Table of Contents

 

 

 

SECTION 1

BASIC CONCEPTS

 

1

Introduction to the Study of Rheumatic Diseases in Children   James T. Cassidy and Ross E. Petty

1

2

Structure and Function   Ross E. Petty and James T. Cassidy

6

3

Immunology and Rheumatic Diseases   Marco Gattorno and Alberto Martini

16

4

Inflammation   Berent J. Prakken and Salvatore Albani

53

5

Integrative Genomics   Robert A. Colbert, Susan D. Thompson and David N. Glass

60

6

Pharmacology and Drug Therapy   Norman T. Ilowite and Ronald M. Laxer

71

7

Trial Design, Measurement, and Analysis of Clinical Investigations   Hermine I. Brunner and Edward H. Giannini

127

8

Assessment of Health Status, Function, and Quality of Life Outcomes   Ciarán M. Duffy and Brian M. Feldman

157

9

Managing Children with Rheumatic Diseases   Balu H. Athreya and Carol B. Lindsley

168

10

Radiologic Investigation of Pediatric Rheumatic Diseases   Paul Babyn and Andrea Schwarz Doria

177

11

Pain   Michael A. Rapoff and Carol B. Lindsley

192

12

Occupational and Physical Therapy for Childhood Rheumatic Diseases   Gay Kuchta and Iris Davidson

198

SECTION 2

CHRONIC ARTHRITIS

 

13

Chronic Arthritis in Childhood   Ross E. Petty and James T. Cassidy

211

14

Systemic Juvenile Idiopathic Arthritis   Fabrizio de Benedetti and Rayfel Schneider

236

15

Polyarthritis   Alan M. Rosenberg and Kiem G. Oen

249

16

Oligoarthritis   Ross E. Petty and James T. Cassidy

262

17

Enthesitis-Related Arthritis (Juvenile Ankylosing Spondylitis)   Ross E. Petty and James T. Cassidy

272

18

Juvenile Psoriatic Arthritis   Peter A. Nigrovic, Robert P. Sundel, and Ross E. Petty

287

19

Arthropathies of Inflammatory Bowel Disease   Carol B. Lindsley and Ronald M. Laxer

298

20

Uveitis in Juvenile Idiopathic Arthritis   Ross E. Petty and James T. Rosenbaum

305

SECTION 3

SYSTEMIC CONNECTIVE TISSUE DISEASES

 

21

Systemic Lupus Erythematosus   Earl Silverman and Allison Eddy

315

22

Antiphospholipid Syndrome   Tadej Avčin and Kathleen M. O’Neil

344

23

Neonatal Lupus Erythematosus   Jill P. Buyon, Carol B. Lindsley and Earl D. Silverman

361

24

Juvenile Dermatomyositis   Lisa G. Rider, Carol B. Lindsley and James T. Cassidy

375

25

The Systemic Sclerodermas and Related Disorders   Francesco Zulian and James T. Cassidy

414

26

Localized Sclerodermas   Francesco Zulian and Ronald M. Laxer

438

27

Mixed Connective Tissue Disease and Undifferentiated Connective Tissue Disease   Peri H. Pepmueller, Carol B. Lindsley, and James T. Cassidy

448

28

Sjögren Syndrome   Lori B. Tucker

458

29

Raynaud Phenomenon and Vasomotor Syndromes   Robert C. Fuhlbrigge

466

SECTION 4

SYSTEMIC VASCULITIS

 

30

Vasculitis and its Classification   James T. Cassidy and Ross E. Petty

479

31

Leukocytoclastic Vasculitis   Paul Brogan and Arvind Bagga

483

32

Polyarteritis Nodosa and Cutaneous Polyarteritis Nodosa   Michael J. Dillon and Seza Ozen

498

33

Kawasaki Disease   Robert P. Sundel and Ross E. Petty

505

34

Granulomatous Vasculitis, Microscopic Polyanghtis and Primary Angiitis of the Central Nervous System   David Cabral and Susanne Benseler

521

35

Pediatric Sarcoidosis   Carlos D. Rose and Carine H. Wouters

544

36

Behçet Disease   Seza Ozen and Ross E. Petty

552

SECTION 5

ARTHRITIS RELATED TO INFECTION

 

37

Infectious Arthritis and Osteomyelitis   Ronald M. Laxerand Carol B. Lindsley

559

38

Lyme Disease   Hans-Iko Huppertz and Frank Dressier

579

39

Reactive Arthritis   Rubén Burgos-Vargas and Janitzia Vázquez-Mellado

591

40

Acute Rheumatic Fever and Post-Streptococcal Reactive Arthritis   Khaled Alsaeid and James T. Cassidy

600

SECTION 6

SYSTEMIC DISORDERS WITH RHEUMATIC MANIFESTATIONS

 

41

Musculoskeletal Manifestations of Systemic Disease   James T. Cassidy and Ross E. Petty

615

42

Immunodeficiencies and the Rheumatic Diseases   Nico M. Wulffraat, Joris Van Montfrans, and Wietse Kuis

627

43

Periodic Fever Syndromes and Other Inherited Autoinflammatory Diseases   Karyl Barron, Balu Athreya, and Daniel Kastner

642

44

Autoinflammatory Bone Disorders   Polly J. Ferguson and Ronald M. Laxer

661

45

Macrophage Activation Syndrome   Alexei A. Grom

674

46

Skeletal Malignancies and Related Disorders   James T. Cassidy and Ross E. Petty

682

SECTION 7

NONINFLAMMATORY CAUSES OF MUSCULOSKELETAL PAIN

 

47

Noninflammatory Musculoskeletal Pain Conditions   Claire LeBlanc and Kristin Houghton

697

48

Pain Amplification Syndromes   David D. Sherry

718

49

Skeletal Maturation and Bone Mineralization in the Pediatric Rheumatic Diseases   Rolando Cimaz and Fernanda Falcini

730

50

Primary Disorders of Bone and Connective Tissues   Deborah Wenkert

742

 

Index

767