Table of Contents

 

 

 

SECTION I

NORMAL STRUCTURE AND FUNCTION

 

Chapter 1

Embryology of the Kidney   Yoshiro Maezawa, Jordan Kreidberg, and Susan E. Quaggin

2

Chapter 2

Anatomy of the Kidney   Søren Nielson, Tae-Hwan Kwon, Robert A. Fenton, and Jeppe Prætorious

31

Chapter 3

The Renal Circulations and Glomerular Ultrafiltration   Karen A. Munger, Curtis K. Kost Jr., Barry M. Brenner, and David A. Maddox

94

Chapter 4

Metabolic Basis of Solute Transport   Alicia A. McDonough and Scott C. Thomson

138

Chapter 5

Transport of Sodium, Chloride, and Potassium   David B. Mount

158

Chapter 6

Aldosterone Regulation of Ion Transport   David Pearce, Vivek Bhalla, John W. Funder, and John B. Stokes

202

Chapter 7

Transport of Calcium, Magnesium, and Phosphate   René J.M. Bindels, Joost G.J. Hoenderop, and Jürg Biber

226

Chapter 8

Renal Handling of Organic Solutes   Orson W. Moe, Stephen H. Wright, and Manuel Palacín

252

Chapter 9

Renal Acidification Mechanisms   I. David Weiner and Jill W. Verlander

293

Chapter 10

Urine Concentration and Dilution   Jeff M. Sands, Harold E. Layton, and Robert A. Fenton

326

Chapter 11

The Cell Biology of Vasopressin Action   Dennis Brown and Robert A. Fenton

353

Chapter 12

Vasoactive Molecules and the Kidney   Richard E. Gilbert, David S. Game, and Andrew Advani

384

Chapter 13

Arachidonic Acid Metabolites and the Kidney   Raymond C. Harris, Matthew D. Breyer, and Richard M. Breyer

421

SECTION II

DISORDERS OF BODY FLUID VOLUME AND COMPOSITION

 

Chapter 14

Disorders of Sodium Balance   Itzchak N. Slotki and Karl L. Skorecki

464

Chapter 15

Disorders of Water Balance   Joseph G. Verbalis

540

Chapter 16

Disorders of Acid-Base Balance   Thomas D. DuBoseJr.

595

Chapter 17

Disorders of Potassium Balance   David B. Mount and Kambiz Zandi-Nejad

640

Chapter 18

Disorders of Calcium, Magnesium, and Phosphate Balance   Miroslaw J. Smogorzewski, Robert K. Rude, and Alan S.L. Yu

689

SECTION III

EPIDEMIOLOGY AND RISK FACTORS IN KIDNEY DISEASE

 

Chapter 19

Epidemiology of Kidney Disease   Chi-yuan Hsu

728

Chapter 20

Demographics of Kidney Disease   Amanda Hyre Anderson, Jeffrey S. Berns, Melissa B. Bleicher, and Harold I. Feldman

742

Chapter 21

Risk Factors and Chronic Kidney Disease   Maarten W. Taal

758

Chapter 22

Nephron Endowment   Valerie A. Luyckx and Barry M. Brenner

782

Chapter 23

Aging and Kidney Disease   Devasmita Choudhury, Moshe Levi, and Meryem Tuncel

809

SECTION IV

EVALUATION OF THE PATIENT WITH KIDNEY DISEASE

 

Chapter 24

Approach to the Patient with Kidney Disease   Michael Emmett, Andrew Z. Fenves, and John C. Schwartz

844

Chapter 25

Laboratory Assessment of Kidney Disease: Glomerular Filtration Rate, Urinalysis, and Proteinuria   Ajay K. Israni and Bertram L. Kasiske

868

Chapter 26

Interpretation of Electrolyte and Acid-Base Parameters in Blood and Urine   Kamel S. Kamel, Mogamat Razeen Davids, Shih-Hua Lin, and Mitchell L. Halperin

897

Chapter 27

Diagnostic Kidney Imaging   William D. Boswell,Jr., Hossein Jadvar, and Suzanne L. Palmer

930

Chapter 28

The Renal Biopsy   Alan D. Salama and H. Terence Cook

1006

Chapter 29

Biomarkers in Acute and Chronic Kidney Diseases   Venkata Sabbisetti and Joseph V. Bonventre

1016

SECTION V

DISORDERS OF KIDNEY STRUCTURE AND FUNCTION

 

Chapter 30

Acute Kidney Injury   Asif Sharfuddin, Steven D. Weisbord, Paul M. Palevsky, and Bruce A. Molitoris

1044

Chapter 31

Primary Glomerular Disease   Patrick H. Nachman, J. Charles Jennette, and Ronald J. Falk

1100

Chapter 32

Secondary Glomerular Disease   Gerald B. Appel, Jai Radhakrishnan, and Vivette D. D’Agati

1192

Chapter 33

Overview of Therapy for Glomerular Disease   Daniel C. Cattran and Heather N. Reich

1278

Chapter 34

Microvascular and Macrovascular Diseases of the Kidney   Piero Ruggenenti, Paolo Cravedi, and Giuseppe Remuzzi

1297

Chapter 35

Tubulointerstitial Diseases   Carolyn J. Kelly and Eric G. Neilson

1332

Chapter 36

Urinary Tract Infection in Adults   Lindsay E. Nicolle

1356

Chapter 37

Urinary Tract Obstruction   Jørgen Frøkiaer and Mark L. Zeidel

1383

Chapter 38

Diabetic Nephropathy   Hans-Henrik Parving, Michael Mauer, Paola Fioretto, Peter Rossing, and Eberhard Ritz

1411

Chapter 39

Nephrolithiasis   David A. Bushinsky, Fredric L. Coe, and Orson W. Moe

1455

Chapter 40

Renal Neoplasia   Scott E. Delacroix Jr., Christopher G. Wood, and Eric Jonasch

1508

Chapter 41

Renal Disease in Cancer Patients   Kevin W. Finkel, Amit Lahoti, and John R. Foringer

1536

SECTION VI

GENETICS OF KIDNEY DISEASE

 

Chapter 42

Genetic Basis of Kidney Disease   Barry I. Freedmarty Donald W. Bowden, and Stephen S. Rich

1554

Chapter 43

Inherited Disorders of the Glomerulus   Karl Tryggvason and Jaakko Patrakka

1570

Chapter 44

Inherited Disorders of the Renal Tubule   Alain Bonnardeaux and Daniel G. Bichet

1584

Chapter 45

Cystic Diseases of the Kidney   Vicente E. Torres and Jared J. Grantham

1626

SECTION VII

HYPERTENSION AND THE KIDNEY

 

Chapter 46

Primary and Secondary Hypertension   Jon D. Blumenfeld, Frank Liu, and John H. Laragh

1670

Chapter 47

Renovascular Hypertension and Ischemic Nephropapthy   Stephen C. Textor

1752

Chapter 48

Hypertension and Kidney Disease in Pregnancy   Sharon E. Maynard, S. Ananth Karumanchi, and Ravi Thadhani

1792

Chapter 49

Antihypertensive Drugs   Matthew R. Weir, Donna S. Hanes, and David K. Klassen

1824

Chapter 50

Diuretics   David H. Ellison, Ewout J. Hoorn, and Christopher S. Wilcox

1879

SECTION VIII

THE CONSEQUENCES OF ADVANCED KIDNEY DISEASE

 

Chapter 51

Adaptation to Nephron Loss and Mechanisms of Progression in Chronic Kidney Disease   Maarten W. Taal and Barry M. Brenner

1918

Chapter 52

Mechanisms and Consequences of Proteinuria   Norberto Perico, Andrea Remuzzi, and Giuseppe Remuzzi

1972

Chapter 53

The Pathophysiology Of Uremia   Timothy W. Meyer and Thomas H. Hostetter

2000

Chapter 54

Chronic Kidney Disease-Mineral Bone Disorder   Sharon M. Moe and Stuart M. Sprague

2021

Chapter 55

Cardiovascular Aspects of Kidney Disease   David C. Wheeler, Richard Haynes, Martin J. Landray, and Colin Baigent

2059

Chapter 56

Hematologic Aspects of Kidney Disease   Carlo Brugnara and Kai-Uwe Eckardt

2081

Chapter 57

Endocrine Aspects of Chronic Kidney Disease   Juan Jesús Carrero, Peter Stenvinkel, and Bengt Lindholm

2122

Chapter 58

Neurologic Aspects of Kidney Disease   Manjula Kurella Tamura

2138

Chapter 59

Dermatologic Conditions in Kidney Disease   Christine J. Ko and Shawn E. Cowper

2156

SECTION IX

CONSERVATIVE MANAGEMENT OF KIDNEY DISEASE

 

Chapter 60

Dietary Approaches to Kidney Diseases   Denis Fouque and William E. Mitch

2170

Chapter 61

A Stepped Care Approach to the Management of Chronic Kidney Disease   Damian G. Fogarty and Maarten W. Taal

2205

Chapter 62

Vitamin D, Calcimimetic Agents, and Phosphate Binders   L. Darryl Quarles

2240

Chapter 63

Prescribing Drugs in Kidney Disease   Christopher W. McIntyre, Susan Shaw, and Mohamed T. Eldehni

2258

SECTION X

DIALYSIS AND EXTRACORPOREAL THERAPIES

 

Chapter 64

Hemodialysis   Jane Y, Yeun, Daniel Ornt, and Thomas A. Depner

2294

Chapter 65

Peritoneal Dialysis   Richardo Correa-Rotter, Alfonso Cueto-Manzano, and Ramesh Khanna

2347

Chapter 66

Critical Care Nephrology   John A. Kellum, Rinaldo Bellomo, and Claudio Ronco

2378

Chapter 67

Plasmapheresis   Ernesto Sabath and Bradley M. Denker

2394

Chapter 68

Extracorporeal Treatment of Poisoning   James P. Smith and Ingrid J. Chang

2411

Chapter 69

Interventional Nephrology   Ivan D. Maya and Michael Allon

2432

SECTION XI

KIDNEY TRANSPLANTATION

 

Chapter 70

Transplantation Immunobiology   Mohamed H. Sayegh and Anil Chandraker

2468

Chapter 71

Donor and Recipient Issues   Hassan N. Ibrahim, Bertram L. Kasiske, and Arthur J. Matas

2495

Chapter 72

Clinical Management   Jane C. Tan, Stéphan Busque, and John D. Scandling

2515

SECTION XII

PEDIATRIC NEPHROLOGY

 

Chapter 73

Malformation of the Kidney: Structural and Functional Consequences   Norman D. Rosenblum

2258

Chapter 74

Fluid, Electrolyte, and Acid-Base Disorders in Children   James C. Chan, Fernando Santos, and Matthew Hand

2572

Chapter 75

Diseases of the Kidney and Urinary Tract in Children   Sevcan A. Bakkaloglu and Franz Schaefer

2622

Chapter 76

Dialysis in Children   Timothy E. Bunchman and Gina-Marie Barletta

2680

Chapter 77

Pediatric Transplantation   Jon I. Scheinman

2694

SECTION XIII

GLOBAL CONSIDERATIONS IN KIDNEY DISEASE

 

Chapter 78

Latin America   Miguel C. Riella and Roberto Pecoits-Filho

2720

Chapter 79

Africa   Saraladevi Naicker and Shoyab Wadee

2733

Chapter 80

Near and Middle East   Suheir Assady, Rawi Ramadan, and Dvora Rubinger

2744

Chapter 81

Indian Subcontinent   Vinay Sakhuja and Harbir Singh Kohli

2770

Chapter 82

Far East   Visith Sitprija, Kriang Tungsanga, and Kearkiat Praditpornsilpa

2786

Chapter 83

Renal Disease in the Oceania Region   Gavin J. Becker, John F. Collins, and David C.H. Harris

2803

SECTION XIV

CHALLENGES IN NEPHROLOGY

 

Chapter 84

Ethical Dilemmas Facing Nephrology: Past, Present, and Future   Alvin H. Moss

2822

Chapter 85

Health Disparities in Nephrology   Neil R. Powe and Carmen A. Peralta

2836

Chapter 86

Tissue Engineering, Stem Cells, and Cell Therapy in Nephrology   L. Spencer Krane and Anthony Atala

2851

 

Index

I1-I69