Table of Contents

 

 

 

 

Preface

xiv

 

Acknowledgments

xv

Chapter 1

History of Echocardiography   Harvey Feigenbaum, MD

1

 

Development of Various Echocardiographic Technologies

2

 

Recording Echocardiograms

5

 

Cardiac Sonographers

5

 

Echocardiographic Education and Organizations

6

 

References

7

Chapter 2

Physics and Instrumentation

9

 

Physical Principles

9

 

Interaction Between Ultrasound and Tissue

10

 

The Transducer

12

 

Manipulating the Ultrasound Beam

14

 

Resolution

16

 

Creating the Image

17

 

Transmitting Ultrasound Energy

19

 

Display Options

20

 

Tradeoffs in Image Creation

22

 

Signal Processing

22

 

Tissue Harmonic Imaging

23

 

Artifacts

25

 

Doppler Echocardiography

26

 

Principles of Doppler Ultrasound

26

 

Doppler Formats

29

 

Color Flow Imaging

32

 

Technical Limitations of Color Doppler Imaging

33

 

Doppler Artifacts

34

 

Tissue Doppler Imaging

35

 

Biologic Effects of Ultrasound

35

 

Suggested Readings

37

Chapter 3

Specialized Echocardiographic Techniques and Methods

39

 

Imaging Devices and Methods

39

 

M-Mode Echocardiography

39

 

Two-Dimensional Echocardiography

40

 

Color B-Mode Scanning

40

 

Doppler Interrogation

40

 

Color Flow Doppler Imaging

43

 

Color Doppler M-Mode Imaging

43

 

Doppler Tissue Imaging

45

 

Speckle Tracking

48

 

Tissue Characterization

50

 

Acquisition of Cardiac Ultrasound Information

51

 

Transthoracic Echocardiography

51

 

Hand-Carried Ultrasound

52

 

Dedicated Single-Line Interrogation Transducers

52

 

Transesophageal Echocardiography

53

 

Three-Dimensional Echocardiography

55

 

Epicardial Imaging

61

 

Intracardiac Echocardiography

62

 

Intravascular Ultrasound

63

 

The Digital Echo Laboratory

63

 

Suggested Readings

66

Chapter 4

Contrast Echocardiography

67

 

Source of Ultrasound Contrast

67

 

Contrast Agents

67

 

Safety

69

 

Clinical Use

69

 

Ultrasound Interaction with Contrast Agents

70

 

Detection Methods

71

 

Machine Settings

71

 

Intermittent Imaging

72

 

Low Mechanical Index Imaging

72

 

Other Mechanical Factors Affecting Contrast Detection

72

 

Doppler Imaging

73

 

Contrast Artifacts

73

 

Detection and Utilization of Intracavitary Contrast

76

 

Intramural Cavity Flow, Trabecilation, Incomplete Filling

77

 

Enhancement of Doppler Signals

78

 

Shunt Detection

81

 

Detection of Miscellaneous Conditions

84

 

Myocardial Perfusion Contrast Echocardiography

85

 

Suggested Readings

89

Chapter 5

The Echocarbiographic Examination

91

 

Selecting the Transducers

93

 

Patient Position

93

 

Placement of the Transducer

95

 

An Approach to the Transthoracic Examination

96

 

Parasternal Long-Axis Views

96

 

Parasternal Short-Axis Views

97

 

Apical Views

102

 

The Subcostal Examination

106

 

Suprasternal Views

107

 

Orientation of Two-Dimensional Images

108

 

Echocardiographic Measurements

111

 

Left Ventricular Wall Segments

112

 

M-Mode Examination

113

 

Transesophageal Echocardiography

114

 

Transesophageal Echocardiographic Views

115

 

Echocardiography as a Screening Test

120

 

Training in Echocardiography

120

 

Suggested Readings

120

Chapter 6

Evaluation of Systolic Function of the Left Ventricle

123

 

General Principles

123

 

Linear Measurements

123

 

Indirect M-Mode Markers of Left Ventricular Function

125

 

Two-Dimensional Measurements

126

 

Assessment of Left Ventricular Function with Three-Dimensional Echocardiography

128

 

Determination of Left Ventricular Mass

131

 

Physiologic versus Pathologic Hypertrophy

132

 

Regional Left Ventricular Function

133

 

Quantitative Techniques

133

 

Nonischemic Wall Motion Abnormalities

135

 

Premature Ventricular Contractions

139

 

Paced Rhythms

139

 

Ventricular Preexcitation

139

 

Postoperative Cardiac Motion

140

 

Posterior Compression

141

 

Pericardial Constriction

142

 

Doppler Evaluation of Global Left Ventricular Function

142

 

Myocardial Performance Index

143

 

Other Techniques for Determination of Left Ventricular Systolic Function

144

 

Determination of Left Ventricular Dp/Dt

145

 

Newer and Advanced Methods for Evaluating Left Ventricular Function

146

 

Strain and Strain Rate Imaging

148

 

Ventricular Torsion

155

 

Conclusion

155

 

Suggested Readings

156

Chapter 7

Evaluation of Left Ventricular Diastolic Function

159

 

Normal Diastolic Function

159

 

Stages of Diastolic Dysfunction

160

 

Normal Diastolic Function

160

 

Impaired Relaxation, Grade I

161

 

Pseudonormalization, Grade II

162

 

Restrictive Filling (Reversible), Grade III

162

 

Restrictive Filling (Irreversible), Grade IV

163

 

Echo-Doppler Parameters of Diastolic Function

163

 

Isovolumic Relaxation Time

163

 

Mitral Inflow

164

 

Color M-Mode Flow Propagation Velocity (Vp)

165

 

Tissue Doppler Mitral Annular Velocity

166

 

Pulmonary Venous Flow Patterns

167

 

Left Atrial Volume

169

 

The Valsalva Maneuver

171

 

Other Markers of Diastolic Dysfunction

171

 

A Comprehensive Approach to Diastolic Dysfunction

172

 

Estimating Left Ventricular Filling Pressures

175

 

Stress Testing to Assess Diastolic Function

175

 

The Differential Diagnosis of Heart Failure with Normal Ejection Fraction

180

 

Evaluation of Diastolic Dysfunction in Specific Patient Groups

180

 

Sinus Tachycardia

180

 

Atrial Fibrillation

181

 

Mitral Valve Disease

181

 

Hypertrophic Cardiomyopathy

181

 

Prognosis in Patients with Diastolic Dysfunction

181

 

Suggested Readings

182

Chapter 8

Left and Right Atrium, and Right Ventricle

185

 

Left Atrium

185

 

Left Atrial Dimensions and Volume

185

 

Left Atrial Function

188

 

Atrial Septum

190

 

Pulmonary Veins

193

 

Right Atrium

196

 

Right Atrial Thrombi

199

 

Right Atrial Blood Flow

200

 

Right Ventricle

203

 

Right Ventricular Dimensions and Volumes

204

 

Right Ventricular Overload

209

 

Right Ventricular Dysplasia

213

 

Suggested Readings

214

Chapter 9

Hemodynamics

217

 

Use of M-Mode and Two-Dimensional Echocardiography

217

 

Quantifying Blood Flow

218

 

Clinical Application of Blood Flow Measurement

221

 

Measuring Pressure Gradients

223

 

Applications of the Bernoulli Equation

228

 

Determining Pressure Half-Time

233

 

The Continuity Equation

236

 

Proximal Isovelocity Surface Area

237

 

Myocardial Performance Index

239

 

Suggested Readings

240

Chapter 10

Pericardial Diseases

241

 

Clinical Overview

241

 

Echocardiographic Evaluation of the Pericardium

241

 

Detection and Quantitation of Pericardial Fluid

242

 

Direct Visualization of the Pericardium

246

 

Differentiation of Pericardial from Pleural Effusion

248

 

Cardiac Tamponade

248

 

Echocardiographic Findings in Cardiac Tamponade

249

 

Doppler Findings in Tamponade

251

 

Pericardial Constriction

254

 

Echocardiographic Diagnosis

254

 

Doppler Echocardiographic Findings in Constriction

256

 

Effusive Constrictive Pericarditis

257

 

Constrictive Pericarditis versus Restrictive Cardiomyapathy

258

 

Miscellaneous Pericardial Disorders and Observations

259

 

Postoperative Effusions

259

 

Echocardiography-Guided Pericardiocentesis

260

 

Congenital Absence of the Pericardium

261

 

Pericardial Cysts

261

 

Suggested Readings

262

Chapter 11

Aortic Valve Disease

263

 

Aortic Stenosis

263

 

Doppler Assessment of Aortic Stenosis

266

 

Other Approaches to Quantifying Stenosis

275

 

Defining the Severity of Aortic Stenosis

275

 

Dobutamine Echocardiography in the Evaluation of Aortic Stenosis

276

 

Natural History of Aortic Stenosis

276

 

Clinical Decision Making

278

 

Aortic Regurgitation

280

 

Appropriateness Criteria

280

 

M-Mode and Two-Dimensional Imaging

280

 

Establishing a Diagnosis of Aortic Regurgitation

283

 

Evaluating the Severity of Aortic Regurgitation

286

 

Acute versus Chronic Aortic Regurgitation

291

 

Assessing the Left Ventricle

291

 

Miscellaneous Abnormalities of the Aortic Valve

293

 

Suggested Readings

293

Chapter 12

Mitral Valve Disease

295

 

Anatomy of the Mitral Valve

295

 

Physiology of Mitral Valve Disease

297

 

Mitral Stenosis

297

 

Two-Dimensional Echocardiography in Rheumatic Mitral Stenosis

298

 

Congenital Mitral Stenosis

301

 

M-Mode Echocardiography

301

 

Transesophageal Echocardiography

302

 

Role of Three-Dimensional Echocardiography

303

 

Anatomic Determination of Severity

303

 

Doppler Echocardiographic Determination of Severity

304

 

Exercise Gradients

307

 

Secondary Features of Mitral Stenosis

307

 

Atrial Fibrillation

309

 

Secondary Pulmonary Hypertension

310

 

Decision Making Regarding Intervention

310

 

Mitral Regurgitation

310

 

Doppler Evaluation Ot Mitral Regurgitation

311

 

Flail Leaflets

313

 

Functional Mitral Regurgitation

318

 

Determination of Mitral Regurgitation Severity

320

 

Other Considerations in Assessing Mitral Regurgitation

324

 

Mitral Valve Prolapse

326

 

Miscellaneous Mitral Valve Abnormalities

330

 

Calcification of the Mitral Annulus

331

 

Tumors of the Mitral Valve

331

 

Aneurysms of the Mitral Valve

332

 

Endocarditis and Valve Perforation

334

 

Anular Dehiscence

334

 

Radiation Damage

334

 

Carcinoid and Diet Drug Valvulopathy

334

 

Suggested Readings

335

Chapter 13

Tricuspid and Pulmonary Valves

337

 

Clinical Overview

337

 

Pulmonary Valve

337

 

Pulmonary Valve Stenosis

341

 

Pulmonary Valve Regurgitation

342

 

Miscellaneous Abnormalities of the Pulmonary Valve

343

 

Evaluation of the Right Ventricular Outflow Tract

344

 

Tricuspid Valve

345

 

Doppler Evaluation of the Tricuspid Valve

346

 

Tricuspid Stenosis

348

 

Tricuspid Regurgitation

348

 

Pacemaker and Catheter-Induced Tricuspid Regurgitation

349

 

Ischemic Heart Disease

350

 

Quantitation of Tricuspid Regurgitation

351

 

Determination of Right Ventricular Systolic Pressure

353

 

Other Specific Conditions Resulting in Tricuspid and Pulmonary Valve Disease

355

 

Carcinoid Heart Disease

355

 

Endocardial Fibroelastosis

357

 

Ebstein Anomaly

357

 

Tricuspid Valve Resection

357

 

Cardiac Biopsy

359

 

Tumors and Other Masses

359

 

Suggested Readings

359

Chapter 14

Infective Endocarditis

361

 

Clinical Perspective

361

 

Echocardiographic Characteristics of Vegetation

361

 

Diagnostic Accuracy of Echocardiography

366

 

Evolution of the Diagnostic Criteria

367

 

Complications of Endocarditis

368

 

Prognosis and Predicting Risk

374

 

Prosthetic Valve Endocarditis

375

 

Infected Intracardiac Devices

377

 

Right-Sided Endocarditis

378

 

Approach to the Patient with Endocarditis

379

 

Suggested Readings

383

Chapter 15

Prosthetic Valves

385

 

Types of Prosthetic Valves

385

 

Normal Prosthetic Valve Function

386

 

Application of Echocardiography to Patients with Prosthetic Valves

392

 

General Approach to Prosthetic Valves

394

 

Prosthetic Aortic Valves

397

 

Prosthetic Mitral Valves

402

 

Specific Causes of Dysfunction

402

 

Obstruction

402

 

Infective Endocarditis

409

 

Mechanical Failure

415

 

Right-Sided Prosthetic Valves

415

 

Valved Conduits

419

 

Mitral Valve Repair

419

 

Suggested Readings

424

Chapter 16

Echocardiography and Coronary Artery Disease

427

 

Clinical Overview

427

 

Pathophysiology of Coronary Syndromes

427

 

Detection and Quantitation of Wall Motion Abnormalities

431

 

Role of the Three-Dimensional Echocardiography

436

 

Doppler Tissue Imaging and Speckle Tracking

437

 

Other Methods for Evaluating Ischemic Myocardium

438

 

Echocardiographic Evaluation of Clinical Syndromes

438

 

Angina Pectoris

438

 

Acute Myocardial Infarction

438

 

Natural History of Wall Motion Abnormalities

444

 

Prognostic Implications

446

 

Doppler Evaluation of Systolic and Diastolic Function in Acute Myocardial Infarction

446

 

Complications of Acute Myocardial Infarction

448

 

Pericardia! Effusion

448

 

Infarct Expansion/Acute Remodeling

450

 

Free-Wall Rupture

450

 

Ventricular Thrombus

451

 

Right Ventricular Infarction

451

 

Acute Mitral Regurgitation

453

 

Ventricular Septal Rupture

455

 

Cardiogenic Shock

457

 

Chronic Coronary Artery Disease

457

 

Left Ventricular Aneurysm

457

 

Left Ventricular Pseudoaneurysm

460

 

Chronic Remodeling

462

 

Mural Thrombus

462

 

Mitral Regurgitation

464

 

Chronic Ischemic Dysfunction

465

 

Direct Coronary Visualization

468

 

Kawasaki Disease

470

 

Direct Visualization of Atherosclerosis

470

 

Suggested Readings

471

Chapter 17

Stress Echocardiography

473

 

Physiologic Basis

473

 

Methodology

475

 

Treadmill

475

 

Bicycle Ergometry

476

 

Dobutamine Stress Echocardiography

477

 

Dipyridamole and Adenosine

478

 

Three-Dimensional Stress Echocardiography

478

 

Choosing Among the Different Stress Modalities

479

 

Interpretation of Stress Echocardiography

479

 

Categorization of Wall Motion

482

 

Wall Motion Response to Stress

484

 

Localization of Coronary Artery Lesions

484

 

Correlation with Symptoms and Electrocardiographic Changes

485

 

Detection of Coronary Artery Disease

486

 

Role of Myocardial Perfusion Imaging

488

 

Comparison with Nuclear Techniques

491

 

Applications of Stress Echocardiography

492

 

Prognostic Value of Stress Echocardiography

492

 

Stress Echocardiography After Myocardial Infarction

495

 

Stress Echocardiography After Revascularization

496

 

Preoperative Risk Assessment

498

 

Stress Echocardiography in Women

499

 

Assessment of Myocardial Viability

501

 

Stress Echocardiography in Valvular Heart Disease

502

 

Diastolic Stress Echocardiography

503

 

Suggested Readings

505

Chapter 18

Dilated Cardiomyopathies

507

 

Clinical and Echocardiographic Overview

507

 

Dilated Cardiomyopathy

507

 

Doppler Evaluation of Systolic and Diastolic Function

512

 

Assessment of Diastolic Functions

514

 

Myocardial Performance Index

516

 

Secondary Findings in Dilated Cardiomyopathy

517

 

Etiology of Dilated Cardiomyopathy

518

 

Determination of Prognosis in Dilated Cardiomyopathy

521

 

The Role of Echocardiography in Basic and Advanced Therapy

523

 

Biventricular Pacing for Congestive Heart Failure

523

 

Cardiac Transplantation and Other Advanced Support

527

 

Ventricular Assist Devices

530

 

Myocarditis

534

 

Peripartum Cardiomyopathy

536

 

Chagas Myocarditis

536

 

Suggested Readings

537

Chapter 19

Hypertrophic and Other Cardiomyopathies

539

 

Overview

539

 

Hypertrophic Cardiomyopathy

539

 

Echocardiographic Evaluation of Hypertrophic Cardiomyopathy

539

 

Assessment of the Left Ventricular Outflow Tract in Obstructive Cardiomyopathy

541

 

Mitral Regurgitation in Hypertrophic Cardiomyopathy

546

 

Variants of Hypertrophic Cardiomyopathy

547

 

Mid-Cavitary Obstruction

548

 

Screening of Family Members

549

 

Conditions Mimicking Hypertrophic Cardiomyopathy

550

 

End-Stage Hypertrophic Cardiomyopathy

553

 

Hypertrophic Cardiomyopathy Therapy

554

 

Infiltrative and Restrictive Cardiomyopathy

554

 

Echocardiographic Evaluation of Restrictive Cardiomyopathy

555

 

Cardiac Amyloid

556

 

Restrictive Cardiomyopathy

556

 

Constrictive versus Restrictive Heart Disease

556

 

Endocardial Fibroelastosis and Hypereosinophilic Syndrome

559

 

Suggested Readings

560

Chapter 20

Congenital Heart Diseases

561

 

The Echocardiographic Examination: a Segmental Approach to Anatomy

562

 

Cardiac Situs

562

 

Ventricular Morphology

563

 

Great Artery Connections

564

 

Abnormalities of Right Ventricular Inflow

565

 

Abnormalities of Left Ventricular Inflow

566

 

Pulmonary Veins

566

 

Left Atrium

567

 

Mitral Valve

570

 

Abnormalities of Right Ventricular Outflow

571

 

Right Ventricle

571

 

Pulmonary Valve

573

 

Pulmonary Artery

573

 

Abnormalities of Left Ventricular Outflow

575

 

Subvalvular Obstruction

576

 

Valvular Aortic Stenosis

578

 

Supravalvular Aortic Stenosis

580

 

Coarctation of the Aorta

581

 

Abnormalities of Cardiac Septation

584

 

Atrial Septal Defect

584

 

Ventricular Septal Defect

590

 

Endocardial Cushion Defect

600

 

Abnormal Vascular Connections and Structures

600

 

Patent Ductus Arteriosus

600

 

Abnormal Systemic Venous Connections

602

 

Abnormal Pulmonary Venous Connections

603

 

Abnormalities of the Coronary Circulation

608

 

Conotruncal Abnormalities

612

 

Tetralogy of Fallot

612

 

Transposition of the Great Arteries

615

 

Double-Outlet Right Ventricle

621

 

Persistent Truncus Arteriosus and Aortopulmonary Window

623

 

Abnormalities of Ventricular Development

623

 

Single Ventricle

624

 

Tricuspid Atresia

626

 

Echocardiographic Evaluation during and After Surgery

628

 

Systemic Arterv to Pulmonary Artery Shunts

628

 

The Fontan Procedure

629

 

Right Ventricle to Pulmonary Artery Conduits

630

 

Suggested Readings

632

Chapter 21

Diseases of the Aorta

633

 

Normal Aortic Anatomy

633

 

Echocardiographic Evaluation

634

 

Aortic Dilation and Aneurysm

637

 

Marfan Syndrome

640

 

Sinus of Valsalva Aneurysm

643

 

Aortic Dissection

645

 

Echocardiographic Diagnosis

646

 

Intramural Hematoma

653

 

Complications and Natural History of Aortic Dissection

655

 

Aortic Atheroma

657

 

Miscellaneous Conditions

661

 

Coarctation of the Aorta

661

 

Aortic Pseudoaneurysm

661

 

Aortic Trauma

661

 

Infections of the Aorta

662

 

Aortic Thrombus

663

 

Takayasu Arteritis

664

 

Suggested Readings

665

Chapter 22

ICU and Operative/Perioperative Applications

667

 

Evaluation of Patients in the Medical Intensive Care Unit

667

 

Hypotension and Shock

667

 

Evaluation of Hypoxia

671

 

Echocardiography in the Emergency Department

671

 

Echocardiography Following Cardiac Arrest

673

 

Pre-, Intra-, and Postoperative Echocardiography

673

 

Role of Echocardiography in Mitral Valve Surgery

676

 

Tricuspid Valve Repair

687

 

Role of Echocardiography in Aortic Valve Procedures

687

 

Miscellaneous Applications

692

 

Other Intraoperative Complications of Cardiac Surgery

693

 

Intraoperative Monitoring for Noncardiac Procedures

696

 

Delayed Cardiac Surgery Complications

696

 

Monitoring of Nonoperative and Interventional Procedures

698

 

Interventional Cardiac Procedures

700

 

Other Applications in the Catheterization Laboratory

708

 

Suggested Readings

708

Chapter 23

Masses, Tumors, and Source of Embolus

711

 

Normal Variants and Artifacts: Sources of False-Positive Findings

711

 

Role of Echocardiography

712

 

Cardiac Tumors

712

 

Primary Tumors

712

 

Metastatic Tumors to the Heart

717

 

Intracardiac Thrombi

720

 

Left Ventricular Thrombi

720

 

Left Atrial Thrombi

726

 

Right Atrial Thrombi

731

 

Spontaneous Echo Contrast

731

 

Role of Echocardiography in Systemic Embolus

732

 

Pseudotumors and Other Cardiac Masses

736

 

Suggested Readings

739

Chapter 24

Echocardiography in Systemic Disease and Clinical Problem Solving

741

 

Echocardiography and Systemic Disease

741

 

Hypertension

741

 

Diabetes Mellitus

743

 

Thyroid Disease

743

 

Chronic Renal Insufficiency

744

 

Connective Tissue/Autoimmune Disease

746

 

Systemic Lupus Erythematosus

746

 

Antiphospholipid Antibody Syndrome

747

 

Scleroderma/Raynaud Phenomenon

747

 

Marfan Syndrome

748

 

Chronic Liver Disease and Cirrhosis

750

 

Chronic Obstructive Pulmonary Disease

752

 

Pulmonary Hypertension

753

 

Miscellaneous Diseases

757

 

Sarcoidosis

757

 

Hemochromatosis

758

 

Muscular Dystrophy/Glycogen Storage Disease

758

 

Hypereosinophilia

758

 

Carcinoid Syndrome

759

 

Sickle Cell Anemia

759

 

Human Immunodeficiency Virus

759

 

Diet-Drug Valvulopathy

760

 

Obesity

760

 

Clinical Presentations and Problem Solving

760

 

Congestive Heart Failure

760

 

Evaluation of Dyspnea

761

 

Acute Pulmonary Embolus

762

 

Echocardiographic Findings

762

 

Atrial Fibrillation

763

 

Neurogenic Myocardial Stunning

766

 

Syncope

767

 

Evaluation of Cardiac Arrhythmias

767

 

Evaluation of Patients Before and during Chemotherapy

768

 

Radiation-Induced Cardiac Disease

768

 

Screening for Athletic Competition and the Athlete’s Heart

769

 

The Heart in Pregnancy

770

 

Effects of Advanced Age

772

 

Suggested Readings

773

 

Index

775