Table of Contents

 

 

 

 

Contributors

x

 

Preface

xxi

 

VOLUME 1

 

PART 1

BASIC MECHANISMS OF NORMAL AND ABNORMAL GASTROINTESTINAL FUNCTION

 

A

Components

 

1

Integrative Responses of the Gastrointestinal Tract and Liver to a Meal   Stephen J. Pandol, Helen E. Raybould, Hal F. Yee Jr

3

2

The Enteric Nervous System and its Extrinsic Connections   John B. Furness, Trung V. Nguyen, Kulmira Nurgali, Yasutake Shimizu

15

3

Sensory Neurons of the Gastrointestinal Tract   John B. Furness

40

4

Gastrointestinal Hormones and Receptors   Laurence J. Miller

56

5

The Brain-Gut Axis   Graham J. Dockray

86

6

Smooth Muscle of the Gut   Gabriel M. Makhlouf, Karnam S. Murthy

103

7

The Mucosal Immune System and Gastrointestinal Inflammation   Fahio Cominelli, Kristen O. Arseneau, Richards. Blumberg, William F. Stenson, Theresa T. Pizarro

133

8

Epithelia: Biological Principles of Organization   Jerrold R. Turner, James L. Madara

169

B

Motility

 

9

Esophageal Motor Function   Peter J. Kahrilas, John E. Pandolfino

187

10

The Physiology of Gastric Motility and Gastric Emptying   William L. Hosier

207

11

Motility of the Small Intestine and Colon   William L. Hosier

231

12

Motility of the Biliary Tract   Gary M. Mawe, Peter L. Moses, Gino T.P. Saccone, Maria J. Pozo

264

C

Secretion and Absorption

 

13

Gastric Secretion   John Del Valle, Andrea Todisco

284

14

Electrolyte Secretion and Absorption: Small Intestine and Colon   Stephen J. Keely, Marshall H. Montrose, Kim E. Barrett

330

15

Pancreatic Secretion   Chung Owyang, John A. Williams

368

16

Bile Secretion and Cholestasis   Steven A. Weinman, Sajid Jajil

401

D

Nutrition

 

17

Carbohydrate Assimilation   Eric Sibley

429

18

Intestinal Lipid Absorption   William Sun, Chun-Min Lo, Patrick Tso

445

19

Protein Digestion and Assimilation   Vadivel Ganapathy, Malliga E. Ganapathy, Frederick H. Leibach

464

20

Vitamins and Minerals   Charles H. Halsted, Mark A. Levine, Bo L. Lönnerdal, Robert B. Rucker

478

21

General Nutritional Principles   David H. Alpers, Beth Taylor, Samuel Klein

508

E

Miscellaneous

 

22

Gastrointestinal Blood Flow   Philip T. Nowicki, D. Neil Granger

540

23

Development of the Gastrointestinal System   Ben Z. Stanger, Daniel K. Podolsky

567

24

Neoplasia of the Gastrointestinal Tract   Barbara H. Jung, C. Richard Boland, John M. Carethers

603

25

The Human Intestinal Microbiota and Microbiome   Ruth E. Ley, Jeffrey I. Gordon

635

26

Drug Metabolism and Transport in the Liver and Intestine   Paul B. Watkins

645

27

Pathogenesis of Hepatic Fibrosis   Ramón Bataller, David A. Brenner

658

28

Hepatic regeneration   George K. Michalopoulos, Marie C. DeFrances

680

29

Molecular Biological Approaches to the Diagnosis and Treatment of Gastrointestinal Diseases   David A. Brenner, Robert Schwabe, Christoph Oesterreicher

703

PART 2

GASTROINTESTINAL DISEASES

 

A

Esophagus

 

30

Esophagus: Anatomy and Developmental and Structural Anomalies   Ikuo Hirano

719

31

Motility Disorders of the Esophagus   Peter J. Kahrilas, John E. Pandolfino

740

32

Gastroesophageal Reflux Disease   Joel E. Richter

772

33

Eosinophilic Esophagitis   Marc E. Rothenberg, Glenn T. Furuta

802

34

Esophageal Infections and Disorders Associated with Acquired Immunodeficiency Syndrome   C. Mel Wilcox

813

35

Barrett Esophagus and Esophageal Adenocarcinoma   Stuart Jan Spechler, Rhonda F. Souza

826

36

Esophageal Neoplasms   Weijing Sun, Anil K. Rustgi

849

37

Miscellaneous Diseases of the Esophagus: Foreign Bodies, Physical Injury, and Systemic and Dermatological Diseases   Evan S. Dellon, Nicholas J. Shaheen

871

B

Stomach

 

38

Stomach and Duodenum: Anatomy and Structural Anomalies   Jean-Pierre Kaufman, Eric Goldberg

889

39

Disorders of Gastric Emptying   Henry P. Parkman, Frank K. Friedenberg, Roberts Fisher

903

40

Peptic Ulcer Disease   Andrew H. Soil, David Y. Graham

936

41

Zollinger-Ellison Syndrome   John Del Valle

982

42

Gastritis and Gastropathy   Mary Kay Washington, Richard M. Peek Jr

1005

43

Tumors of the Stomach   Wai K. Leung, Enders K. W. Ng, Joseph J.Y. Sung

1026

44

Surgery for Peptic Ulcer Disease and Postgastreclomy Syndromes   Robert E. Glasgow, Sean J. Mulvihill

1054

45

Miscellaneous Diseases of the Stomach   John C. Rabine, Timothy T. Nostrant

1071

C

Small Intestine

 

46

Small Intestine: Anatomy and Structural Anomalies   Deborah C. Rubin

1085

47

Dysmotility of the Small Intestine and Colon   Michael Camilleri, Lawrence Szarka

1108

48

Bacterial, Viral, and Toxic Causes of Diarrhea, Gastroenteritis, and Anorectal Infections   Phillip I. Tarr, Dorsey M. Bass, Gail A. Hecht

1157

49

Chronic Infections of the Small Intestine   George T. Fantry, Lori E. Fantry, Stephen P. James

1225

50

Celiac Disease   Peter H.R. Green, Anne R. Lee

1245

51

Disorders of Epithelial Transport in the Small Intestine   Martín G. Martín, Ernest M. Wright

1259

52

Bacterial Overgrowth   Philip M. Sherman, Karen L. Madsen

1284

53

Short bowel Syndrome   Richard N. Fedorak, Lana Bistritz

1295

54

Tumors of the Small Intestine   Roberts. Bresalier, Sharmila Anandasabapathy

1322

55

Miscellaneous Diseases of the Small Intestine   Marc S. Levin, C. Prakash Gyawali

1343

D

Colon (for colonic infections see Chapter 48)

 

56

Colon: Anatomy and Structural Anomalies   Steven M. Cohn, Elisa H. Birnbaum, Charles M. Friel

1369

57

Inflammatory Bowel Disease   William F. Stenson, Stephen B. Hanauer, Russell D. Cohen

1386

58

Surgical Treatment of Inflammatory Bowel Disease   Emily Finlayson, Fabrizio Michelassi

1473

59

Miscellaneous Inflammatory and Structural Disorders of the Colon   Meredythe A. McNally, Thomas C. Smyrk, William J. Tremaine

1507

60

Irritable Bowel Syndrome   Chung Owyang

1536

61

Diverticular Disease of the Colon   Tonia M. Young-Fadok, Michael G. Sarr

1574

62

Colorectal Cancer Screening   Graeme P. Young, James E. Allison

1598

63

Neoplastic and Nonneoplastic Polyps of the Colon and Rectum   Finlay A. Macrae, Graeme P. Young

1611

64

Polyposis Syndromes   Randall W. Butt. Russell F. Jacoby

1640

65

Malignant Tumors of the Colon   Francis M. Giardiello, Stanley R. Hamilton

1669

66

Anorectal Diseases   Adil P. Bharucha, Arnold Wald

1717

 

Index

 

 

VOLUME 2

 

E

Pancreas

 

67

Pancreas: Anatomy and Structural Anomalies   David G. Heidt, Michael W. Mulholland, Diane M. Simeone

1745

68

Acute Pancreatitis   Mark Topazian, Stephen J. Pandol

1761

69

Chronic Pancreatitis   Chung Owyang, Matthew J. DiMagno

1811

70

Nonendocrine Tumors of the Pancreas   James J. Farrell, Howard A. Reber

1853

71

Endocrine Neoplasms of the Pancreas   Robert T. Jensen

1875

72

Hereditary Diseases of the Pancreas   Jonathan A. Cohn

1921

F

Gallbladder and Biliary Tract

 

73

Gallbladder and Biliary Tract: Anatomy and Structural Anomalies   Theodore H. Welling, Diane M. Simeone

1940

74

Gallstones   Cynthia W. Ko, Sum P. Lee

1952

75

Primary Sclerosing Cholangitis and Other Cholangiopathies   Kymberly D.S. Watt, Jayant A. Talwalkar, Russell H. Wiesner

1978

76

Cystic Diseases of the Liver and Biliary Tract   Jung W. Suh, Albert J. Chang, Shelly C Lu

2009

77

Tumors of the Biliary Tract   Christopher J. Smolock, Jeffrey A. Drebin

2022

78

Sphincter of Oddi Dysfunction (Postcholecystectomy Syndrome)   John O. Clarke, Anthony N. Kalloo

2043

G

Liver

 

79

Liver: Anatomy, Microscopic Structure, and Cell Types   Gary C. Kanel

2057

80

Acute Viral Hepatitis   Marc G. Ghany, T. Jake Liang

2073

81

Chronic Hepatitis B Viral Infection   Robert G. Gish, Stephen Locarnini

2112

82

Hepatitis C Virus Infection   Aijaz Ahmed, Emmet B. Keeffe

2139

83

Drug-induced Liver Disease   William M. Lee, Emmanuel Seremba

2167

84

Autoimmune Hepatitis   B. Jenny Heathcote

2184

85

Primary Biliary Cirrhosis   Marlyn J. Mayo, Dwain L. Thiele

2193

86

Hemochromatosis   Jacob Alexander, Kris V. Kowdley

2211

87

Metabolic Diseases of the Liver   Ronald J. Sokol

2223

88

Alcoholic Liver Diseases   Suthat Liangpunsakul, David W. Crabb

2247

89

Nonalcoholic Fatty Liver Disease   Arun J. Sanyal

2274

90

Ascites and its Complications   Guadalupe Garcia-Tsao

2302

91

Central Nervous System and Pulmonary Complications of end-stage Liver Disease   Javier Vaquero, Andres T. Blei, Roger F. Butterworth

2327

92

Liver Transplantation   Francis Y.K. Yao, Sandy Feng, Nathan M. Bass

2352

93

Hepatocellular Carcinoma   Lewis R. Roberts, Gregory J. Gores

2386

94

Liver Abscess   DavidS. Raiford

2412

95

Vascular Diseases of the Liver   Laurie D. DeLeve

2418

96

Experimental Therapies: Hepatocyte Transplantation, Gene Therapy, and Liver Assist Devices   Jayanta Roy-Chowdhury, Namita Roy-Chowdhury, Simon P. Horslen, Ira J. Fox

2432

97

Liver Biopsy and Histopathological Diagnosis   Sugantha Govindarajan, Maurizio Kanatini

2449

H

Abdominal Cavity

 

98

Abdominal Cavity: Anatomy, Structural Anomalies, and Hernias   Sareh Parangi, Richard A. Hodin

2480

99

Intraabdominal Abscesses and Fistulae   Paul Knechtges, Ellen M. Zimmermann

2494

100

Diseases of the Peritoneum, Retroperitoneum, Mesentery, and Omentum   Shawn D. Larson, B. Mark Evers

2505

I

Miscellaneous

 

101

Nutritional Supplementation   David H. Alpen, Beth Taylor, Samuel Klein

2525

102

Obesity   Louis A. Chaptini, Steven R. Peikin

2561

103

Eating Disorders   Henry C. Lin, Eric E. Stone

2574

104

Complications of AIDS and Other Immunodeficiency Slates   Phillip D. Smith, Edward N. Janoff

2588

105

Gastrointestinal Manifestations of Immunological Disorders   Fergus Shanahan

2612

106

Parasitic Diseases: Protozoa   Ellen hi, Samuel L. Stanley Jr

2632

107

Parasitic Diseases: Helminthes   Carlos Seas, Martin Monies, A. Clinton White Jr

2651

108

Gastrointestinal and Hepatic Manifestations of specific genetic disorders   Elizabeth M. Petty

2672

109

Gastrointestinal Manifestations of Systemic Diseases   Joel S. Levine

2711

110

Skin lesions Associated with Gastrointestinal and Liver Diseases   Matilde lorizzo, Joseph L. Jorizzo

2755

111

Oral Manifestations of Gastrointestinal Diseases   John C. Rabine, Timothy T. Nostrant

2774

112

Gastrointestinal Vascular Malformations or Neoplasms: Arterial, Venous, Arteriovenous, and Capillary   Mitchell S. Cappell

2785

113

Intestinal Ischemia   Julián Panés, Josep M. Piqué

2811

114

Radiation Injury in the Gastrointestinal Tract   Steven M. Cohn, Stephen J. Bickston

2831

115

Complementary and Alternative Medicine in Gastroenterology   Craig J. McClain, Gerald W. Dryden, Kristine Krueger

2844

PART 3

DIAGNOSTIC AND THERAPEUTIC MODALITIES IN GASTROENTEROLOGY

 

A

Endoscopic

 

116

Reprocessing of Gastrointestinal Endoscopes and Accessories   Gregory Zuccaro Jr

2863

117

Sedation and Monitoring for Gastrointestinal Endoscopy   Hala Fatima, Douglas K. Rex

2975

118

Upper Gastrointestinal Endoscopy   William R. Brugge

2888

119

Capsule and Small Bowel Endoscopy   C. Paul Swain

2903

120

Colonoscopy and Flexible Sigmoidoscopy   Jerome D. Waye, Christopher B. Williams, Sharmila Anandasabapathy

2917

121

Endoscopic Retrograde Cholangiopancreatography, Endoscopic Sphincterotomy and Stone Removal, and Endoscopic Biliary and Pancreatic Drainage   Tony E. Yusuf, Daniel K. Mullady, David L. Can-Locke

2933

122

Gastrointestinal Dilation and Stent Placement   James D. Lord, Richard A. Kozarek

2958

123

Preutancous Endoscopic Gastrostomy   Brian J. Dunkin, Jeffrey L. Ponsky

2974

124

Management of Upper Gastrointestinal Hemorrhage Related to Portal Hypertension   Paul J. Thuluvath

2987

125

Endoscopic Diagnosis and Treatment of Nonvariceal Upper Gastrointestinal Hemorrhage   David J. Bjorkman

3018

126

Endoscopic Therapy for Polyps and Tumors   Sergey V. Kantsevoy

3032

127

Laparoscopy and Laparotomy   Wenliang Chen, David W. Rattner

3049

B

Imaging

 

128

Plain and Contrast Radiology   Marc S. Levine, Stephen E. Rubesin, Hans Herlinger, IgorLaufer

3061

129

Diagnostic Sonography   Philip W. Rails, R. Brooke Jeffrey Jr, Robert A. Kane, Michelle L. Robbin

3083

130

Endoscopic Ultrasonography   Sanjay B. Jagannath, Marcia I. Canto

3113

131

Applications of Computed Tomography to the Gastrointestinal Tract   Karen M. Horton, Pamela T. Johnson, Elliot K. Fishman, Alec J. Megibow

3140

132

Magnetic Resonance Imaging   Diane Bergin, Donald G. Mitchell

3173

133

Positron Emission Tomography   Uri Ladabaum, Satoshi Minoshima

3212

134

Applications of Radionuclide Imaging in Gastroenterology   Harvey A. Ziessman

3226

135

Angiography   Kyung J. Cho

3246

136

Interventional Radiology   Kyung J. Cho

3269

C

Pathology

 

137

Endoscopic Mucosal Biopsy: Histopathological Interpretation   Elizabeth Montgomery, Anthony N. Kalloo

3299

D

Gastrointestinal Function Studies

 

138

Evaluation of Gastrointestinal Motility: Emerging Technologies   John W. Wiley, Chung Owyang

3393

139

Tests of Gastric and Exocrine Pancreatic Function and Absorption   William D. Chey, Matthew J. DiMagno, William Y. Chey

3414

140

Natural Orifice Translumenal Endoscopic Surgery (NOTES)   Samuel A. Giday, Anthony N. Kalloo

3431

 

Index