Table of Contents

 

 

 

1

Background and History

1

2

Basic Cell Biology: Structure and Function of Genes and Chromosomes

5

3

Genetic Variation: Its Origin and Detection

26

4

Autosomal Dominant and Recessive Inheritance

56

5

Sex-Linked and Nontraditional Modes of Inheritance

76

6

Clinical Cytogenetics: The Chromosomal Basis of Human Disease

100

7

Biochemical Genetics: Disorders of Metabolism

128

8

Gene Mapping and Identification

150

9

Immunogenetics

176

10

Developmental Genetics

193

11

Cancer Genetics

212

12

Multifactorial Inheritance and Common Diseases

231

13

Genetic Testing and Gene Therapy

258

14

Genetics and Personalized Medicine

284

15

Clinical Genetics and Genetic Counseling

292

 

Glossary

311

 

Answers to Study Questions

328

 

Index

339