Chapter 1

Introduction Jeffrey M. Perlman, MB, ChB

1

Chapter 2

Cerebral Circulation and Hypotension in the Premature Infant: Diagnosis and Treatment Claire W. McLean, MD, Shahab Noori, MD, Rowena G. Cayabyab, MD, and Istvan Seri, MD, PhD

3

Chapter 3

Intraventricular Hemorrhage and White Matter Injury in the Preterm Infant Toshiki Takenouchi, MD, and Jeffrey M. Perlrnan, MB, ChB

27

Chapter 4

Posthemorrhagic Hydrocephatus Management Strategies Andrew Whitelaw, MD, FRCPCH

47

Chapter 5

The Use of Hypothermia to Provide Neuroprotection for Neonatal Hypoxic-lschemic Brain Injury Abbot R. Laptook, MD

63

Chapter 6

General Supportive Management of the Term Infant with Neonatal Encephalopathy Following Intrapartum Hypoxia-lschemia Ericalyn Kasdorf, MD, and Jeffrey M. Perlman, MB, ChB

77

Chapter 7

Perinatal Stroke Eliza H. Myers, MD, and Laura R. Ment, MD

91

Chapter 8

Diagnosis and Treatment of Neonatal Seizures Mark S. Scher, MD

109

Chapter 9

Glucose and Perinatal Brain Injury: Questions and Controversies Jerome Y. Yager, MD

143

Chapter 10

Hyperbilirubinemia and the Risk for Brain Injury Steven M. Shapiro, MD, MSHA

163

Chapter 11

Neonatal Meningitis: Current Treatment Options David Kaufman, MD, Santina Zanelli, MD, Joseph B. Cantey, MD, and Pablo J. Sánchez, MD

181

Chapter 12

Neonatal Herpes Simplex Virus and Congenital Cytomegalovirus Infections David W. Kimberlin, MD

203

Chapter 13

Pain and Stress: Potential Impact on the Developing Brain Lisa Eiland, MD

219

Chapter 14

Neonatal Hypotonia and Neuromuscular Disorders Jahannaz Dastgir, DO, Keung-kit Chan, MBBS, MRCPCH, and Basil T. Darras, MD

237

Chapter 15

Amplitude Integrated EEG and Its Potential Role in Augmenting Management within the NICU Mona C. Toet, MD, PhD, and Linda S. de Vries, MD, PhD

263

Chapter 16

Magnetic Resonance Imaging’s Role in the Care of the Infant at Risk for Brain Injury Gregory A. Lodygensky, MD, Caroline C. Menache, MD, and Petra S. Hüppi, MD

285

Chapter 17

Long-Term Follow-Up of Very Low-Birth-Weight Infants Betty R. Vohr, MD

325