SECTION A

PLACENTA AND FETAL WATER FLUX

Chapter 1

Water Flux and Amniotic Fluid Volume: Understanding Fetal Water Flow   Marie H. Beall, MD, Jeroen P.H.M. van den Wijngaard, PhD, Martin van Gemert, PhD, Michael G. Ross, MD, MPH

3

Chapter 2

Body Water Changes in the Fetus and Newborn: Normal Transition After Birth and the Effects of Intrauterine Growth Aberration   William Oh, MD

19

SECTION B

ELECTROLYTE BALANCE DURING NORMAL FETAL AND NEONATAL DEVELOPMENT

Chapter 3

Renal Aspects of Sodium Metabolism in the Fetus and Neonate   Endre Sulyok, MD, PhD, DSc

31

Chapter 4

Potassium Metabolism   John M. Lorenz, MD

61

Chapter 5

Renal Urate Metabolism in the Fetus and Newborn   Daniel I. Feig, MD, PhD

75

Chapter 6

Perinatal Calcium and Phosphorus Metabolism   Ran Namgung, MD, PhD, Reginald C. Tsang, MBBS

85

Chapter 7

Acid-Base Homeostasis in the Fetus and Newborn   Istvan Seri, MD, PhD

105

SECTION C

THE KIDNEY: NORMAL DEVELOPMENT AND HORMONAL CONTROL

Chapter 8

Glomerular Filtration Rate in Neonates   Jean-Pierre Guignard, MD, Jean-Bernard Gouyon, MD

117

SECTION D

SPECIAL PROBLEMS

Chapter 9

The Developing Kidney and the Fetal Origins of Adult Cardiovascular Disease   Farid Boubred, MD, Christophe Buffat, PharmD, Daniel Vaiman, PhD, Umberto Simeoni, MD

139

Chapter 10

Renal Modulation: The Renin-Angiotensin-Aldosterone System   Aruna Natarajan, MD, DCh, PhD, Pedro A. Jose, MD, PhD

155

Chapter 11

Renal Modulation: Arginine Vasopressin and Atrial Natriuretic Peptide   Marco Zaffanello, MD, Andrea Dotta, MD, Francesco Emma, MD

179

Chapter 12

Acute Problems of Prematurity: Balancing Fluid Volume and Electrolyte Replacements in Very Low Birth Weight and Extremely Low Birth Weight Neonates   Stephen Baumgart, MD

199

Chapter 13

Lung Fluid Balance in Developing Lungs and Its Role in Neonatal! Transition   Sarah D. Keene, MD, Richard D. Bland, MD, Lucky Jain, MD, MBA

211

Chapter 14

Use of Diuretics in the Newborn   Jean-Pierre Guignard, MD

233

Chapter 15

Neonatal Hypertension: Diagnosis and Management   Joseph T. Flynn, MD, MS

251

Chapter 16

Edema   Yosef Levenbrown, DO, Andrew T. Costarino, MD

267

Chapter 17

Kidney Injury in the Neonate   Sharon P. Andreoli, MD

285

Chapter 18

Hereditary Tubulopathies   Israel Zelikovic, MD

305

Chapter 19

Obstructive Uropathy: Assessment of Renal Function in the Fetus   Robert L Chevalier, MD

335