Contributors

viii

Preface

xiii

1

Transfusion in the New Millennium   Ennio C. Rossi and Toby L. Simon

1

SECTION I

BLOOD COMPONENTS AND DERIVATIVES

15

Part I

Red Blood Cells

17

2

Red Cell Production and Kinetics   Mark J. Koury

17

3

Regulation of Oxygen Delivery by Red Cells and Red Cell Substitutes   Christopher P. Stowell

29

4

Red Cell Metabolism and Preservation   Bjarte G. Solheim and John R. Hess

54

5

Red Cell Immunology and Compatibility Testing   W John Judd

69

6

Carbohydrate Blood Groups   Eldad A. Hod, Patrice F. Spitalnik, and Steven L Spitalnik

89

7

Rh and LW Blood Group Antigens   Connie M. Westhoff and Don L. Siegel

109

8

Other Protein Blood Groups   Petr Jarolim

121

9

Anemia and Red Blood Cell Transfusion   Jeffrey L Carson and Paul Hebert

131

Part II

Platelets

149

10

Platelet Production, Kinetics, and Hemostasis   Henry M. Kinder and Aaron Tomer

149

11

Platelet Immunology and Alloimmunization   Brian R. Curtis and Janice G. McFarland

168

12

Preparation, Preservation, and Storage of Platelet Concentrates   Ralph R. Vassallo, Jr.

187

13

Thrombocytopenia and Platelet Transfusion   Peter W. Marks

199

Part III

White Blood Cells

211

14

Neutrophil Production and Kinetics: Neutropenia and Neutrophilia   Thomas H. Price

211

15

Neutrophil Collection and Transfusion   Ronald G. Strauss

219

16

Leukocyte-Reduced Blood Components: Laboratory and Clinical Aspects   Darrell J. Triulzi and Walter H. Dzik

228

Part IV

Plasma

247

17

Composition and Mechanisms of Blood Coagulation and Fibrinolysis   Peter Hellstern

247

18

Immunoglobulins   Urs E. Nydegger

260

19

Preparation of Plasma Derivatives   Toby L Simon, Kirsten Seidel, and Albrecht Gröner

273

20

Plasma Transfusion and Use of Albumin   Simon J. Stanworth and Alan T. Tinmouth

287

Part V

Cell Kinetics

298

21

Applications of Cellular Radiolabeling in Transfusion Medicine   Larry J. Dumont, James P. AuBuchon, and Richard J. Davey

298

SECTION II

CLINICAL PRACTICE

319

Part I

Medical Patients

321

22

Autoimmune Hemolytic Anemia and Paroxysmal Nocturnal Hemoglobinuria   Thomas P. Duffy

321

23

Management of Immune Thrombocytopenia   Theodore E. Warkentin

344

24

Bleeding from Acquired Coagulation Defects and Antithrombotic Therapy   Thomas J. Raife, Jeffrey S. Rose, and Steven R. Lentz

376

Part II

Obstetric and Pediatric Patients

391

25

Fetal and Neonalal Hcmatopoiesis   Robert D. Christensen and Martha C. Sola-Visner

391

26

Obstetric Transfusion Practice   Humphrey H.H. Kanhai, Jos J.M. van Roosmalen, and Anneke Brand

406

27

Hemolytic Disease of the Fetus and Newborn   Bjarte G. Solheim and Morten Grönn

418

28

Congenital Disorders of Clotting Proteins and Hypercoagulable States in Pediatrics   Linda J. Butros and Prasad Mathew

426

29

Management of Congenital Hemolytic Anemias   Bruce I. Sharon

448

30

Blood Component Transfusions for Infants   Ronald C. Strauss

470

Part III

Oncology Patients

482

31

Transfusion Support for the Oncology Patient   Christopher A. Tormey and Edward L. Snyder

482

32

Hematopoietic Growth Factors (Cytokines)   W. Conrad Liles and David C Dale

498

33

Hematopoietic Progenitor Cells: Biology and Processing   Thomas Leemhuis and Ronald A. Sacher

508

34

Hematopoietic Progenitor Cells: Autologous Transplantation   Hooman H. Rashidi and Scott D. Rowley

521

35

Hematopoietic Progenitor Cells: Allogeneic Transplantation   Amin M. Alousi and Sergio A. Giralt

542

36

Umbilical Cord Blood: A Reliable Source of Stem and Progenitor Cells for Human Transplantation   Suhag H. Parikh and Joanne Kurtzberg

559

Part IV

Surgery Patients

566

37

Alternatives to Transfusion: Perioperative Blood Management   Lynne Uhl

566

38

Blood Components to Achieve Hemostasis for Surgery and Invasive Procedures   Walter H. Dzik

575

39

Transfusion Therapy in the Care of Trauma and Burn Patients   Ellen C. Omi and Richard L. Gamelli

589

40

Transfusion Therapy in Solid-Organ Transplantation   Glenn Ramsey

604

SECTION III

APHERESIS

615

41

Apheresis: Principles and Technology of Hemapheresis   Ronald O. Gilcher and James W. Smith

617

42

Therapeutic Plasma Exchange   Bruce C. McLeod

629

43

Specialized Therapeutic Hemapheresis and Phlebotomy   Robert Weinstein

652

SECTION IV

HAZARDS OF TRANSFUSION

681

Part I

Hemovigilance

683

44

Overview of Hemovigilance   Dorothy Stainsby, Jean-Claude Faber, Jan Jřrgensen

683

45

Immunomodulatory and Proinflammatory Effects of Allogeneic Blood Transfusion   Eleftherios C. Vamvakas, José O. Bordin, and Morris A. Blajchman

699

Part II

Infectious Hazards of Transfusion

718

46

Transfusion-Transmitted Hepatitis   Harvey J. Alter and Juan I. Estebati-Mur

718

47

Retroviruses and Other Viruses   John A.J. Barbara, and Brian C. Dow

746

48

Transfusion Transmission of Parasites   Bryan R. Spencer

760

49

Bacterial Contamination of Blood Products   Yam A. Park and Mark E. Brecher

773

50

Prion Diseases   Marc L. Turner

791

51

Pathogen Inactivation   Bjarte G. Solheim and Jerard Seghatchian

801

Part III

Noninfectious Hazards

811

52

Hemolytic Transfusion Reactions   Robertson D. Davenport

811

53

Febrile, Allergic, and Nonimmune Transfusion Reactions   Gregory J. Pomper

826

54

Transfusion-Associated Graft-vs-Host Disease   John E. Levine and James L.M. Ferrara

847

55

Transfusional Iron Overload   Sujit Sheth

858

56

Transfusion-Related Acute Lung Injury   Jonathan P. Wallis and Ulrich J.H. Sachs

870

SECTION V

CELL AND TISSUE THERAPY

885

57

HLA Antigens and Alleles   Thomas M. Williams

887

58

Tissue Banking   Jeanne V. Hinden, William F. Zaloga, and A. Bradley Eisenbrey

898

9

Adoptive Immunotherapy   Catherine M. Bollard and Helen E. Heslop

920

60

Gene Therapy in Transfusion Medicine   Emanuela M. Bruscia and Diane S. Krause

936

61

Tissue Engineering and Regenerative Medicine   Clay Quint and Laura Niklason

950

SECTION VI

DELIVERY OF TRANSFUSION AND TRANSPLANTATION SERVICES

973

62

Recruitment and Screening of Donors and the Collection, Processing, and Testing of Blood   Kendall P. Crookston, Susan L. Wilkinson, and Toby L. Simon

975

63

Current Legal Issues in Transfusion Medicine   Edward M. Mansfield, Thomas K. Berg, Kurt A. Leifheit, John Parker Sweeney and P. Robert Rigney

993

64

Current Good Manufacturing Practice   P. Ann Hoppe and Sheryl A. Kochman

1010

65

Transplant Organizations and Networks in the Regulation of Cellular Therapy Programs   Dennis L. Confer

1032

66

Hospital Transfusion Committee and Quality Assurance   Pamela Clark and Paul D. Mintz

1041

Index

1061