1

Quality Management and Regulation   Jeffrey Prichard

1

2

Technique and Troubleshooting of Antibody Testing   Fan Lin and Jianhui Shi

17

3

Overview of Automated Immunohistochemistry   Jeffrey Prichard, Angela Bitting, and Joe Myers

23

4

Automated Staining: Dako Perspective   Ole F. Rasmussen and Andreas Schønau

31

5

Automated Staining: Ventana Perspective   Angela Sattler

37

6

Tissue Microarray   Myra Wilkerson and Erin Powell

45

7

Unknown Primary/Undifferentiated Neosplasms in Surgical and Cytologic Specimens   Fan Lin and Haiyan Liu

55

8

Exfoliative Cytopathology   Steven Meschter and Jan F. SiLverman

85

9

Predictive Markers of Breast Cancer: ER, PR, and HER2   Jeffrey Prichard, David Hicks, and Elizabeth Hammond

103

10

Central and Peripheral Nerve System Tumors   Hueizhi (Hope) Wu, Conrad Schuerch, and Douglas C. Miller

119

11

Thyroid and Parathyroid Gland   Haiyan Liu, Fan Lin, and Ronald A. DeLellis

137

12

Adrenal Gland   Hanna G. Kaspar

159

13

Salivary Gland and Other Head and Neck Structures   Conrad Schuerch

173

14

Lung, Pleura, and Mediastinum   Kai Zhang and Phillip Cagle

197

15

Breast   Haiyan Liu

225

16

Uterus   Hanna G. Kaspar

249

17

Ovary   Jeffrey Prichard, Haiyan Liu, and Myra Wilkerson

277

18

Prostate Gland   Haiyan Liu, Fan Lin, and Qihui (Jim) Zhai

299

19

Urinary Bladder   Myra Wilkerson

321

20

Kidney   Fan Lin and Ximing J. Yang

335

21

Testis and Paratesticular Tissues   Myra Wilkerson

355

22

Pancreas and Ampulla   Fan Lin and Hanlin L. Wang

367

23

Liver, Bile Ducts, and Gallbladder   Jeffrey Prichard and Fan Lin

389

24

Upper Gastrointestinal Tract   Jinhong Li and Fan Lin

409

25

Lower Gastrointestinal Tract and Microsatellite Instability   Jinhong Li and Fan Lin

423

26

Soft Tissue and Bone Tumors   Shaobo Zhu and Markku Miettinen

435

27

Lymph Node   Xiaohong (Mary) Zhang and Nadine S. Aguilera

461

28

Bone Marrow   R. Patrick Dorion and Xiaohong (Mary) Zhang

493

29

Infectious Diseases   Dirk M. Elston, Lawrence E. Gibson, and Heinz Kutzner

501

30

Skin   Tammie Ferringer

521

31

Application of Direct Immunofluorescence for Skin and Mucosal Biopsies: A Practical Review   William B. Tyler

543

32

In Situ Hybridization in Surgical and Cytologic Specimens   Hong Yin and Barbara Paynton

563

Appendix A

585

Appendix B

595

Index

605