Table
of Contents
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Primary prevention of
genetic disorders and place of preimplantation diagnosis |
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Approaches to
preimplantation diagnosis |
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Obtaining Biopsy
Material |
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Polar Body Diagnosis |
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Pre-embryonic Genetic
Diagnosis (PEGD) |
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Preconception Testing
for Paternally Derived Mutations by Sperm Duplication |
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Development of
artificial human gametes in vitro |
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Embryo Biopsy |
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Single cell genetic
analysis |
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DNA Analysis |
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FISH Analysis |
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Microarray analysis |
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Preimplation diagnosis
for single gene disorders |
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Autosomal Recessive
Diseases |
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Autosomal Dominant
Disorders |
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X-linked disorders |
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Homozygous or Double
Heterozygous Recessive Conditions |
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Conditions with No
Available Direct Mutation Testing |
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De Novo Mutations |
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Late-onset disorders
with genetic predisposition |
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Inherited
Predisposition to Cancer |
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Alzheimer Disease |
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Inherited Cardiac
Diseases |
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Blood Group
Incompatibility |
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Congenital
Malformations |
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Currarino Triad |
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Dynamic Mutations |
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Overall Experience of
PGD for Mendelian Disorders |
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PGD for HLA typing |
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Fanconi Anemia |
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World’s First PGD for
HLA Typing |
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Thalassemia |
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Immunodeficiencies |
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Preimplantation HLA
Matching without PGD |
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Limitations and future
prospect of PGD for HLA Typing |
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Practical Implications
of PGD for HLA Typing |
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Preimplantation
diagnosis for chromosomal disorders |
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First Polar Body
Morphological Grading as Possible Potential Means for Preselecting Viable
Oocytes |
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Aneuploidy in human
oocytes |
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Testing for both
meiosis I and meiosis II errors required for PGD of aneuploidies |
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Inconsistency between
Aneuploidy Types Predicted by PB1 and Detected by Cleavage Stage Testing |
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Complex Errors and
Aneuloidy Rescue in Female Meiosis |
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Chromosome Specific
Meiotic Error Origin and Its Impact on Embryo Viability |
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Mitotic Errors in
Cleaving Embryos in Relation to Meiosis Errors |
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PCR-based aneuploidy
testing in cleaving embryos |
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Practical Relevance of
Autosomal Monosomy Detection |
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Uniparental Disomies |
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Impact of PB Testing in
Detection and Avoidance of Aneuploid Embryos for Transfer |
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Chromosomal
rearrangements |
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Polar Boby Approach |
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Blastomere Nuclear
Conversion by Fusion with Mouse Oocytes |
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Chemical Conversion
Method |
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Clinical outcome of
preimplantation genetic diagnosis |
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Safety of PGD |
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Diagnostic Accuracy of
PGD |
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Reproductive outcome of
PGD |
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Controversy in
Assessing Clinical Outcome of Preimplantation Aneuploidy Testing |
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Reproductive Outcome
Before and after PGD in Same Couples |
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Possible Impact of
Aneuploidy Origin |
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Possible Impact of 24
Chromosome Aneuploidy Testing |
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Preimplantation
diagnosis and establishment of disease and individual specific human
embryonic stem cell lines |
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Sources for
Establishing Human Embryonic Stem Cell Lines |
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Human Embryonic Stem
Cell Lines with Genetic Disorders |
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Human Embryonic Stem
Cell Lines with Chromosomal Disorders |
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Genetic Disease
Specific Human Embryonic Stem Cell Lines |
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Development of
individual specific hESC lines |
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Human Embryonic Stem
Cell Lines Resistant to HIV |
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Progress in Study of
Disease specific hESC Lines |
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Social, ethical and
legal aspects |
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