List of Contributors

vi

Preface

viii

1

Genetics and Genomics   Peter A. Kopp

1

2

Principles of Hormone Action   Melissa Westwood

24

3

Measuring Hormones, Molecular Tests and their Clinical Application   Jan M. Wit, Marcel Karperien and Bart E.P.B. Ballieux

40

4

Congenital Disorders of the Hypothalamo-Pituitary-Somatotrope Axis   Ameeta Mehta, Evelien F. Gevers and Mehul T. Dattani

60

5

Acquired Disorders of the Hypothalamo-Pituitary Axis   Kyriaki-Sandy Alatzoglou and Mehul T. Dattani

106

6

Evaluation of Growth Disorders   Jerry K. Wales

124

7

Management of Disordered Growth   Steven D. Chernausek

155

8

Evaluation and Management of Late Effects of Cancer Treatment   Helena K. Gleeson and Stephen M. Shalet

169

9

Evaluation and Management of Disorders of Sex Development   Leuan A. Hughes

192

10

Evaluation of Disordered Puberty   Mehul T. Dattani, Vaitsa Tziaferi and Peter C. Hindmarsh

213

11

Management of Disordered Puberty   Jakub Mieszczak, Christopher P. Houk and Peter A. Lee

239

12

The Thyroid   Rosalind S. Brown

250

13

The Adrenal Cortex and its Disorders   Walter L. Miller

283

14

Polyglandular Syndromes   Catherine J. Owen, Tim D. Cheetham and Simon H.S. Pearce

327

15

Disorders of Water Balance   David R. Repaske

343

16

The Parathyroid and Disorders of Calcium and Bone Metabolism   Jeremy Allgrove

374

17

Endocrine Neoplasia in Childhood   Joanne C. Blair

428

18

Diabetes Mellitus   Andrew W. Norris and Joseph J. Wolfsdorf

458

19

Hypoglycemia: Assessment and Management   Andrew Cotterill, David Cowley and Ristan Greer

505

20

Childhood Obesity   Michael Freemark

530

21

Polycystic Ovarian Syndrome   M. Isabel Hernandez and Verónica Mericq

559

22

Weight Regulation and Monogenic Obesity   I. Sadaf Farooqi

571

23

Ethical Issues in Clinical Pediatric Endocrinology   Leena Patel and Peter E. Clayton

578

Appendix

Syndrome-Specific Growth Charts

590

Index

599