Contributors

vii

Preface

xiii

Acknowledgments

xv

1

Molecular Biology of Cancer Part 1   Robert A. Kratzke

1

2

Molecular Biology of Cancer Part 2   Sunit Srivastava and George R. Simon

17

3

Etiology of Cancer Part 1   Shirish M. Gadgeel

33

4

Etiology of Cancer Part 2   Nikhil I. Khushalani and Kaunteya Reddy

57

5

Epidemiology of Cancer   Thomas E. Stinchcombe

69

6

Principles of Surgical Oncology   Rebecca L. Aft and Jason Keune

77

7

Principles of Radiation Oncology   Hak Choy and Nathan Kim

85

8

Principles of Medical Oncology   Sujatha Murali and Suresh S. Ramalingam

95

9

Principles of Immunotherapy   Sara K. Butler and Saiama N. Waqar

105

10

Health Services Research and Economics of Cancer Care   Kenneth R. Carson

115

11

Systemic Therapy for Cancer   Sara K. Butler and Leigh M. Boehmer

123

12

Cancer Prevention   Daniel Morgensztern and Vorachart Auethavekiat

135

13

Cancer Screening   Megan E. Wren

141

14

Genetic Counseling   Jennifer Ivanovich

149

15

Advances in Diagnostics and Intervention   Sanjeev Bhalla and Cylen Javidan-Nejad

161

16

Design and Analysis of Clinical Trials   Feng Gav and Kathryn Trinkaus

183

17

Cancer of the Head and Neck   David I. Kuperman

195

18

Cancer of the Lung   Saiama N. Waqar

205

19

Neoplasms of the Mediastinum   Gregory P. Kalemkerian

215

20

Cancer of the Gastrointestinal Tract   Renuka V. Iyer and Ravi Chhatrala

231

Section 1

Esophagus and Stomach

231

Section 2

Pancreas   Renuka V. Iyer and Ravi Chhatrala

243

Section 3

Hepatobiliary   Renuka V. Iyer and Ravi Chhatrala

252

Section 4

Small Intestine and Gastrointestinal Stromal Tumors   Benjamin R. Tan, Jr

261

Section 5

Colorectal and Anal Cancers   Benjamin R. Tan, Jr

268

21

Genitourinary Cancer   Walter M. Stadler

279

22

Cancer of the Testis   Saiama Waqar, Daniel Morgensztern, and Bruce Roth

297

23

Gynecologic Cancers

305

Section 1

Ovarian   David G. Mutch

305

Section 2

Nonovarian   Matthew A. Powell

314

24

Cancer of the Breast   Kathy D. Miller

331

25

Cancer of the Endocrine System   Rami Y. Haddad and Mouhammed Amir Habra

349

26

Sarcomas   Douglas R. Adkins, Brian A. Van Tine_, and Toni B. Rachocki

365

27

Cancer of the Skin and Melanoma   Gerald P. Linette

375

28

Neoplasms of the Central Nervous System   Janakiraman Subramanian and Gerald Linette

383

29

Cancers of Childhood   Shalini Shenoy

393

30

Lymphomas   Camille N. Abboud

413

31

Acute Leukemias   John Welch and Amanda R Cashen

437

32

Chronic Leukemias   James C. Mosley III and Keith Stockerl-Goldstein

449

33

Myelodysplastic Syndromes   Saiama N. Waqar

459

34

Plasma Cell Neoplasms   Ravi Vij and Giridharan Ramsingh

463

35

Cancer of Unknown Primary Site   Muhammad Atif Waqar

475

36

Benign and Malignant Mcsothelioma   Daniel Morgensztern

483

37

Peritoneal Carcinomatosis   Andrea Wang-Gillam and David D. Tran

487

38

Immunosupprcssion-Related Malignancies   Lee Ratner

497

39

Oncologic Emergencies   Giridharan Ramsingh and Daniel Morgensztern

503

40

Treatment of Metastatic Cancer   Kumar Rajagopalan

509

41

Paraneoplastic Syndromes   C. Daniel Kingsley and Michael C. Perry

517

42

Stem Cell Transplantation   Mark A. Schroeder and Peter Westervelt

525

43

Infections in the Cancer Patient   Alex E. Denes

539

44

Management of Adverse Effects of Treatment   Maria Q. Baggstrom

551

45

Supportive Care and Quality of Life   Anna Roshal

561

46

Rehabilitation of the Cancer Patient   Janakiraman Subramanian

573

47

Societal Issues in Oncology   Thomas H. Fong

581

48

Complementary, Alternative, and Integrative Therapies in Cancer Care   Vamsidhar Velcheti and Daniel Morgensztern

589

Index

597