Table of Contents

 

 

 

 

Preface

vii

PART 1

INTRODUCTION TO CLINICAL HEMATOLOGY

1

Chapter 1

Morphology of Human Blood and Marrow Cells: Hematopoiesis   Ann Bell, MS, SH(ASCP), CLSpH(NCA), Denise M. Harmening. PhD, MT(ASCP), CLS(NCA), Virginia C Hughes, MS, MT(ASCP)SBB, CLS(NCA)I

1

Chapter 2

Bone Marrow   Aamir Ehsan, MD Jennifer L. Herrick, MD

42

Chapter 3

The Red Blood Cell: Structure and Function   Denise M. Harmening, PhD. MT(ASCP), CLS(NCA)

64

Chapter 4

Anemia: Diagnosis and Clinical Considerations   Armand B. Classman, MD

82

Chapter 5

Evaluation of Cell Morphology and Introduction to Platelet and White Blood Cell Morphology   Kathy W. Jones, MS, MT(ASCP), CLS(NCA)

93

PART 2

ANEMIAS

117

Chapter 6

Iron Metabolism and Hypochromic Anemias   Kathleen Finnegan, MS, MT(ASCP)SH

117

Chapter 7

Megaloblastic Anemias   Mirra Taghizdeh, MS, MT(ASCP), CLS(NCA)

138

Chapter 8

Aplastic Anemia Including Pure Red Cell Aplasia, Congenital Dyserythropoietic Anemia, and Paroxysmal Nocturnal Ilemoglobinuria   Sheme L. Perkins, MD, PhD

156

Chapter 9

Introduction to Hemolytic Anemias: Intracorpuscular Defects:

176

I

Hereditary Defects of the Red Cell Membrane   Thérèsa L, Coelzer, PhD, Stair Zail, MBBCh, MD, FRCtath

 

Chapter 10

Hemolytic Anemias: Intracorpuscular Defects:

196

II

Hereditary Enzyme Deficiencies   Armand B. Glassman, MD, Denise M. Harmening, PhD, MT(ASCP), CLS(NCA)

196

Chapter 11

Hemolytic Anemias: Intracorpuscular Defects:

207

III

The Hemoglobinopathies   Denise M. Marmening, PhD, MT(ASCP), CLS(NCA), David Yang, MD, Hallye Zeringer, MT(ASCP)SH

207

Chapter 12

Hemolytic Anemias: Intracorpuscular Defects:

230

IV

Thalassemia   Russell Aaron Higgins, MD Chantal Ricaud Harrison, MD

230

Chapter 13

Hemolytic Anemias: Extracorpuscular Defects   Denise M. Harmening, PhD, MT(ASCP), CLS(NCA), Louann W. Lawrence, DrPH, MT(ASCP)SH, CLSpH(NCA) Ralph Green, BAppSci(MLS), Faimls Carl R. Schaub. MD

252

Chapter 14

Hypoproliferative Anemia: Anemia Associated with Systemic Diseases   Carmen J. Julius, MD Carl R. Schaub, MD

280

PART 3

WHITE BLOOD CELL DISORDERS

305

Chapter 15

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis   Denise M. Harmening, PhD, MT(ASCP), CIS(NCA) Joe Marty, MS, MT(ASCP) Ronald G. Strauss, MD

305

Chapter 16

Introduction to Leukemia and the Acute Leukemias   Ken Gaiter, MD, JD, Frank Cruz III, MD Rita Bruziel, MD

331

Chapter 17

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia   Carl R. Schaub, MD

371

Chapter 18

Chronic Myeloproliferative Disorders II: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis   Kaihrina Chua, MD Meyer R. Heyman, MD

385

Chapter 19

Myelodysplastic Syndromes   Giovanni D’Angelo, FCMLS Luigina Mollica, MD, FRCP(C), PhD Josée Hébert, MD, FRCP(C) Lambert Basque, MD, FRCP(C)

412

Chapter 20

Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders   Laurel D, Holmer, MEd, MT(ASCP)SH, Carlos E. Bueso-Ramos, MD, PhD

440

Chapter 21

The Lymphomas   Dan M. Ryder, MD

466

Chapter 22

Multiple Myeloma and Related Plasma Cell Disorders   Ashraf Z. Badros, MD

500

Chapter 23

Lipid (Lysosomal) Storage Diseases and Histiocytosis   Denise M. Hamening, PhD, MT(ASCP), CLS(NCA) Catherine M. Spier, MD

525

PART 4

HEMOSTAS1S AND INTRODUCTION TO THROMBOSIS

543

Chapter 24

Introduction to Hemostasis   Denisp M. Harmening, PhD, MT(ASCP), CLS(NCA), Claudia E. Escobar, MT(ASCP)SH, David L, McClasson, MS, CLS(NCA)

543

Chapter 25

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders   Darla K. Liles, MD Charles L Knupp, MD

577

Chapter 26

Disorders of Plasma Clotting factors   Sharon L Schwartz, MS, MT(ASCP)SH, CLS(NCA)

607

Chapter 27

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology   John Lazarchick, MD, Melanie Oswald. MHS, MT(ASCP)SH

643

Chapter 28

Introduction to Thrombosis and Anticoagulant Therapy   Aamir Ehsan, MD Jennifer L. Herrick, MD

660

PART 5

LABORATORY METHODS

697

Chapter 29

Quality Management, Quality Assurance, and Quality Control   Kim A. Przekop. BS, MT(ASCP)

697

Chapter 30

Body Fluid Examination: The Qualitative Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids   Sharon L. Schwartz, MS, MT(ASCP)SH, CLS(NCA)

720

Chapter 31

Hematology Methods   Virginia C. Hughes, MS, MT(ASCP)SBB, CLS(NCA)I

759

Chapter 32

Principles of Automated Differential Analysis   Denise M. Harmening, PhD, MT(ASCP), CLS(NCA), Angelica Black, USAF, BSc, MS, MT(ASCP), Naomi B. Culp. DA, MT(ASCP)SH, Jolanta Kunicka, PhD, Krista M. Curcio, MT(ASCP), Ian Giles, MD, Richard Kendall, FIBMS, PhD, Rick Gooch, MBA, MT(ASCP)

793

Chapter 33

Coagulation Methods   Melissa Bethel, MT(ASCP)

849

Chapter 34

Applications of Flow Cytometry to Hematopathology   Donna M. Gandour, PhD

882

Chapter 35

Molecular Diagnostic Techniques in Hematopathology   Margaret L Gulley, MD

911

Chapter 36

Special Stains/Cytochemistry   Mary Loring Perkins, MS, MT(ASCP)SH, Denise M. Harmening, PhD, MT(ASCP), CLS(NCA), Frank Xianfeng Zhao, MD, PhD

929

 

Answers to Chapter Review Questions

951

 

Glossary

953

 

Bibliography

977

 

Index

981