Table
of Contents
|
|
|
|
|
SECTION I |
INTRODUCTION TO MOLECULAR MEDICINE |
1 |
|
1 |
Molecular
Basis of Human Disease Ivor J. Benjamin |
2 |
|
SECTION II |
EVIDENCE-BASED MEDICINE |
15 |
|
2 |
Evidence-Based
Medicine, Quality of Life, and the Cost of
Medicine Sara G. Tariq and
Susan S. Beland |
16 |
|
SECTION III |
CARDIOVASCULAR DISEASE |
21 |
|
3 |
Structure
and Function of the Normal Heart and Blood Vessels Jack Morshedzadeh,
Dean Y. Li and Ivor
J. Benjamin |
22 |
|
4 |
Evaluation
of the Patient with Cardiovascular Disease Sheldon E. Litwin
and Ivor J. Benjamin |
32 |
|
5 |
Diagnostic
Tests and Procedures in the Patient with Cardiovascular Disease Sheldon E. Litwin |
46 |
|
6 |
Heart
Failure and Cardiomyopathy Sheldon E. Litwin and Ivor J. Benjamin |
66 |
|
7 |
Congenital
Heart Disease Kevin J. Whitehead |
75 |
|
8 |
Acquired Valvular Heart
Disease Sheldon E. Litwin |
84 |
|
9 |
Coronary
Heart Disease Andrew D. Michaels |
95 |
|
10 |
Cardiac
Arrhythmias Mohamed H. Hamdan |
118 |
|
11 |
Pericardial
and Myocardial Disease Josef Stehlik
and Ivor J. Benjamin |
145 |
|
12 |
Other
Cardiac Topics David A. Bull and Ivor J. Benjamin |
156 |
|
13 |
Vascular
Diseases and Hypertension Wanpen Vongpatanasin
and Ronald G. Victor |
165 |
|
SECTION IV |
PULMONARY AND CRITICAL CARE MEDICINE |
187 |
|
14 |
The Lung in
Health and Disease Sharon
Rounds and Matthew D. Jankowich |
188 |
|
15 |
General
Approach to Patients with Respiratory Disorders Brian Casserly
and Sharon Rounds |
192 |
|
16 |
Evaluating
Lung Structure and Function F. Dennis McCool |
198 |
|
17 |
Obstructive
Lung Diseases Matthew D. Jankowich |
213 |
|
18 |
Interstitial
Lung Diseases Jason M. Aliotta
and Matthew D. Jankowich |
225 |
|
19 |
Pulmonary
Vascular Disease Sharon
Rounds |
241 |
|
20 |
Disorders
of Respiratory Control Sharon
Rounds and Matthew D. Jankowich |
245 |
|
21 |
Disorders
of the Pleura, Mediastinum,
and Chest Wall F. Dennis McCool |
248 |
|
22 |
Infectious
Diseases of the Lung Brian Casserly
and Sharon Rounds |
254 |
|
23 |
Essentials
in Critical Care Medicine Brian Casserty
and Sharon Rounds |
259 |
|
24 |
Neoplastic Disorders of the
Lung Matthew D. Jankowich
and Jason M. Aliotta |
266 |
|
SECTION V |
PREOPERATIVE AND POSTOPERATIVE CARE |
273 |
|
25 |
Preoperative
and Postoperative Care Wel C.
Lau and Kim A. Eagle |
274 |
|
SECTION VI |
RENAL DISEASE |
|
|
26 |
Elements of
Renal Structure and Function Robert L. Safirstein |
286 |
|
27 |
Approach to
the Patient with Renal Disease Michelle W. Krause, Thomas A. Golper,
Raymond C. Harris and Sudhir
V. Shah |
298 |
|
28 |
Fluid and
Electrolyte Disorders Thomas E. Andreoli
and Robert L. Safirstein |
305 |
|
29 |
Glomerular Diseases Jamie P. Dwyer and Julia B. Lewis |
323 |
|
30 |
Major Nonglomerular
Disorders James L. Pirkle,
Amanda W. Basford
and Roy Zent |
333 |
|
31 |
Vascular
Disorders of the Kidney James M. Luther and Gerald Schulman |
345 |
|
32 |
Acute
Kidney Injury Didier Portilla
and Sudhir V. Shah |
359 |
|
33 |
Chronic
Renal Failure Kerri
Cavanaugh and T. Alp Ikizler |
369 |
|
SECTION VII |
GASTROINTESTINAL DISEASE |
381 |
|
34 |
Common
Clinical Manifestations of Gastrointestinal Disease |
382 |
|
A |
Abdominal
Pain Charles M. Bliss, Jr. and
M. Michael Wolfe |
382 |
|
B |
Gastrointestinal
Hemorrhage T. Carlton Moore, Chi-Chuan Tseng and
M. Michael Wolfe |
385 |
|
C |
Malabsorption Marcos C. Pedrosa and Elihu
M. Schimmel |
389 |
|
D |
Diarrhea Satish K. Singh |
396 |
|
35 |
Endoscopic and Imaging
Procedures Brian C. Jacobson and Daniel S. Mishkin |
401 |
|
36 |
Esophageal
Disorders Robert C.
Lowe and M. Michael Wolfe |
408 |
|
37 |
Diseases of
the Stomach and Duodenum Wanda P. Blanton, Jaime A. Oviedo and M. Michael Wolfe |
414 |
|
38 |
Inflammatory
Bowel Disease Christopher
S. Huang and Francis A. Farraye |
430 |
|
39 |
Neoplasms of the Gastrointestinal Tract Paul C. Schroy III |
439 |
|
40 |
Diseases of
the Pancreas David R. Lichtenstein |
445 |
|
SECTION VIII |
DISEASES OF THE LIVER AND BILIARY SYSTEM |
455 |
|
41 |
Laboratory
Tests in Liver Disease Rajan Kochar
and Michael B. Fallon |
456 |
|
42 |
Jaundice Klaus Mönkemüller,
Helmut Neumann and Michael B. Fallon |
460 |
|
43 |
Acute and
Chronic Hepatitis Rajan Kochar, Aasim
M. Sheikh and Michael B. Fallon |
466 |
|
44 |
Fulminant Hepatic Failure Brendan M. McGuire and Michael B.
Fallon |
476 |
|
45 |
Cirrhosis
of the Liver and its Complications Rajan Kochar,
Miguel R. Arguedas
and Michael B. Fallon |
478 |
|
46 |
Disorders
of the Gallbladder and Biliary
Tract Shyam Varadarajulu,
Rudolf Garcia-Gallont and Michael B.
Fallon |
488 |
|
SECTION IX |
HEMATOLOGIC DISEASE |
495 |
|
47 |
Hematopoiesis and Hematopoietic
Failure Eunice S. Wang and Nancy Berliner |
496 |
|
48 |
Clonal Disorders of the Hematopoietic Stem Cell Eunice S. Wang and Nancy Berliner |
507 |
|
49 |
Disorders
of Red Blood Cells Michal G. Rose and Nancy Berliner |
520 |
|
50 |
Clinical
Disorders of Neutrophils Michal G. Rose and Nancy Berliner |
533 |
|
51 |
Disorders
of Lymphocytes Jill Lacy
and Stuart Seropian |
539 |
|
52 |
Normal Hemostasis Christine
S. Rinder
and Henry M. Rinder |
555 |
|
53 |
Disorders
of Hemostasis:
Bleeding Christopher
A. Tormey
and Henry M. Rinder |
564 |
|
54 |
Disorders
of Hemostasis:
Thrombosis Richard
Torres and Henry M. Rinder |
580 |
|
SECTION X |
ONCOLOGIC DISEASE |
593 |
|
55 |
Cancer
Biology and Etiologic Factors Alok A.
Khorana and Barbara A. Burtness |
594 |
|
56 |
Cancer
Epidemiology and ancer
Prevention Paula M. Lantz and Jennifer J. Griggs |
598 |
|
57 |
Solid
Tumors Robert F. Todd Iii and Jennifer J. Griggs |
603 |
|
58 |
Complications
of Cancer and Cancer Treatment Alok A.
Khorana and Jennifer J. Griggs |
616 |
|
59 |
Principles
of Cancer Therapy Alok A. Khorana
and Barbara A. Burtness |
621 |
|
SECTION XI |
METABOLIC DISEASE |
629 |
|
60 |
Obesity Osama Hamdy
and Robert J. Smith |
630 |
|
61 |
Anorexia
Nervosa and Bulimia Nervosa Michelle P. Warren |
635 |
|
62 |
Malnutrition,
Nutritional Assessment, and Nutritional
Support in Adult Patients Thomas R. Ziegler |
638 |
|
63 |
Disorders
of Lipid Metabolism Geetha Gopalakrishnan
and Robert J. Smith |
643 |
|
64 |
Disorders
of Metals and Metalloproteins David G. Brooks |
651 |
|
SECTION XII |
ENDOCRINE DISEASE |
659 |
|
65 |
Hypothalamic-Pituitary
Axis Vivien S. Herman-Bonert |
660 |
|
66 |
Thyroid
Gland Vivien S. Herman-Bonert
and Theodore C. Friedman |
670 |
|
67 |
Adrenal
Gland Theodore C. Friedman |
679 |
|
68 |
Male
Reproductive Endocrinology Glenn
D. Braunstein |
691 |
|
69 |
Diabetes
Mellitus Philip S. Barnett and Glenn D. Braunstein |
697 |
|
70 |
Hypoglycemia Philip S. Barnett |
721 |
|
SECTION XIII |
WOMEN’S HEALTH |
729 |
|
71 |
Women’s
Health Topics Deborah Ehrenthal,
Patricia Carney, Renee Kottenhahn and Pamela Charney |
730 |
|
A |
Introduction |
730 |
|
B |
Preventive
Health Recommendations for Women |
733 |
|
C |
Health
Issues Across the Life Course |
734 |
|
D |
Special
Topics |
745 |
|
SECTION XIV |
MEN’S HEALTH |
751 |
|
72 |
Men’s
Health Topics Jonathan
S. Starkman,
Douglas F. Milam and Joseph A. Smith, Jr. |
752 |
|
A |
Benign Prostatic
Hyperplasia |
752 |
|
B |
Prostatitis |
757 |
|
C |
Erectile
Dysfunction |
759 |
|
D |
Carcinomas
of Men |
763 |
|
E |
Benign
Scrotal Diseases |
768 |
|
SECTION XV |
DISEASES OF BONE AND BONE MINERAL METABOLISM |
771 |
|
73 |
Normal
Physiology of Bone and Mineral Homeostasis Andrew F. Stewart |
772 |
|
74 |
Disorders
of Serum Minerals Steven P. Hodak and
Andrew F. Stewart |
783 |
|
75 |
Metabolic
Bone Diseases Shane O. LeBeau
and Andrew F. Stewart |
795 |
|
76 |
Osteoporosis Susan L. Greenspan |
802 |
|
77 |
Paget Disease of Bone Mara J. Horwitz and G. David Roodman |
811 |
|
SECTION XVI |
MUSCULOSKELETAL AND CONNECTIVE TISSUE DISEASE |
817 |
|
78 |
Approach to
the Patient with Rheumatic Disease Niveditha Mohan |
818 |
|
79 |
Rheumatoid
Arthritis Larry W. Moreland |
823 |
|
80 |
Spondyloarthropathies Douglas W. Lienesch |
829 |
|
81 |
Systemic
Lupus Erythematosus Jennifer
Rae Elliot |
834 |
|
82 |
Antiphospholipid Antibody Syndrome Surabhi Agarwal
and Amy H. Kao |
841 |
|
83 |
Systemic
Sclerosis (Scleroderma) Robyn T. Domsic
and Thomas A. Medsger,
Jr. |
844 |
|
84 |
Idiopathic
Inflammatory Myopathies Larry W. Moreland |
850 |
|
85 |
Sjögren Syndrome Fotios Koumpouras |
855 |
|
86 |
Systemic Vasculitis Kathleen Maksimowicz-Mckinnon |
858 |
|
87 |
Crystal Arthropathies Dana P. Ascherman |
864 |
|
88 |
Osteoarthritis C. Kent Kwoh |
870 |
|
89 |
Nonarticular Soft Tissue
Disorders Niveditha Mohan |
873 |
|
90 |
Rheumatic
Manifestations of Systemic Disorders Fotios Koumpouras |
878 |
|
SECTION XVII |
INFECTIOUS DISEASE |
883 |
|
91 |
Organisms
that Infect Humans Benigno Rodríguez
and Michael M. Lederman |
884 |
|
92 |
Host
Defenses Against Infection Benigno Rodriguez and Michael M. Lederman |
890 |
|
93 |
Laboratory
Diagnosis of Infectious Diseases Benigno Rodriguez and Michael M. Lederman |
898 |
|
94 |
Antimicrobial
Therapy Benigno Rodriguez and Michael M. Lederman |
904 |
|
95 |
Fever and
Febrile Syndromes Tracy L. Lemonovich
and Robert A. Salata |
910 |
|
96 |
Bacteremia and Sepsis
Syndrome Richard R. Watkins and Robert A. Salata |
925 |
|
97 |
Infections
of the Nervous System Scott A. Fulton and Robert A. Salata |
933 |
|
98 |
Infections
of the Head and Neck Christoph Lange and Michael M. Lederman |
945 |
|
99 |
Infections
of the Lower Respiratory Tract Christoph Lange and Michael M. Lederman |
951 |
|
100 |
Infections
of the Heart and Bloodvessels Benigno Rodriguez and Michael M. Lederman |
961 |
|
101 |
Skin and
Soft Tissue Infections Christoph Lange and Michael M. Lederman |
969 |
|
102 |
Intra-Abdominal
Abscess and Peritonitis Christoph Lange and Michael M. Lederman |
975 |
|
103 |
Infectious
Diarrhea Christoph Lange and Michael M. Lederman |
979 |
|
104 |
Infections
Involving Bones and Joints Christoph Lange and Michael M. Lederman |
985 |
|
105 |
Infections
of the Urinary Tract Christoph Lange and Michael M. Lederman |
989 |
|
106 |
Health
Care-Associated Infections Amy J. Ray, Michelle V. Lisgaris
and Robert A. Salata |
992 |
|
107 |
Sexually
Transmitted Infections Corrilynn O. Hileman, Keith B. Armitage
and Robert A. Salata |
998 |
|
108 |
Human
Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome Curt G. Beckwith, Edward J. Wing, Benigno
Rodriguez and Michael M. Lederman |
1008 |
|
109 |
Infections
in the Immunocompromised
Host Tracy Lemonovich,
David A. Bobak
and Robert A. Salata |
1028 |
|
110 |
Infectious
Diseases of Travelers: Protozoal
and Helminthic
Infections Jessica K. Fairley,
Keith B. Armitage
and Robert A. Salata |
1034 |
|
SECTION XVIII |
BIO TERRORISM |
1043 |
|
111 |
Bioterrorism Robert W. Bradsher,
Jr. |
1044 |
|
SECTION XIX |
NEUROLOGIC DISEASE |
1051 |
|
112 |
Neurologic Evaluation of the
Patient Frederick
J. Marshall |
1052 |
|
113 |
Disorders
of Consciousness Roger P. Simon |
1058 |
|
114 |
Disorders
of Sleep Lynn Liu |
1064 |
|
115 |
Cortical
Syndromes Sinéad M. Murphy and Timothy J.
Counihan |
1068 |
|
116 |
Dementia
and Memory Disturbances Frederick
J. Marshall |
1072 |
|
117 |
Major
Disorders of Mood, Thoughts, and Behavior Jeffrey M. Lyness |
1077 |
|
118 |
Disorders
of Thermal Regulation William P. Cheshire, Jr. |
1083 |
|
119 |
Headache,
Neck Pain, and Other Painful Disorders Timothy J. Counihan |
1086 |
|
120 |
Disorders
of Vision and Hearing Allan McCarthy
and Timothy J. Counihan |
1096 |
|
121 |
Dizziness
and Vertigo Kevin A. Kerber |
1104 |
|
122 |
Disorders
of the Motor System Frederick
J. Marshall |
1108 |
|
123 |
Developmental
and Neurocutaneous
Disorders Emily C. de los
Reyes and E. Steve Roach |
1119 |
|
124 |
Cerebrovascular Disease Sinead M. Murphy and Timothy J. Counihan |
1123 |
|
125 |
Traumatic
Brain Injury and Spinal Cord Injury Geoffrey S.F. Ling |
1136 |
|
126 |
Epilepsy Michel J. Berg |
1141 |
|
127 |
Central
Nervous System Tumors Lisa R.
Rogers and Jennifer J. Griggs |
1154 |
|
128 |
Infectious
Diseases of the Nervous System Avindra Nath |
1159 |
|
129 |
Demyelinating and Inflammatory
Disorders Deborah
Joanne Lynn |
1165 |
|
130 |
Neuromuscular
Diseases: Disorders of the Motor Neuron and Plexus and Peripheral Nerve
Disease Carlayne E. Jackson |
1171 |
|
131 |
Muscle
Diseases Robert C. Griggs |
1182 |
|
132 |
Neuromuscular
Junction Disease Emma Ciafaloni |
1191 |
|
SECTION XX |
THE AGING PATIENT |
1195 |
|
133 |
The Aging
Patient Mitchell T. Heflin and Harvey Jay Cohen |
1196 |
|
SECTION XXI |
PALLIATIVE CARE |
1209 |
|
134 |
Palliative
Care Robert G. Holloway and Timothy E. Quill |
1210 |
|
SECTION XXII |
ALCOHOL AND SUBSTANCE ABUSE |
1219 |
|
135 |
Alcohol and
Substance Abuse Richard A. Lange and L. David Hillis |
1220 |
|
|
Index |
1235 |
|
|
|
|