Color Plate Section Follows Chapter 13

List of Contributors

xi

Series Foreword

xvii

Preface

xix

PART 1

HEMODYNAMICS   Istvan Seri, MD, PhD

SECTION 1

PATHOPHYSIOLOGY OF NEONATAL SHOCK

1

Chapter 1

Etiology, Pathophysiology, and Phases of Neonatal Shock   Shahab Noori, MD and Istvan Seri, MD, PhD

3

Chapter 2

Autoregulation of Vital and Nonvital Organ Blood Flow in the Preterm and Term Neonate   Gorm Greisen, MD, PhD

19

Chapter 3

Definition of Normal Blood Pressure Range: The Elusive Target   William D. Engle, MD

39

SECTION 2

DIAGNOSIS OF NEONATAL SHOCK

67

Chapter 4

Use of Organ Blood Flow Assessment in the Diagnosis and Treatment of Neonatal Shock   Gorm Greisen MD, PhD

69

Chapter 5

Functional Echocardiography in the Neonatal Intensive Care Unit   Nicholas J. Evans, DM, MRCPCH

83

Chapter 6

Near-Infrared Spectroscopy and its Use for the Assessment of Tissue Perfusion in the Neonate   Suresh Victor, MRCPCH, PhD and Michael Weindling, MA, MD, BSC, FRCP, FRCPCH, HON FRCA

110

Chapter 7

Advanced Magnetic Resonance Neuroimaging Techniques in the Neonate with a Focus on Hemodynamic-Related Brain Injury   Ashok Panigrahy, MD and Stefan Bluml, PhD

133

SECTION 3

CLINICAL PRESENTATIONS OF NEONATAL SHOCK

145

Chapter 8

Clinical Presentations of Neonatal Shock: The VLBW Infant during the First Postnatal Day   Martin Kluckow, MBBS, PhD and Istvan Seri, MD, PhD

147

Chapter 9

The Very Low Birth Weight Neonate with a Hemodynamically Significant Ductus Arteriosus during the First Postnatal Week   Shahab Noori, MD and Istvan Seri, MD, PhD

178

Chapter 10

The Preterm Neonate with Relative Adrenal Insufficiency and Vasopressor-Resistant Hypotension   Cynthia Cole, MD, MPH

195

Chapter 11

Clinical Presentations of Systemic Inflammatory Response in Term and Preterm Infants   Rowena G. Cayabyab, MD and Istvan Seri, MD, PhD

208

Chapter 12

Shock in the Surgical Neonate   Philippe Friedlich, MBA, MD, MS Epi, Cathy Shin, MD, FACS, FAAP, Catarina Tiozzo, MD and Istvan Seri, MD, PhD

217

SECTION 4

WHERE IS THE EVIDENCE?

227

Chapter 13

Evidence-Based Evaluation of the Management of Neonatal Shock   David M. Osborn, MBBS, MM, FRACP, PhD

229

PART 2

CARDIOLOGY   Charles S. Klienman, MD

SECTION 5

CARDIOLOGY

267

Chapter 14

Prevalence of Congenital Heart Disease   Joel I. Brenner, MD

269

Chapter 15

Impact of Congenital Heart Disease and Surgical Intervention on Neurodevelopment   Mary T. Donofrio, MD, FAAP, FACC, FASE

275

Chapter 16

Obstetric Management of Fetuses with Congenital Heart Disease   Heather S. Lipkind, MD and Lynn L. Simpson, MD

297

Chapter 17

Fetal Cardiac Intervention   Mark K. Friedberg, MD, Norman H. Silverman, MD DSc (Med) FACC FASE, Frank L. Hanley, MD, Vadiyala Mohan Reddy, MD and Craig T. Albanese, MD, MBA

308

Chapter 18

Impact of Prenatal Diagnosis on the Management of Congenital Heart Disease   Charles S. Kleinman, MD

323

Chapter 19

Neonatal Interventional Catheterizations   Carl P. Garabedian, MD and William E. Hellenbrand, MD

339

Chapter 20

Cardiac Surgery in the Neonate with Congenital Heart Disease   Ryan R. Davies, MD, Jonathan M. Chen, MD, Jan M. Quaegebeur, MD, PhD and Ralph S. Mosca, MD

355

Chapter 21

MRI Evaluation of the Neonate with Congenital Heart Disease   Beth Feller Printz, MD, PhD

376

Chapter 22

The Twin-Twin Transfusion Syndrome: Evolving Concepts   Jack Rychik, MD

387

Index

403