Table of Contents

 

 

 

1

Introduction to Pathology

1

 

Disease

1

 

Inflammation

3

 

Edema

4

 

Ischemia and Infarction

5

 

Hemorrhage

5

 

Alterations of Cell Growth

6

 

Neoplasia

7

 

Hereditary Diseases

9

 

Disorders of Immunity

11

 

Infectious Disease Exposure

11

 

Acquired Immunodeficiency Syndrome

12

2

Specialized Imaging Techniques

15

 

Diagnostic Imaging Modalities

15

 

Mammography

16

 

Ultrasound

16

 

Computed Tomography

19

 

Magnetic Resonance Imaging

23

 

Nuclear Medicine

27

 

Single-Photon Emission Computed Tomography

28

 

Positron Emission Tomography

29

 

Fusion Imaging

31

3

Respiratory System

34

 

Physiology of the Respiratory System

36

 

Internal Devices

38

 

Endotracheal Tube

38

 

Central Venous Catheters

38

 

Swan-Ganz Catheter

39

 

Transvenous Cardiac Pacemakers

40

 

Congenital/Hereditary Diseases

41

 

Cystic Fibrosis

41

 

Hyaline Membrane Disease

42

 

Inflammatory Disorders of the Upper Respiratory System

43

 

Croup

43

 

Epiglottitis

43

 

Inflammatory Disorders of the Lower Respiratory System

44

 

Pneumonia

44

 

Anthrax

46

 

Lung Abscess

46

 

Tuberculosis

47

 

Pulmonary Mycosis

50

 

Respiratory Syncytial Virus

51

 

Severe Acute Respiratory Syndrome

52

 

Diffuse Lung Disease

53

 

Chronic Obstructive Pulmonary Disease

53

 

Sarcoidosis

56

 

Pneumoconiosis

58

 

Neoplasms

61

 

Solitary Pulmonary Nodule

61

 

Bronchial Adenoma

62

 

Bronchogenic Carcinoma

62

 

Treatment of Pulmonary Neoplastic Diseases

65

 

Pulmonary Metastases

65

 

Vascular Diseases

66

 

Pulmonary Embolism

66

 

Septic Embolism

71

 

Pulmonary Arteriovenous Fistula

71

 

Miscellaneous Lung Disorders

72

 

Atelectasis

72

 

Adult Respiratory Distress Syndrome

73

 

Intrabronchial Foreign Bodies

74

 

Mediastinal Emphysema (Pneumomediastinum)

74

 

Subcutaneous Emphysema

75

 

Treatment of Mediastinal and Subcutaneous Emphysema

75

 

Disorders of the Pleura

76

 

Pneumothorax

76

 

Pleural Effusion

77

 

Empyema

78

 

Mediastinal Masses

79

 

Disorders of the Diaphragm

80

 

Diaphragmatic Paralysis

81

 

Eventration of the Diaphragm

82

 

Other Causes of Elevation of the Diaphragm

83

4

Skeletal System

85

 

Physiology of the Skeletal System

87

 

Congenital/Hereditary Diseases of Bone

88

 

Vertebral Anomalies

88

 

Spina Bifida

89

 

Osteopetrosis

90

 

Osteogenesis Imperfecta

91

 

Achondroplasia

91

 

Congenital Hip Dysplasia (Dislocation)

92

 

Inflammatory and Infectious Disorders

93

 

Rheumatoid Arthritis

93

 

Rheumatoid Variants: Ankylosing Spondylitis, Reiter’s Syndrome, and Psoriatic Arthritis

94

 

Osteoarthritis (Degenerative Joint Disease)

97

 

Infectious Arthritis

98

 

Treatment of Arthritis

99

 

Bursitis

100

 

Rotator Cuff Tears

102

 

Tears of the Menisci of the Knee

102

 

Bacterial Osteomyelitis

103

 

Tuberculous Osteomyelitis

106

 

Metabolic Bone Disease

108

 

Osteoporosis

108

 

Osteomalacia

109

 

Rickets

109

 

Treatment for Osteomalacia and Rickets

111

 

Gout

111

 

Paget’s Disease

113

 

Lead Poisoning

114

 

Fibrous Dysplasia

116

 

Ischemic Necrosis of Bone

116

 

Benign Bone Tumors

118

 

Treatment of Benign Bone Tumors

122

 

Malignant Bone Tumors

123

 

Treatment of Malignant Bone Tumors

127

 

Bone Metastases

127

 

Fractures

131

 

Types of Fractures

131

 

Fracture Healing

134

 

Pathologic Fractures

136

 

Stress Fractures

136

 

Battered-Child Syndrome

137

 

Common Fractures and Dislocations

138

 

Fractures and Dislocations of the Spine

142

 

Herniation of Intervertebral Disks

146

 

Scoliosis

146

 

Spondylolysis and Spondylolisthesis

149

5

Gastrointestinal System

153

 

Physiology of the Digestive System

154

 

Esophagus

157

 

Tracheoesophageal Fistula

157

 

Esophagitis

159

 

Ingestion of Corrosive Agents

162

 

Esophageal Cancer

163

 

Esophageal Diverticula

164

 

Esophageal Varices

165

 

Hiatal Hernia

166

 

Achalasia

166

 

Foreign Bodies

167

 

Perforation of the Esophagus

168

 

Stomach

171

 

Gastritis

171

 

Pyloric Stenosis

171

 

Peptic Ulcer Disease

172

 

Cancer of the Stomach

175

 

Small Bowel

176

 

Crohn’s Disease (Regional Enteritis)

176

 

Small Bowel Obstruction

179

 

Adynamic Ileus

182

 

Intussusception

183

 

Malabsorption Disorders

184

 

Colon

185

 

Appendicitis

185

 

Diverticulosis

187

 

Diverticulitis

187

 

Ulcerative Colitis

188

 

Crohn’s Colitis

191

 

Ischemic Colitis

192

 

Irritable Bowel Syndrome

193

 

Cancer of the Colon

193

 

Large Bowel Obstruction

195

 

Volvulus of the Colon

195

 

Hemorrhoids

196

 

Gallbladder

199

 

Gallstones (Cholelithiasis)

199

 

Acute Cholecystitis

200

 

Emphysematous Cholecystitis

201

 

Treatment for Cholecystitis

201

 

Porcelain Gallbladder

202

 

Liver

202

 

Hepatitis

202

 

Cirrhosis of the Liver

204

 

Hepatocellular Carcinoma

205

 

Hepatic Metastases

207

 

Pancreas

208

 

Acute Pancreatitis

208

 

Chronic Pancreatitis

209

 

Treatment of Acute and Chronic Pancreatitis

210

 

Pancreatic Pseudocyst

210

 

Cancer of the Pancreas

211

 

Pneumoperitoneum

213

 

Spleen

215

 

Enlargement

215

 

Rupture

215

 

Treatment of Splenic Disorders

216

6

Urinary System

219

 

Physiology of the Urinary System

219

 

Congenital/Hereditary Diseases

222

 

Anomalies of Number and Size

222

 

I Anomalies of Rotation, Position, and Fusion

222

 

Anomalies of Renal Pelvis and Ureter

224

 

Treatment of Congenital/Hereditary Anomalies

225

 

Ureterocele

225

 

Posterior Urethral Valves

225

 

Inflammatory Disorders

225

 

Glotmerulonephritis

225

 

Pyelonephritis

227

 

Tuberculosis

229

 

Papillary Necrosis

230

 

Cystitis

230

 

Urinary Calculi

232

 

Urinary Tract Obstruction

236

 

Cysts and Tumors

238

 

Renal Cyst

238

 

Polycystic Kidney Disease

239

 

Renal Carcinoma

241

 

Wilms’ Tumor (Nephroblastoma)

244

 

Carcinoma of the Bladder

245

 

Renal Vein Thrombosis

246

 

Acute Renal Failure

248

 

Chronic Renal Failure

249

7

Cardiovascular System

251

 

Physiology of the Cardiovascular System

251

 

Congenital Heart Disease

255

 

Left-To-Right Shunts

255

 

Tetralogy of Fallot

256

 

Coarctation of the Aorta

257

 

Acquired Vascular Disease

259

 

Coronary Artery Disease

259

 

Congestive Heart Failure

263

 

Pulmonary Edema

264

 

Treatment of Congestive Heart Failure and Pulmonary Edema

265

 

Hypertension

266

 

Hypertensive Heart Disease

268

 

Aneurysm

269

 

Traumatic Rupture of the Aorta

270

 

Dissection of the Aorta

272

 

Atherosclerosis

273

 

Thrombosis and Embolism

275

 

Valvular Disease

278

 

Rheumatic Heart Disease

278

 

Mitral Stenosis

279

 

Mitral Insufficiency

280

 

Treatment of Mitral Stenosis and Mitral Insufficiency

281

 

Aortic Stenosis

281

 

Aortic Insufficiency

281

 

Treatment of Aortic Stenosis and Aortic Insufficiency

281

 

Infective Endocarditis

282

 

Pericardial Effusion

283

 

Venous Disease

285

 

Deep Venous Thrombosis

285

 

Varicose Veins

285

8

Nervous System

290

 

Physiology of the Nervous System

291

 

Infections of the Central Nervous System

294

 

Meningitis

294

 

Encephalitis

295

 

Brain Abscess

296

 

Subdural Empyema

297

 

Epidural Empyema

297

 

Treatment of Subdural and Epidural Empyemas

298

 

Osteomyelitis of the Skull

298

 

Tumors of the Central Nervous System

299

 

Glioma

300

 

Meningioma

303

 

Acoustic Neuroma

303

 

Pituitary Adenoma

304

 

Craniopharyngioma

308

 

Pineal Tumors

309

 

Chordoma

310

 

Metastatic Carcinoma

311

 

Traumatic Processes of the Brain and Skull

313

 

Skull Fracture

313

 

Epidural Hematoma

315

 

Subdural Hematoma

315

 

Cerebral Contusion

316

 

Intracerebral Hematoma

317

 

Subarachnoid Hemorrhage

317

 

Carotid Artery Injury

317

 

Facial Fractures

318

 

Vascular Disease of the Central Nervous System

321

 

Stroke Syndrome

322

 

Transient Ischemic Attacks

323

 

Intraparenchymal Hemorrhage

324

 

Subarachnoid Hemorrhage

327

 

Multiple Sclerosis

329

 

Epilepsy and Convulsive Disorders

331

 

Degenerative Diseases

332

 

Normal Aging

332

 

Alzheimer’s Disease

332

 

Huntington’s Disease

332

 

Parkinson’s Disease

334

 

Cerebellar Atrophy

334

 

Amyotrophic Lateral Sclerosis (Lou Gehrig’s Disease)

335

 

Hydrocephalus

335

 

Sinusitis

337

9

Hematopoietic System

341

 

Physiology of the Blood

341

 

Diseases of Red Blood Cells

342

 

Anemia

342

 

Polycythemia

347

 

Treatment of Polycythemias

347

 

Diseases of White Blood Cells

348

 

Leukemia

348

 

Lymphoma

349

 

Infectious Mononucleosis

354

 

Diseases of Platelets (Bleeding Disorders)

354

 

Hemophilia

355

 

Purpura (Thrombocytopenia)

356

10

Endocrine System

359

 

Physiology of the Endocrine System

359

 

Adrenal Glands

360

 

Physiology of the Adrenal Glands

360

 

Diseases of the Adrenal Cortex

360

 

Diseases of the Adrenal Medulla

364

 

Pituitary Gland

369

 

Physiology of the Pituitary Gland

369

 

Diseases of the Pituitary Gland

370

 

Thyroid Gland

373

 

Physiology of the Thyroid Gland

373

 

Diseases of the Thyroid Gland

373

 

Parathyroid Glands

379

 

Physiology of the Parathyroid Glands

379

 

Diseases of the Parathyroid Glands

379

 

Diabetes Mellitus

384

11

Reproductive System

389

 

Infectious Diseases of Both Genders

389

 

Syphilis

389

 

Gonorrhea

391

 

Male Reproductive System

392

 

Physiology of the Male Reproductive System

392

 

Benign Prostatic Hyperplasia

393

 

Carcinoma of the Prostate Gland

394

 

Staging

395

 

Undescended Testis (Cryptorchidism)

396

 

Testicular Torsion and Epididymitis

398

 

Testicular Tumors

399

 

Female Reproductive System

401

 

Physiology of the Female Reproductive System

401

 

Pelvic Inflammatory Disease

402

 

Cysts and Tumors

404

 

Ovarian Cysts and Tumors

404

 

Dermoid Cyst (Teratoma)

406

 

Uterine Fibroids

407

 

Endometrial Carcinoma

409

 

Endometriosis

410

 

Carcinoma of the Cervix

411

 

Breast Lesions

413

 

Breast Cancer

413

 

Benign Breast Disease

417

 

Imaging in Pregnancy

419

 

Ectopic Pregnancy

423

 

Trophoblastic Disease

423

 

Female Infertility

424

12

Miscellaneous Diseases

426

 

Nutritional Diseases

426

 

Vitamin Deficiencies

426

 

Hypervitaminosis

428

 

Protein-Calorie Malnutrition (Kwashiorkor)

429

 

Obesity

429

 

Systemic Lupus Erythematosus

430

 

Melanoma

431

 

Muscular Dystrophy

433

 

Hereditary Diseases

433

 

Chromosomal Aberrations

433

 

Genetic Amino Acid Disorders

435