Reproductive and Developmental Toxicology Krishanu Sengupta, Jayaprakash Narayana Kolla, Debasis Bagchi and Manashi Bagchi |
793 |
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60 |
Epigenetic
Regulation of Gene and Genome Expression Supratim Choudhuri |
801 |
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61 |
Mitochondrial
Dysfunction in Reproductive and Developmental Toxicity Carlos M. Palmeira and Joăo Ramalho-Santos |
815 |
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62 |
Stress: Its
Impact on Reproductive and Developmental Toxicity Kavita Gulati
and Arunabha
Ray |
825 |
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63 |
Cell
Signaling Mechanisms in Developmental Neurotoxicity Chunjuan Song, Arthi
Kanthasamy
and Anumantha
G. Kanthasamy |
835 |
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64 |
Neuroinflammation and Oxidative
Injury in Developmental Neurotoxicity Dejan Milatovic, Snjezana Zaja-Milatovic, Rich M. Breyer, Michael Aschner and Thomas J. Montine |
847 |
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65 |
Disruption
of Cholesterol Homeostasis in Developmental Neurotoxicity Marina Guizzetti, Jing Chen and Lucio G. Costa |
855 |
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66 |
Cholinergic
Toxicity and the Male Reproductive System Inbal Mor and Hermona Soreq |
863 |
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SECTION 12 |
ENDOCRINE DISRUPTION MUTAGENICITY, CARCINOGENICITY,
INFERTILITY AND TERATOGENICITY |
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67 |
Endocrine
Disruptors Timothy J.
Evans |
873 |
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68 |
Screening
Systems for Endocrine Disruptors Teruo Sugawara |
893 |
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69 |
Developmental
and Reproductive Disorders: Role of Endocrine Disruptors in Testicular
Toxicity Bashir M.
Rezk and Suresh
C. Sikka |
903 |
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70 |
Mutagenicity and
Carcinogenicity: Human Reproductive Cancer and Risk Factors Hyung Sik Kim and Byung Mu Lee |
913 |
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71 |
Genotoxicities and Infertility Tirupapuliyur V.
Damodaran |
923 |
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72 |
Occupational
Exposure to Chemicals and Reproductive Health Helena Taskinen, Marja-Liisa Lindbohm and Markka Sallmén |
949 |
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73 |
Teratogenicity Vincent
F. Garry and Peter Truran |
961 |
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74 |
Ultrasound
and Magnetic Resonance in Prenatal Diagnosis of Congenital Anomalies Aleksandra Novakov
Mikic, Kaiarina Koprivsek and Dusco Kozic |
971 |
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75 |
Micro-CT
and Volumetric Imaging in Developmental Toxicology Xiaoycu Ying, Norman J. Barlow
and Maureen H. Feuston |
983 |
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SECTION 13 |
TOXICOLOGIC PATHOLOGY |
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76 |
Toxicologic Pathology of the
Reproductive System Pralhad Wangikar, Tausif Ahmed and Subrahmanyam Vangala |
1003 |
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SECTION 14 |
PLACENTAL TOXICITY |
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77 |
Strategies
for Investigating Hemochorial
Placentation Stephen J. Renaud and Michael J. Soarcs |
1029 |
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78 |
The
Placenta] Role in Fetal Programming Rohan M.
Lewis, Jane K. Deal and
Keith M. Godfrey |
1039 |
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79 |
The
Significance of ABC Transporters in Human Placenta for the Exposure of the
Fetus to Xenobiotics Kirsi H.
Vähäkangas, Jenni Veid, Vesa Karttunen, Heidi
Partanen, Elina Sieppi, Maria Kummu, Päivi Myllynen and Jarkko Loikkanen |
1051 |
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80 |
Placental
Toxicity Ramesh C. Gupta |
1067 |
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81 |
Placental
Pathology Drucilla J.
Roberts |
1087 |
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SECTION 15 |
DOMESTIC, WILDLIFE AND AQUATIC SPECIES |
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82 |
Reproductive
and Developmental Toxicity in Avian Species Robert W. Coppock and Margitta M. Dziwenka |
1109 |
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83 |
Endocrine
Disruption in Wildlife Species Robert W.
Coppock |
1117 |
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84 |
Teratogeneses in Livestock Robert W. Coppock
and Margitta
M. Dziwenka |
1127 |
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85 |
Mare
Reproductive Loss Syndrome Manu Sebastian |
1139 |
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86 |
Reproductive
and Developmental Toxicity in Fishes Helmut Segner |
1145 |
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Index |
1167 |
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