Preface

vii

Acknowledgments

ix

Introduction

xi

1

Studying a Study: M.A.A.R.I.E. Framework—Method, Assignment, Assessment

2

2

Studying a Study: M.A.A.R.I.E. Framework—Results

29

3

Studying a Study: M.A.A.R.I.E Framework—Interpretation, Extrapolation

54

4

Randomized Controlled Trials

74

5

Observational Studies

97

6

Safety

119

7

Meta-analysis

138

8

Testing a Test: M.A.A.R.I.E. Framework—Method, Assignment, and Assessment

159

9

Testing a Test: M.A.A.R.I.E. Framework—Results, Interpretation, Extrapolation

180

10

Screening—Prediction and Decision Rules

203

11

Decision and Cost-Effectiveness Analysis: M.A.A.R.I.E. Framework—Method, Assignment, Assessment

227

12

Decision and Cost-Effectiveness Analysis: M.A.A.R.I.E. Framework—Results, Interpretation, Extrapolation

250

13

A Guide to the Guidelines

270

14

Translating Evidence into Practice

295

Glossary

311

Index

327