About the Editors

xiii

List of Contributors

xv

Preface to the Fourth Edition

xxiii

Preface to the Fifth Edition

xxv

Foreword

xxvii

Introduction

Historical perspectives   Michael J. Denham and John E. Morley

1

PART 1

AGEING: BIOLOGICAL, SOCIAL AND COMMUNITY PERSPECTIVES

1

A biological perspective of ageing   H. James Armbrecht

13

2

The demography of ageing   Kenneth G. Manton and John E. Morley

23

3

The physiology of ageing   Rafi T. Kevorkian and John E. Morley

33

4

Psychological aspects of ageing   Peggy A. Szwabo

43

5

Ageing of the brain   Jean-François Démonet and Pierre Celsis

49

6

Epidemiology of ageing and disability   Lenise A. Cummings-Vaughn

55

7

Social and community aspects of ageing   John E. Morley and Nina Tumosa

67

8

The developmental origins of ageing   Avan Aihie Sayer and Cyrus Cooper

81

9

Sexuality and ageing   John E. Morley and Debbie T. Tolson

93

10

Physical fitness and exercise   Maria A. Fiatarone Singh and John E. Morley

103

11

Health literacy and cultural sensitivity   Nina Tumosa

121

PART 2

MEDICINE AND PRESCRIBING IN OLD AGE

12

Preventive geriatrics   Gerald M. Mahon, Joseph H. Flaherty and Suzanne M. Mahon

135

13

Polypharmacy   Oscar A. Cepeda and John E. Morley

145

14

Patient safety   Susannah Long and Charles Vincent

153

SECTION 1

EATING DISORDERS AND NUTRITIONAL HEALTH

15

Epidemiology of nutrition and ageing   Wija A. van Staveren and Lisette C.P.G.M. de Groot

173

16

The anorexia of ageing   Ian M. Chapman

185

17

Weight loss   David R. Thomas

197

18

Dehydration   David R. Thomas

209

19

Vitamins and minerals   Seema Joshi and John E. Morley

217

20

Obesity   Joan Khoo, Richard Y.T. Chen and Gary A. Wittert

237

SECTION 2

CASTRO DISORDERS

21

Changes in gastrointestinal motor and sensory function associated with ageing   Christopher K. Rayner and Michael Horowitz

249

22

Gastrointestinal bleeding   Syed H. Tariq

265

23

Liver and gall bladder   Margaret-Mary G. Wilson

275

24

Sphincter f unction   Syed H. Tariq

289

25

Constipation   Charlene M. Prather

303

26

Management of diarrhoea   Lenise A. Cummings-Vaughn

313

27

Diseases of the pancreas   John S. Morris and John E. Morley

321

SECTION 3

HAEMATOLOGICAL DISORDERS

28

Anaemia   Anjali S. Kamat and David R. Thomas

331

29

Disorders of haemostasis   Kingsley K. Hampton

343

30

Disseminated intravascular coagulation   Kingsley K. Hampton

353

31

Anticoagulants   Hamsaraj G.M. Shetty and Philip A, Routledge

357

32

Myelodysplasia   Martha Wadleigh, David S. Rosenthal and Richard M. Stone

363

33

Management of myelodysplastic syndromes and acute leukaemia   Heidi D. Klepin and Bayard L. Powell

375

SECTION 4

CARDIOVASCULAR DISEASES AND HEALTH

34

Epidemiology of heart disease   Ahmed H. Abdelhafiz

389

35

Cardiac ageing and. systemic disorders   David J. Stott and Terence J. Quinn

405

36

Arrhythmias   Abhay Bajpai and A. John Camm

413

37

Ischaemic heart disease   Wilbert S. Aronow

437

38

Lipid management   Adie Viljoen and Anthony S. Wierzbicki

449

39

Hypotension   Suraj Alakkassery

461

40

Hypertension   Anthony S. Wierzbicki and Adie Viljoen

471

41

Heart failure   Michael W. Rich

483

42

Cardiac surgery   Ulrich O. von Oppell and Adam Szafranek

499

43

Peripheral arterial disease   Leocadio Rodríguez Maňas, Marta Castro Rodríguez and Cristina Alonso Bouzón

517

44

Venous thromboembolism   Gordon D.O. Lowe

529

45

Cardiac rehabilitation   Niccolò Marchionni, Francesco Fattirolli, Francesco Orso, Marco Baccini, Lucio A. Rinaldi and Giulio Masotti

535

SECTION 5

RESPIRATORY DISEASES

46

Epidemiology of respiratory infection   Joseph M. Mylotte

551

47

Pneumonia   Joël Belmin

555

48

Aspiration pneumonia   Takashi Ohrui and Hiroyuki Arai

565

49

Interstitial lung disease and lung cancer   Christopher Dyer

573

50

Chronic obstructive pulmonary disease and asthma   Christopher Dyer

579

51

Pulmonary hypertension   Dennis J. Shale

589

52

Pulmonary rehabilitation   Peter Spiegler and Jonathan Ilowite

601

SECTION 6

CNS DISORDERS

53

Neurological signs of ageing   Andrew J. Lamer

609

54

Sleep apnoea and sleep disorders   Paul Montgomery and Lindsay Dianne Shepard

617

55

Headache   Stephen D. Silberstein and William B. Young

629

56

Normal pressure hydrocephalus   Dennis S. Oh and Peler McL. Black

643

57

Acute stroke care and management of carotid artery stenosis   David Doig and Martin M. Brown

655

58

Stroke and stroke rehabilitation   Lalit Kalra

675

59

Communication disorders and dysphagia   Pamela M. Enderby

691

60

Acute and chronic subdural haematoma   Eric Schmidt and Emmanuel Moyse

701

61

Epilepsy   Pamela M. Crawford

711

62

Syncope and non-epileptic attacks   Richard C. Roberts

721

63

Parkinson’s disease   Joël Belmin

731

64

Non-parkinsonian movement disorders   Katie Kompoliti and Cynthia L. Cornelia

739

65

Diabetic neuropathy   Aaron I. Vinik and Elsa S. Strotmeyer

751

66

Disorders of the neuromuscuiar junction   Sivakumar Sathasivam and Andrew J. Lamer

769

67

Muscle disorders   David Hilton-Jones

779

68

Motor neurone disease   Hardev S. Pall

793

69

Control of chronic pain   Robert D. Helme and Benny Katz

809

70

Multiple sclerosis   Florian P. Thomas

823

Appendix

Function assessment scales   John E. Morley

i

Index

xi