Contributors

iv

Preface

vi

Acknowledgements

vii

PART 1

PRINCIPLES OF CLINICAL PHARMACOLOGY

1

Pharmacodynamics and Pharmacokinetics

3

2

Clinical Trials and Drug Development

12

PART 2

ASPECTS OF THERAPEUTICS

3

Drugs and Gastrointestinal Disease

21

4

Management of Coronary Artery Disease and its Complications

33

5

Primary and Secondary Prevention of Cardiovascular Disease

58

6

Drugs Used to Treat Respiratory Disease

78

7

Drugs Used to Treat Neurological Disease

89

8

Treatment of Psychiatric Disorders

108

9

Antimicrobial Therapy

124

10

HIV and Antiretroviral Treatment

148

11

Travel Medicine and Tropical Disease

160

12

Drugs and Endocrine Disease

171

13

Drugs and the Reproductive System

190

14

Drugs and the Urological System

199

15

Cancer Therapeutics

205

16

Immunopharmacology

217

17

Corticosteroids

225

18

Drugs and the Blood Including Anticoagulants and Thrombolytic Drugs

229

19

Drugs and Inflammatory Joint Disease

244

20

Anaesthesia and the Relief of Pain

254

PART 3

PRACTICAL ASPECTS OF PRESCRIBING

21

Clinical Pharmacokinetics: Dosage Individualisation

267

22

Influence of Renal and Hepatic Disease on Pharmacokinetics and Pharmacodynamics

273

23

Prescribing at Extremes of Age

278

24

Drugs in Pregnant and Breastfeeding Women

282

25

Pharmacoeconomics: The Economic Evaluation of New Drugs

290

26

Poisoning and Drug Overdose

297

27

Drugs You may Need in a Hurry

313

28

Prescribing and its Pitfalls

318

Index

326