Table of Contents

 

 

 

Chapter 1

Glomerular Diseases

1

 

Normal Growth and Maturation

2

 

Primary Glomerular Diseases

11

 

Glomerular Diseases that Cause Nephrotic Syndrome: Non-Immune Complex

11

 

Minimal Change Disease and Focal Segmental Glomerulosclerosis: Introduction

11

 

Minimal Change Disease

12

 

Focal Segmental Glomerulosclerosis

16

 

Collapsing Glomerulopathy

28

 

Tip Lesion Variant of FSGS

35

 

Cellular Variant of FSGS

37

 

Perihilar Variant of FSGS

39

 

Congenital Nephrotic Syndrome of Finnish Type

42

 

Diffuse Mesangial Sclerosis

45

 

Glomerular Diseases that Cause Nephrotic/Nephritic Syndrome: Complement Related

50

 

C1q Nephropathy

50

 

Dense Deposit Disease

53

 

C3 Glomerulonephritis

61

 

Glomerular Diseases that Cause Nephrotic Syndrome: Immune Complex

65

 

Membranous Nephropathy

65

 

Membranoproliferative Glomerulonephritis, Type 1

80

 

Fibrillary Glomerulonephritis

94

 

Immunotactoid Glomerulopathy

102

 

Glomerular Diseases that Cause Hematuria or Nephritic Syndrome: Immune Complex

107

 

Acute Postinfectious Glomerulonephritis

107

 

IgA Nephropathy

118

 

Secondary Glomerular Diseases

132

 

Diseases Associated with Nephrotic Syndrome

132

 

Monoclonal Immunoglobulin Deposition Disease

132

 

Amyloidosis

133

 

Proliferative Glomerulonephritis with Monoclonal Deposits

159

 

HIV-Associated Nephropathy

163

 

Sickle Cell Nephropathy

170

 

Fabry Disease

177

 

Lipoprotein Glomerulopathy

183

 

Lecithin-Cholesterol Acyltransferase Deficiency

185

 

Hereditary Focal Segmental Glomerulosclerosis

189

 

Diseases Associated with Nephritic Syndrome or RPGN: Immune Mediated

190

 

Lupus Nephritis

190

 

Atypical Presentations of Renal Involvement in SLE

212

 

Henoch-Schönlein Purpura

223

 

Mixed Connective Tissue Disease

233

 

Mixed Cryoglobulinemia

241

 

Anti-GBM Antibody-Mediated Glomerulonephritis

252

 

Diseases Associated with the Nephritic Syndrome or RPGN: Pauci-Lmmune- or Non-Immune-Mediated

260

 

Introduction

260

 

Granulomatosis with Polyangiitis (Wegener)/Microscopic Polyangiitis

262

 

Polyarteritis Nodosa

271

 

Churg-Strauss Syndrome

272

 

Diseases of the Basement Membrane

273

 

Alport Syndrome

273

 

Thin Basement Membrane Lesions

283

 

Nail-Patella Syndrome

286

 

Glomerular Involvement with Bacterial Infections

288

 

Subacute Bacterial Endocarditis

288

 

Shunt Nephritis

294

Chapter 2

Vascular Diseases

303

 

Diabetic Nephropathy

303

 

Thrombotic Microangiopathy/Thrombotic Thrombocytopenic Purpura

315

 

Scleroderma (Progressive Systemic Sclerosis)

330

 

Antiphospholipid Antibody Disease

338

 

Preeclampsia and Eclampsia

338

 

Fibromuscular Dysplasia

348

 

Arterionephrosclerosis

353

 

Accelerated/Malignant Hypertension

364

 

Atheroemboli

369

Chapter 3

Tubulointerstitial Diseases

377

 

Introduction

377

 

Acute Pyelonephritis

379

 

Chronic Pyelonephritis and Reflux Nephropathy

385

 

Xanthogranulomatous Pyelonephritis

388

 

Malakoplakia

390

 

Acute Tubulointerstitial Nephritis—Drug-Related

391

 

Acute Tubulointerstitial Nephritis—Viral Infection

399

 

Anti-TBM Antibody Nephritis

400

 

IgG4-Related Tubulointerstitial Nephritis

403

 

Sarcoidosis

409

 

Acute Kidney Injury/Acute Tubular Necrosis

414

 

Heavy Metal Nephropathy (Lead and Cadmium Nephropathy)

434

 

Analgesic Nephropathy and Papillary Necrosis

435

 

Light Chain Cast Nephropathy and Tubulopathy

438

 

Tubular Crystallopathies

449

 

Nephrocalcinosis

454

 

Indinavir Nephropathy

462

 

Lithium Nephropathy

463

 

Aristolochic Acid Nephropathy

464

Chapter 4

Chronic Kidney Disease

465

 

Introduction

465

 

Age-Related Sclerosis

465

 

Glomerular vs. Tubulointerstitial vs. Vascular Disease

469

 

Segmental Glomerulosclerosis: Primary vs. Secondary

470

Chapter 5

Renal Transplantation

473

 

Introduction

473

 

Antibody-Mediated Rejection

475

 

Chronic Active Antibody-Mediated Rejection and Transplant Glomerulopathy

478

 

Acute T Cell-Mediated Rejection

479

 

Chronic Allograft Failure (Chronic Allograft Nephropathy)

485

 

Cyclosporin/FK506 Nephrotoxicity

486

 

Posttransplant Lymphoproliferative Disease

488

 

Viral Infections

491

Chapter 6

Cystic Diseases of the Kidney

499

 

Introduction

499

 

Autosomal Dominant Polycystic Kidney Disease

499

 

Autosomal Recessive Polycystic Kidney Disease

504

 

Medullary Cystic Disease/Nephronophthisis

506

 

Medullary Sponge Kidney

508

 

Acquired Cystic Disease

511

 

Cystic Renal Dysplasia

513

Chapter 7

Renal Neoplasia

517

 

Introduction

517

 

Renal Cell Carcinomas

517

 

Other Renal Epithelial Tumors

519

 

Wilms Tumor

529

 

Transitional Cell Carcinoma of the Renal Pelvis

533