SECTION I

SCIENTIFIC OVERVIEW AND DEVELOPMENTAL PERSPECTIVES

1

Chapter 1

Gastrointestinal Development: Morphogenesis and Molecular Mechanisms   Robert K. Montgomery, PhD

3

Chapter 2

Dietary Regulation of Gene Expression   Ian R. Sanderson, MD, MSc, FRCP, FRCPCH

28

Chapter 3

The Exocrine Pancreas   Steven L. Werlin, MD and Alan Mayer, MD

42

Chapter 4

Innate Immunity and Epithelial Biology: Special Considerations in the Neonatal Gut   Patricia W. Lin, MD and Andrew S. Neish, MD

51

Chapter 5

The Intestinal Microbiota and the Microbiome   Brika C. Claud, MD and W. Allan Walker, MD

73

Chapter 6

Intestinal Barrier Function: Implications for the Neonate and Beyond   Ricardo A. Caicedo, MD, Martha Douglas-Escobar, MD, Nan Li, MD and Josef Neu, MD

93

Chapter 7

Intestine as a Neuro-Endocrine Organ   Carol Lynn Berseth, MD

111

Chapter 8

Trophic Factors in the Neonatal Gastrointestinal Tract   Michael Janeczko, MD and Douglas G. Burrin, PhD

121

Chapter 9

Cholestasis in Neonates and Infants   Michael K. Davis, MD and Joel M. Andres, MD

135

SECTION II

NUTRITION

163

Chapter 10

Regulation of Protein Synthesis and Proteolysis in the Neonate by Feeding   Tracy Gautsch Anthony, PhD and Susan Hazels Mitmesser, PhD

165

Chapter 11

Noninvasive Techniques to Monitor Nutrition in Neonates   Dominique Darmaun, MD, PhD and Jean-Christophe Rozé, MD

193

Chapter 12

Nutritional Requirements of the Very Low Birth Weight Infant   Patti J. Thureen, MD and William W. Hay, Jr., MD

208

Chapter 13

Macro and Micronutrients   Frank R. Greer, MD

223

Chapter 14

Diverse Roles of Lipids in Neonatal Physiology and Development   Nancy Auestad, PhD

253

SECTION III

SELECT CLINICAL ENTITIES

279

Chapter 15

Necrotizing Enterocolitis: Pathogenesis, Clinical Care and Prevention   Josef Neu, MD and Martha Douglas-Escobar, MD

281

Chapter 16

Short Bowel Syndrome   J. Marc Rhoads, MD

292

Chapter 17

Short Bowel Syndrome and Intestinal Tissue Engineering   Mike K. Chen, MD

310

Chapter 18

Adult Consequences of Neonatal and Fetal Nutrition: Mechanisms   Kjersti Aagaard-Tillery, MD, PhD and Nicole Mitchell, MD and Clotilde desRoberts, MD and Robert H. Lane, MD

318

Index

353