Preface to the Sixth Edition

viii

Preface to the First Edition

ix

How to Get the Best Out of Your Textbox

x

1

Haemopoiesls

1

2

Erythropoiesls and General Aspects of Anaemia

15

3

Hypochromic Anaemias

33

4

Iron Overload

50

5

Megaloblasitic Anaemias and Other Macrocytic Anaemias

58

6

Haemolytic Anaemias

73

7

Genetic Disorders of Haemoglobin

88

8

The White Cells 1: Granulocytes, Monocytes and their Benign Disorders

108

9

The White Cells 2: Lymphocytes and their Benign Disorders

126

10

The Spleen

142

11

The Aetiology and Genetics of Haematological Mallgnancies

150

12

Management of Haematological Mallgnancy

166

13

Acute Myeloid Leukaemia

178

14

Chronic Myelold Leukaemia

191

15

The Non-Leukaemic Myeloproliferative Neoplasms

200

16

Myelodysplasisa

214

17

Acute Lymphoblastic Leukaemia

223

18

The Chronic Lymphoid Leukaemias

234

19

Hodgkin Lymphoma

245

20

Non-Hodgkin Lymphoma

253

21

Multiple Myeloma and Related Disorders

272

22

Aplastic Anaemia and Bone Marrow Failure

288

23

Stem Ceil Transplantation

297

24

Platelets; Blood Coagulation and Haemostasis

314

25

Bieeding Disorders Caused by Vascular and Platelet Abnormalities

330

26

Coagulation Disorders

345

27

Thrombosis and Antithrombotic Therapy

362

28

Haematological Changes in Systemic Disease

381

29

Blood Transfusion

397

30

Pregnancy and Neonatal Haematology

413

Appendices

1

Normal Values

424

2

World Health Organization Classification of Tumours of the Haematopoietic and Lymphoid Tissues

426

Index

431