9780813817989

Table of Contents


	Contributors	xv
	Preface to the Sixth Edition	xxiii
SECTION I	HEMATOPOIESIS Maxey L. Wellman	1
Chapter 1	Embryonic and Fetal Hematopoiesis Kelli L. Boyd and Brad Bolon	3
Chapter 2	Structure of Bone Marrow Leslie C. Sharkey and Sara A. Hill	8
Chapter 3	Stem Cell Biology Jed A. Overmann, Jaime F. Modiano, and Timothy O. O’brien	14
Chapter 4	Cluster of Differentiation (CD) Antigens Melinda J. Wilkerson and Cinzia Mastrorilli	20
Chapter 5	The Hematopoietic System Bruce D. Car	27
Chapter 6	Erythropoiesis Christine S. Olver	36
Chapter 7	Granulopoiesis M. Judith Radin and Maxey L. Wellman	43
Chapter 8	Monocytes and Dendritic Cell Production and Distribution Tracy L. Papenfuss	50
Chapter 9	Thrombopoiesis Mary K. Boudreaux	56
Chapter 10	Lymphopoiesis Mary JO Burkhard	61
Chapter 11	Vasculogenesis/Endothelial Progenitor Cells Debra A. Kamstock	65
SECTION II	HEMATOTOXICITY Douglas J. Weiss	69
Chapter 12	Design and Methods Used for Preclinical Hematotoxicity Studies William J. Reagan, Florence M. Poitout-Belissent, and Armando R. Irizarry Rovira	71
Chapter 13	Interpretation of Hematology Data in Preclinical Toxicological Studies Florence M. Poitout-Belissent and Jeffrey E. McCartney	78
Chapter 14	Preclinical Evaluation of Compound-Related Cytopenias Laurie G. O’rourke	85
Chapter 15	Preclinical Evaluation of Compound-Related Alterations in Hemostasis Kay A. Cri Swell	92
Chapter 16	Drug-Induced Blood Cell Disorders Douglas J. Weiss	98
Chapter 17	Myelonecrosis and Acute Inflammation Douglas J. Weiss	106
Chapter 18	Chronic Inflammation and Secondary Myelofibrosis Douglas J.Weiss	112
Chapter 19	Infectious Injury to Bone Marrow K. Janewardrop	118
SECTION III	ERYTHROCYTES Joanne B. Messick	121
Chapter 20	Erythrocyte Structure and Function Christine S. Olver, Gordon A. Andrews, Joseph E. Smith, and J. Jerry Kaneko	123
Chapter 21	Erythrocyte Biochemistry John W. Harvey	131
Chapter 22	Erythrokinetics and Erythrocyte Destruction John A. Christian	136
Chapter 23	Erythrocyte Morphology Anne M. Barger	144
Chapter 24	Laboratory and Clinical Diagnosis of Anemia Harold Tvedten	152
Chapter 25	Erythrocytosis and Polycythemia John F. Randolph, Mark E. Peterson, and Tracy Stokql	162
Chapter 26	Iron and Copper Deficiencies and Disorders of Iron Metabolism Douglas J.Weiss	167
Chapter 27	The Porphyrias and Porphyrinurias J. Jerry Kaneko	172
Chapter 28	Hereditary Erythrocyte Enzyme Abnormalities Urs Giger	179
Chapter 29	Erythrocyte Membrane Defects Mutsumilnaba and Joanne B. Messick	187
Chapter 30	Congenital Dyserythropoiesis Douglas J. Weiss	196
Chapter 31	Anemias Caused by Rickettsia, Mycoplasma, and Protozoa Robin W. Allison and James H. Meinkoth	199
Chapter 32	Anemia Associated with Bacteria and Viral Infections Casey M. Riegel and Steven L. Stockham	211
Chapter 33	Immune-Mediated Anemias in the Dog Michael J. Day	216
Chapter 34	Immune-Mediated Anemias in the Cat Tracy Stokol	226
Chapter 35	Immune-Mediated Anemias in Ruminants and Horses Kathy K. Seino	233
Chapter 36	Anemias Associated with Oxidative Injury Michel Desnoyers	239
Chapter 37	Anemia of Inflammatory, Neoplastic, Renal, and Endocrine Diseases Michael M. Fry	246
Chapter 38	Pure Red Cell Aplasia Douglas J.Weiss	251
Chapter 39	Aplastic Anemia Douglas J. Weiss	256
SECTION IV	LEUKOCYTES Erik Teske	261
Chapter 40	Neutrophil Structure and Biochemistry Mary B. Nabity and Shashi Kumar Ramaiah	263
Chapter 41	Neutrophil Distribution and Function Douglas J. Weiss, Shashi Kumar Ramaiah, and Bruce Walcheck	268
Chapter 42	Neutrophil Function Disorders Douglas J. Weiss	275
Chapter 43	Eosinophils and their Disorders Karen M. Young and Richard L. Meadows	281
Chapter 44	Basophils, Mast Cells, and their Disorders Usa M. Pohlman	290
Chapter 45	Monocytes and Macrophages and their Disorders Douglas J. Weiss and Cleverson D. Souza	298
Chapter 46	Interpretation of Ruminant Leukocyte Responses Susan J. Tornquist and Johanna Rigas	307
Chapter 47	Interpretation of Equine Leukocyte Responses Elizabeth G. Welles	314
Chapter 48	Interpretation of Canine Leukocyte Responses A. Eric Schultze	321
Chapter 49	Interpretation of Feline Leukocyte Responses Amy C. Valenciano, Lilli S. Decker, and Rick L. Cowell	335
Chapter 50	Determination and Interpretation of the Avian Leukogram Kenneth S. Latimer and Dorothee Bienzle	345
Chapter 51	Biology of Lymphocytes and Plasma Cells Michael J. Day	358
Chapter 52	Structure, Function, and Disorders of Lymphoid Tissue V.E. Ted Valli and Robert M. Jacobs	367
Chapter 53	Disorders of the Spleen John L. Robertson and Erik Teske	376
Chapter 54	Systemic Lupus Erythematosus Luc S. Chabanne	383
Chapter 55	Feline Immunodeficiency Virus Hans Lutz and Margaret Hosie	393
Chapter 56	T Cell, Immunoglobulin, and Complement Immunodeficiency Disorders Peter J. Felsburg	400
Chapter 57	Severe Combined Immunodeficiencies Steven E. Suter	406
Chapter 58	Benign Lymphadenopathies C. Guillermo Couto, Rance M. Gamblin, and Erik Teske	412
SECTION V	HEMATOLOGIC NEOPLASIA Jaime F. Modiano	419
Chapter 59	Cell Cycle Control in Hematopoietic Cells Jaime F. Modiano and Catherine A. St. Hill	421
Chapter 60	Epidemiology of Hematopoietic Neoplasia Michelle G. Ritt	427
Chapter 61	Genetics of Hematopoietic Neoplasia Jaime F. Modiano and Matthew Breen	433
Chapter 62	Transforming Retroviruses Mary JO Burkhard	440
Chapter 63	Bone Marrow-Derived Sarcomas Leslie C. Sharkey and Jaime F. Modiano	447
Chapter 64	Classification of Leukemia and Lymphoma V.E. Ted Valli and William Vernau	451
Chapter 65	General Features of Leukemia and Lymphoma Stuart C. Helfand and William C. Kisseberth	455
Chapter 66	Myelodysplastic Syndromes Douglas J.Weiss	467
Chapter 67	Acute Myeloid Leukemia Laura A. Snvder	475
Chapter 68	Mast Cell Cancer Cheryl London	483
Chapter 69	B Cell Tumors V.E, Ted Valli	491
Chapter 70	Plasma Cell Tumors Antonella Borgatti	511
Chapter 71	Hodgkin’s Lymphoma V.E. Ted Valli	520
Chapter 72	T Cell Lymphoproliferative Diseases Davis M. Seelig, Paul R. Avery, William C. Kisseberth, and Jaime F. Modiano	525
Chapter 73	Histiocytic Proliferative Diseases Peter F. Moore	540
Chapter 74	Gene Therapy Bruce F. Smith and R. Curtis Bird	550
SECTION VI	PLATELETS Mary K. Boudreaux	559
Chapter 75	Platelet Structure Mary K. Boudreaux	561
Chapter 76	Platelet Biochemistry, Signal Transduction, and Function Mary K. Boudreaux and James L. Catalfamo	569
Chapter 77	Platelet Kinetics and Laboratory Evaluation of Thrombocytopenia Karen E. Russell	576
Chapter 78	Immune-Mediated Thrombocytopenia Michael A. Scott and L. Ari Jutkowitz	586
Chapter 79	Non-Immune-Mediated Thrombocytopenia Jennifer S.Thomas	596
Chapter 80	Essential Thrombocythemia and Reactive Thrombocytosis Tracy Stokol	605
Chapter 81	Von Willebrand Disease Marjory B. Brooks and James L. Catalfamo	612
Chapter 82	Inherited Intrinsic Platelet Disorders Mary K. Boudreaux	619
Chapter 83	Acquired Platelet Dysfunction Michael M. Fry	626
SECTION VII	HEMOSTASIS Marjory B. Brooks	633
Chapter 84	Overview of Hemostasis Stephanie A. Smith	635
Chapter 85	Acquired Coagulopathies Marjory B. Brooks and Armelle De Laforcade	654
Chapter 86	Hereditary Coagulopathies Marjory B. Brooks	661
Chapter 87	Thrombotic Disorders Susan G. Hackner and Barbara Dallap Schaer	668
Chapter 88	Disseminated Intravascular Coagulation Tracy Stokol	679
Chapter 89	Vascular Diseases Sean P. McDonough	689
Chapter 90	Treatment of Hemostatic Defects Daniel F. Hogan and Marjory B. Brooks	695
Chapter 91	Overview of Avian Hemostasis Kendal E. Harr	703
SECTION VIII	TRANSFUSION MEDICINE Mary Beth Callan	709
Chapter 92	Erythrocyte Antigens and Blood Groups Gordon A. Andrews and Maria Cecilia T. Penedo	711
Chapter 93	Granulocyte and Platelet Antigens Jennifer S. Thomas	725
Chapter 94	Principles of Canine and Feline Blood Collection, Processing, and Storage Anthony C.G. Abrams-Ogg and Ann Schneider	731
Chapter 95	Red Blood Cell Transfusion in the Dog and Cat Mary Beth Callan	738
Chapter 96	Transfusion of Plasma Products Marjory B. Brooks	744
Chapter 97	Platelet and Granulocvte Transfusion Anthony C.G. Abrams-Ogg	751
Chapter 98	Blood Transfusion in Large Animals Margaret C. Mudge	757
Chapter 99	Blood Transfusion in Exotic Species James K. Morrisey	763
Chapter 100	Transfusion Reactions Nicole M. Weinstein	769
Chapter 101	Major Histocompatibility Complex Antigens Anne S. Hale and John A. Gerlach	776
Chapter 102	Hematopoietic Stem Cell Transplantation Raquel M. Walton	783
Chapter 103	Clinical Use of Hematopoietic Growth Factors Steven E. Suter	790
SECTION IX	SPECIES SPECIFIC HEMATOLOGY Rose F. Raskin and K. Jane Wardrop	797
Chapter 104	Normal Hematology of the Dog Theresa E. Rizzi, James H. Meinkoth, and Kenneth D. Clinkenbeard	799
Chapter 105	Normal Hematology of the Cat Theresa E. Rizzi, Kenneth D. Clinkenbeard, and James H. Meinkoth	811
Chapter 106	Normal Hematology of the Horse and Donkey Tanya M. Grondin and Shane F. Dewitt	821
Chapter 107	Normal Hematology of Cattle Darren Wood and Gerardo F. Quiroz-Rocha	829
Chapter 108	Normal Hematology of Sheep and Goats Stacey R. Byers and John W. Kramer	836
Chapter 109	Hematology of the Pig Catherine E. Thorn	843
Chapter 110	Hematology of Laboratory Animals Anne Provencher Bolliger, Nancy E. Everds, Kurt L. Zimmerman, David M. Moore, Stephen A. Smith, and Kirstin F. Barnhart	852
Chapter 111	Hematology of the Ferret Kurt L. Zimmerman, David M. Moore, and Stephen A. Smith	888
Chapter 112	Hematology of the Guinea Pig Kurt L. Zimmerman, David M. Moore, and Stephen A. Smith	893
Chapter 113	Hematology of the Mongolian Gerbil Kurt L. Zimmerman, David M. Moore, and Stephen A. Smith	899
Chapter 114	Hematology of the Syrian (Golden) Hamster Stephen A. Smith, Kurt L. Zimmerman, and David M. Moore	904
Chapter 115	Hematology of Camelids Susan J. Tornquist	910
Chapter 116	Hematology of Cervids Katie M. Boes	918
Chapter 117	Hematology of Water Buffalo (Bubalia Bubalis) Tamara B. Wills	927
Chapter 118	Hematology of the American Bison (Bison Bison) Kurt L. Zimmerman, David M. Moore, and Stephen A. Smith	931
Chapter 119	Hematology of Reindeer Bridget C. Garner	936
Chapter 120	Hematology of Elephants Kendal E. Harr, Ramiro Isaza, and Julia T. Blue	942
Chapter 121	Hematology of Marine Mammals Thomas H. Reidarson	950
Chapter 122	Hematology of Chickens and Turkeys Patricia S. Wakenell	958
Chapter 123	Hematology of Psittacines Terry W.Campbell	968
Chapter 124	Hematology of Waterfowl and Raptors Terry W. Campbell, Stephen A. Smith, and Kurt L. Zimmerman	977
Chapter 125	Hematology of Ratites Alice Blue-McLendon and Robert A. Green	987
Chapter 126	Hematology of Fishes Terry C. Hrubec and Stephen A. Smith	994
Chapter 127	Hematology of Reptiles Armando R. Irizarry Rovira	1004
Chapter 128	Hematology of Elasmobranchs Michael K. Stoskopf	1013
SECTION X	QUALITY CONTROL AND LABORATORY TECHNIQUES Andreas Moritz	1019
Chapter 129	Quality Control Mads Kjelgaard-Hansen and Asger Lundorff Jensen	1021
Chapter 130	Diagnostic Test Validation Asger Lundorff Jensen and Mads Kelgaard-Hansen	1027
Chapter 131	Reference Intervals Mads Kjelgaard-Hansen and Asger Lundorff Jensen	1034
Chapter 132	Evaluation of Bone Marrow Andreas Moritz, Natali B. Bauer, Douglas J. Weiss, Anne Lanevschi, and Alaa Saad	1039
Chapter 133	Hematopoietic Cell Culture Christine S. Olver	1047
Chapter 134	Radiolabeling and Scintigraphic Imaging of Platelets and Leukocytes Douglas J. Weiss	1051
Chapter 135	Automated Hematology Systems Andreas Moritz and Martina Becker	1054
Chapter 136	Reticulocyte and Heinz Body Staining and Enumeration Harold Tvedten and Andreas Moritz	1067
Chapter 137	Flow Cytometry Douglas J. Weiss and Melinda J. Wilkerson	1074
Chapter 138	Laboratory Testing of Coagulation Disorders George Lubas, Marco Caldin, Bo Wiinberg, and Annemarie T. Kristensen	1082
Chapter 139	Clinical Blood Typing and Crossmatching K. Jane Wardrop	1101
Chapter 140	Testing for Immune-Mediated Hematologic Disease K. Jane Wardrop, Melinda J. Wilkerson, and Cinzia Mastrorilli	1106
Chapter 141	Evaluation of Neutrophil Function Stefano Comazzi	1114
Chapter 142	Evaluation of Platelet Function Inge Tarnow and Annemarie T. Kristensen	1123
Chapter 143	Immunophenotyping and Determination of Clonality Anne C. Avery	1133
Chapter 144	Cytochemical Staining Rose E. Raskin	1141
Chapter 145	Electrophoresis and Acute Phase Protein Measurement Jose J. Cerón, Marco Caloin, and Silvia Martinez-Subiela	1157
Chapter 146	Measurement of Serum Iron Concentration, TIBC, and Serum Ferritin Concentration Gordon A. Andrews	1162
Chapter 147	Molecular Techniques and Real-Time PCR Christian M. Leutenegger	1165
Chapter 148	Genetic Evaluation of Inherited and Acquired Hematologic Diseases Christian M. Leutenegger and URS Giger	1170
	Index	1176