Preface

v

Acknowledgments

vii

Contributors

xiii

1

Fundamentals of Gas Exchange and the Assessment of Oxygenation and Ventilation   John S. Sullivan and Toah A. Nkromah

1

2

Oxygen Delivery and Oxygen Consumption in Pediatric Critical Care   Juan A. Gutierrez and Andreas A. Theodorou

19

3

Hemodynamics   Scott A. Hagen and Timothy E. Corden

39

4

Regional Circulations   Demetris Yannopoulos and Vinay M. Nadkarni

65

5

Assessment of Cardiovascular Function   Frank A. Maffei

94

6

Overview, Structure and Function of the Nephron   Megan Rashid and George J. Schwartz

133

7

Physiology of Skeletal Muscle and the Neuromuscular Junction   Ellen D. Iannoli and Michael P. Eaton

169

8

Assessment of Neurologic Function   Elizabeth E. Scarlett, Brandi N. Peachey, and Jill M. Gotoff

178

9

Endothelial Interactions and Coagulation   Trung C. Nguyen and Joseph A. Carcillo

202

10

The Inflammatory Response   Mark W. Hall

218

11

Genetic Predisposition to Critical Illness in the Pediatric Intensive Care Unit   Neal J. Thomas, Mary K. Dahmer, and Michael W. Quasney

242

12

Conventional Mechanical Ventilation   Joseph D. Tobias

262

13

Non-conventional Mechanical Ventilation   Michael D. Dettorre

285

14

Mechanical and Electrical Myocardial Support   Sabrina S.L. Tsao, Kendra M. Ward, and Denise M. Goodman

299

15

Renal Replacement Therapies and Other Extracorporeal Therapies   Andrew L. Schwaderer and Marc B. Lande

322

16

Pharmacology   Gretchen L. Brummel and Steven E. Lucking

334

17

Cardiovascular Drug Therapy   Frank. A. Maffei

352

18

Sedation and Analgesia   Richard L. Lambert, Lela W. Brink, and Frank A. Maffei

382

19

Neuromuscular Blockade   Michael P. Eaton and A. Marika Stone

406

20

Use of Blood Products   Jill M. Cholette and Norma B. Lerner

427

21

Nutrition in Critical Illness   Margaret A. Satchell

451

22

Upper Airway Obstruction   Steven E. Lucking

463

23

Severe Asthma   Neal J. Thomas and Frank A. Maffei

480

24

Acute Respiratory Distress Syndrome   Frank A. Maffei and Neal J. Thomas

499

25

Acute Pulmonary Infections   Karen S. Powers

514

26

Circulatory Failure/Shock   Hector R. Wong

535

27

Sepsis   Angela Lorts, Timothy T. Cornell, and Thomas P. Shanley

552

28

Multiple Organ Dysfunction Syndrome   Nlkoleta S. Kolovos and barry P. Markovitz

571

29

Disorders of Cardiac Rhythm   William G. Harmon

583

30

Post-operative Cardiac Care   Surender Rajasekaran and John C. Ring

607

31

Cerebral Resuscitation and Traumatic Brain Injury   Ericka L. Fink, Patrick M. Kochanek, and Robert S.B. Clark

643

32

Neurological Diseases in Pediatric Critical Care Medicine   Michael J. Bell and Aditi Sharangpani

668

33

The Approach to the Critically III Infant   Frank A. Maffei

690

34

Nosocomial Infections   Elise W. van der Jagt

713

35

Fluid/Electrolyte/Acid-Base Abnormalities   Michael L. Moritz

734

36

Acute Kidney Injury   William S. Varade and Elif Erkan

765

37

Acute Liver Injury and Failure in Children   Richard L. Lambert

784

38

Hematology and Oncology in Critical Illness   Leonardo R. Brandao, Scott C. Howard, Kenneth W. Gow, Surender rajasekaran, and robert F. Tamburro

801

39

Critical Care Endocrinology   Kecha A. Lynshue and Mark A. Sperling

851

40

Metabolic Crises   Paul J. Bellino

870

41

Trauma/Burn   Robert E. Cilley and Eric H. Bradburn

896

42

Toxicology for the Pediatric Intensivist   L. Eugene Daugiierty and Frank A. Maffei

912

Index

933