Table of Contents

 

 

 

SECTION I

FETAL DEVELOPMENT, ASSESSMENT, AND DELIVERY

1

1

Fetal Lung Development   Bruce M. Schnapf and Scott M. Kirley

1

 

Stages of Lung Development

2

 

Postnatal Lung Growth

5

 

Factors Affecting Prenatal and Postnatal Lung Growth

7

 

Abnormal Lung Development

8

 

Pulmonary Hypoplasia

8

 

Alveolar Cell Development and Surfactant Production

8

 

Fetal Lung Liquid

9

2

Fetal Gas Exchange and Circulation   Michael P. Czervinske

13

 

Maternal-Fecal Gas Exchange

13

 

Cardiovascular Development

14

 

Fetal Circulation and Fetal Shunts

17

 

Transition to Extrauterine Life

18

3

Antenatal Assessment and High-Risk Delivery   Antoun Y. Khabbaz and J. Gerald Quirk

21

 

Maternal History and Risk Factors

21

 

Antenatal Assessment

26

 

Intrapartum Monitoring

28

 

High-Risk Conditions

28

4

Neonatal Assessment and Resuscitation   Craig Patrick Black

35

 

Preparation

36

 

Stabilizing the Neonate

36

 

Assessing the Neonate

38

 

Resuscitating the Neonace

40

SECTION II

ASSESSMENT AND MONITORING OF THE NEONATAL AND PEDIATRIC PATIENT

47

5

Examination and Assessment of the Neonatal Patient   Craig Patrick Black

47

 

Gestational Age and Size Assessment

48

 

Physical Examination

49

 

Neurologic Assessment

57

 

Laboratory Assessment

57

6

Examination and Assessment of the Pediatric Patient   Dennis E. Schellhaese

61

 

Patient History

61

 

Pulmonary Examination

63

 

Nonpulmonary Examination

68

 

Laboratory Testing

69

 

The Health Care Team

70

 

Case Studies

70

7

Pulmonary Function Testing and Bedside Pulmonary Mechanics   Michael P. Czervinske and Michael A. Gentile

73

 

Definitions

74

 

Special Considerations

74

 

Mechanics of Breathing in Newborns

75

 

Neonatal Pulmonary Function Testing in the Laboratory

76

 

Pediatric Pulmonary Function Testing in the Laboratory

79

 

Measuring Pulmonary Mechanics at the Bedside

83

 

Summary

87

8

Radiographic Assessment   J. David Ingram

91

 

Radiographic Technique

91

 

Normal Chest Anatomy

92

 

Positioning of Lines and Tubes

95

 

Airway Obstruction

95

 

Respiratory Distress in the Newborn

97

 

Atelectasis

99

 

Pneumonia

100

 

Asthma

101

 

Cystic Fibrosis

101

 

Acute Respiratory Distress Syndrome

102

 

Chest Trauma

102

9

Pediatric Flexible Bronchoscopy   Karl Kalavantavanich and Craig M. Schramm

104

 

Indications

105

 

Contraindications

107

 

Equipment

107

 

Preparation

108

 

Procedure

111

 

Postprocedural Monitoring and Complications

112

 

Equipment Maintenance

113

 

Comparison with Rigid Bronchoscopy

113

10

Invasive Blood Gas Analysis and Cardiovascular Monitoring   Robert M. Diblasi and Michael P. Czervinske

116

 

Blood Gas Sampling

117

 

Arterial Puncture

118

 

Capillary Blood Gas Samples

120

 

Arterial Catheters

122

 

Continuous Invasive Blood Gas Monitoring

125

 

Central Venous Catheters

125

 

Pulmonary Artery Catheterization

126

 

Noninvasive Measurement of Cardiac Output and Perfusion

129

 

Patient Information

130

 

Frequency

130

 

Blood Gas Interpretation

130

 

Abnormal Hemoglobin

133

11

Noninvasive Monitoring in Neonatal and Pediatric Care   Cynthia Jacobus

137

 

Pulse Oximetry

138

 

Transcutaneous Monitoring

140

 

Capnometry

141

 

Impedance Pneumography

143

 

Electrocardiography

144

 

Calorimetry

144

SECTION III

THERAPEUTIC PROCEDURES FOR TREATMENT OF NEONATAL AND PEDIATRIC DISORDERS

147

12

Oxygen Administration   Sherry L. Barnhart

147

 

Indications

148

 

Complications

148

 

Oxygen Administration

149

13

Aerosols and Administration of Medication   James B. Fink and Bruce K. Rubin

165

 

Neonatal and Pediatric Medication Delivery

166

 

Aerosol Administration in Nonintubated Infants and Children

167

 

Deposition in Intubated Infants

168

 

Aerosol Characteristics

168

 

Aerosol Delivery

170

 

Device Selection and Compliance

180

 

Emergency Bronchodilator Resuscitation

181

 

Mechanical Ventilation

182

 

Bronchodilator Administration

186

 

Home Care and Monitoring Compliance

187

 

Other Medications for Aerosol Delivery

188

 

Summary

190

14

Airway Clearance Techniques and Lung Volume Expansion   Brian K. Walsh

196

 

History and Current Status of Airway Clearance Techniques

197

 

Chest Physical Therapy Techniques

197

 

Chest Physical Therapy in the Newborn

201

 

Chest Physical Therapy in Young Children

201

 

Complications of Chest Physical Therapy

205

 

Selection of Patients for Chest Physical Therapy

207

 

Contraindications

209

 

Length and Frequency of Therapy

209

 

Therapy Modification

209

 

Monitoring during Therapy

210

 

Evaluation of Therapy

210

 

Documentation of Therapy

210

 

Incentive Spirometry

210

 

Intermittent Positive-Pressure Breathing

213

 

Future of Airway Clearance Therapy

215

15

Airway Management   Ian N. Jacobs, Mary M. Pettignano and Robert Pettignano

220

 

Intubation

221

 

Intubation Procedure

224

 

Extubation

232

 

Tracheotomy

234

 

Suctioning

242

16

Surfactant Replacement Therapy   Santina A. Zanelli and David Kaufman

246

 

The Discovery of Surfactant

246

 

Surfactant Physiology

247

 

Surfactant Dysfunction in Acute Lung Injury

252

 

Clinical Applications and Replacement

253

 

Future Directions

261

17

Mechanical Ventilators   Katherine Fedor

267

 

Ventilator Classification

268

 

Neonacal/Infant Critical Care Ventilators

274

 

Universal Neonacal/Infant/Pediatric/Adult Critical Care Ventilators

278

 

Home Care Ventilators

295

 

Summary

302

18

Continuous Positive Airway Pressure   Robert M. DiBlasi and Peter Richardson

305

 

Indications

306

 

Contraindications

308

 

Hazards and Complications

308

 

Physiologic Effects

308

 

Delivery Systems and Patient Interfaces

309

 

Management Strategies

314

 

Advancing Concepts

318

19

Mechanical Ventilation of the Neonate and Pediatric Patient   Brian K. Walsh and Robert M. DiBlasi

325

 

Objectives and Indications for Mechanical Ventilation

326

 

Types of Mechanical Ventilation

326

 

Flow and Pressure Waveform Patterns

330

 

Time Constants

331

 

Triggering

331

 

Modes of Ventilation

332

 

Managing Ventilator Settings

335

 

Patient-Ventilator Interface

339

 

Complications of Mechanical Ventilation

340

 

Monitoring during Mechanical Ventilation

343

 

Weaning from Mechanical Ventilation

345

 

Advancing Concepts

347

20

Neonatal and Pediatric High-Frequency Ventilation   Keith S. Meredith and Mark Rogers

353

 

Definitions

354

 

Mechanisms of Gas Exchange

355

 

Indications

358

 

Ventilator Settings

359

 

High-Frequency Ventilators on the U.S. Market

360

 

Ventilator Management

362

 

Clinical Management Strategies

363

 

Weaning

365

 

Care of the Patient

367

 

Circuits and Humidification

367

 

Troubleshooting

368

 

Emerging Clinical Applications

368

21

Noninvasive Mechanical Ventilation of the Infant and Child   Pradip Kamat and W. Gerald Teague

373

 

Objectives of Noninvasive Ventilation

374

 

Experience with NPPV in Pediatric Patients

375

 

Noninvasive Ventilation with Positive-Pressure Devices

377

 

Noninvasive Ventilation with Negative-Pressure Devices

378

 

NPPV Modes

378

 

Monitoring the Patient and Ventilator Circuit

379

 

Pressure Titration in Noninvasive Ventilation

379

 

Interface Selection and Fit

380

 

Complications and Contraindications to NPPV

380

 

Future of Noninvasive Ventilation

381

22

Administration of Gas Mixtures   Mark Rogers

384

 

Nitric Oxide

385

 

Helium-Oxygen Mixtures

389

 

Hypoxic and Hypercarbic Gas Mixtures

391

 

Anesthetic Mixtures

392

23

Extracorporeal Life Support   Douglas R. Hansell

397

 

History

398

 

Neonatal Treatment

399

 

Pediatric Treatment

402

 

Extracorporeal Physiology

402

 

Extracorporeal Life Support Circuit

406

 

Cannulation

410

 

Management and Monitoring

411

 

Weaning

413

 

Decannulation

413

 

Complications

413

24

Pharmacology   Robert G. Aucoin

417

 

β-Adrenergic Agonists

418

 

Anticholinergics

423

 

Inhaled Corticosteroids

424

 

Systemic Corticosteroids

427

 

Leukotriene Modifiers

427

 

Methylxanthines

429

 

Magnesium Sulfate

430

 

Nonsteroidal Antiinflammatory Drugs

430

 

Mucolytic Agents

431

 

Ketamine

432

 

Aerosolized Antibiotics

433

 

Antiviral Agents

433

 

Monoclonal Anti-IgE Antibody Therapy

434

25

Thoracic Organ Transplantation   George B. Mallory, Jr., Okan Elidemir and Marc G. Schecter

439

 

Heart Transplantation

441

 

Heart-Lung Transplantation

442

 

Lung Transplantation

442

 

Immunosuppressive Regimens

443

 

Complications

444

 

Role of the Respiratory Therapist

448

26

Pediatric Advanced Life Support   Patrice Johnson and Kim Stevenson

451

 

Respiratory Distress, Respiratory Failure, and Respiratory Arrest

451

 

Shock and the Relationship with Respiratory Failure

452

 

Rapid Cardiopulmonary Assessment

452

 

Initial Assessment of Appearance

453

 

Initial Assessment of Airway/Breathing

454

 

Initial Assessment of Circulation

454

SECTION IV

NEONATAL AND PEDIATRIC DISORDERS: PRESENTATION, DIAGNOSIS, AND TREATMENT

461

27

Neonatal Pulmonary Disorders   Thomas L. Miller, Thomas H. Shaffer and Jay S. Greenspan

461

 

Respiratory Distress Syndrome

462

 

Transient Tachypnea of the Newborn

466

 

Neonatal Pneumonia

467

 

Meconium Aspiration Syndrome

470

 

Persistent Pulmonary Hypertension of the Newborn

473

 

Apnea of Prematurity

475

28

Surgical Disorders in Childhood that Affect Respiratory Care   Scott Keckler and Kurt P. Schropp

482

 

Choanal Atresia

483

 

Macroglossia

483

 

Mandibular Hypoplasia

484

 

Esophageal Atresia and Tracheoesophageal Fistula

484

 

Congenital Diaphragmatic Hernia

486

 

Chest Wall Malformations

487

 

Lung Bud Anomalies

488

 

Gastroschisis/Omphalocele

493

 

Necrotizing Enterocolitis

494

29

Neonatal Complications of Respiratory Care   Charles L. Paxson, Jr.

498

 

Clinical Presentations of Chronic Lung Disease

499

 

Diagnosis of Chronic Lung Disease

501

 

Pathophysiology

501

 

Treatment of Chronic Lung Disease

505

 

Retinopathy of Prematurity

508

 

Intraventricular Hemorrhage

509

30

Congenital Cardiac Defects   John Salyer, Teodor D. Butiu and David N. Crotwell

517

 

Cardiopulmonary Anatomy and Physiology

518

 

Classification of Cardiac Anomalies

520

 

Congenital Cardiac Anomalies

520

 

Left Ventricular Outflow Tract Obstruction

524

 

Clinical Monitoring of Patients with Cardiac Anomalies

537

 

Respiratory Care of Patients with Cardiac Anomalies

538

31

Sudden Infant Death Syndrome and Pediatric Sleep Disorders   Pearl Yu

543

 

Normal Control of Breathing and Heart Rate

545

 

Etiology

545

 

Tests to Assess Risk of Sudden Infant Death Syndrome

545

 

Polysomnographic Parameters

546

 

Laboratory Supervision

547

 

Setting

548

 

Personnel

548

 

Normal Sleep Development

549

 

Apnea

549

 

Home Cardiorespiratory Monitors

551

32

Pediatric Airway Disorders and Parenchymal Lung Diseases   Brian K. Walsh and Nico Vehse

554

 

The Pediatric Airway

555

 

Airway Obstruction

556

 

Upper Airway Disorders

557

 

Lower Airway Disorders

562

 

Pneumonia

571

 

Tuberculosis

575

 

Sickle Cell Disease

577

 

Recurrent Aspiration Syndrome

578

33

Asthma   Thomas J. Kallstrom and Maridee Jones

582

 

Pathogenesis of Asthma

583

 

Risk Factors for Development of Asthma in Children

584

 

National Asthma Education and Prevention Program Guidelines

585

 

Diagnosis

586

 

Management of Asthma

587

 

Managing Asthma Exacerbations in the Emergency Department

594

 

Hospitalization and Respiratory Failure

595

 

Exercise-Induced Bronchospasm

595

 

Asthma at School

596

 

Asthma Camps

597

34

Cystic Fibrosis   Bruce M. Schnapf

599

 

Genetics

600

 

Diagnosis

601

 

Pulmonary Disease

602

 

Treatment of Pulmonary Disease

604

 

Other Clinical Manifestations

606

 

Prognosis

607

35

Acute Respiratory Distress Syndrome   Ira Cheifetz and Jennifer L. Turi

611

 

Definition

611

 

Etiology

612

 

Prevalence

612

 

Clinical Course

612

 

Pathology and Role of Immunomodulators

614

 

Pulmonary Mechanics

615

 

Treatment/Ventilatory Support

615

 

Adjunct Therapies

617

 

Summary

618

36

Shock and Anaphylaxis   Cynthia L. Gibson and Anthony D. Slonim

621

 

Shock

621

 

Anaphylaxis

631

 

Summary

632

37

Sepsis and Meningitis   Julie Lynn Fitzgerald and Tracy Koogler

635

 

Sepsis

635

 

Meningitis

639

 

Summary

640

38

Thermal and Inhalation Injury   Ronald P. Mlcak

643

 

Thermal Injury

643

 

Inhalation Injury

646

 

Long-Term Outcomes

651

39

Head Injury and Cerebral Disorders   Paul Mathews

654

 

Causes and Anatomic Considerations

655

 

Initial Assessment and Diagnosis

656

 

Stabilization

659

 

Neurologic Assessment

661

 

Treatment Plan

665

 

Cerebral Disorders

666

 

Increased Intracranial Pressure

668

 

Status Epilepticus

671

40

Thoracic Trauma in Children   Bradley M. Rodgers and Eugene D. McGahren

674

 

Birth Trauma

674

 

Blunt Thoracic Trauma

675

 

Penetrating Thoracic Trauma

676

 

Latrogenic Thoracic Trauma

678

41

Drowning in Children   Kristina H. Deeter and John K. McGuire

683

 

Incidence

684

 

Pathophysiology

684

 

Treatment

685

 

Outcome

689

 

Prevention

689

42

Pediatric Poisoning   Kathleen D. Bongiovanni

692

 

Epidemiology

692

 

General Management

693

 

Common Poisoning Agents

695

 

Note on Cough and Cold Preparations

703

43

Disorders of the Pleura   Paul C. Stillwell

706

 

Pleural Effusions

707

 

Pneumothorax

709

 

Thoracostomy Drainage

710

 

Surgery in the Pleural Space

713

44

Neurologic and Neuromuscular Disorders   Mary E. Hartman, Peter H. Michelson and Michael P. Czervinske

716

 

Neuromuscular Control of Respiration

717

 

Neuromuscular Diseases that Affect the Respiratory System

718

 

Respiratory Evaluation of Children with Neuromuscular Disease

722

 

Respiratory Care of Children with Neuromuscular Disease

723

 

Transition to Adulthood

727

SECTION V

NEONATAL AND PEDIATRIC TRANSIENT AND AMBULATORY CARE

731

45

Transport of Infants and Children   Garry Sitler

731

 

Team Composition

732

 

Modes of Transportation

733

 

Equipment

735

 

Patient Assessment and Stabilization

736

 

Advanced Transport

737

 

Safety of Transport

738

 

Accreditation

738

46

Home Care   Sherry L. Barnhart

740

 

Discharge Planning: the Decision to Go Home

741

 

Oxygen Therapy at Home

745

 

Apnea-Bradycardia Monitors

747

 

Pulse Oximeters

749

 

The Child with a Tracheostomy

749

 

Mechanical Ventilation in the Home

754

 

A Successful Transition Home

758

 

Credits

761

 

Index

766