Contributors

xi

Preface

xv

Important Notice (Please Read)

xvi

1

Introduction   Douglas D. Richman, Richard J. Whitley, and Frederick O. Hayden

1

SECTION I

VIRAL SYNDROMES AND GENERAL PRINCIPLES

5

2

Respiratory Infections   John J. Treanor

7

3

Viral Central Nervous System Infections   Kevin A. Cassady and Richard J. Whitley

29

4

Gastrointestinal Syndromes   Manish Patel and Roger I. Glass

45

5

Viral Hepatitis   Andrew W. Tai and Jules L. Dienstag

59

6

Infections in Organ Transplant Recipients   John A. Zaia

81

7

Viral Myocarditis   Jeffrey A. Towrin

97

8

Viral Infections of the Skin   Brenda L. Rartlett and Stephen K. Tyring

109

9

Viral Hemorrhagic Fevers: A Comparative Appraisal   Mike Bray and Karl M. Johnson

133

10

Viral Disease of the Eye   Garry Shuttleworth and David Easty

143

11

Antiretroviral Agents   Magdalena E. Sobieszczyk, Barbara S. Taylor, and Scott M. Hammer

167

12

Antiherpesvirus, Anti-Hepatitis Virus, and Anti-Respiratory Virus Agents   Michael T. Yin, James C.M. Brust, Hong Van Tieu, and Scott M. Hammer

217

13

Diagnosis of Viral Infections   Guy Boivin, Tony Mazzulli, Martin Petric, and Michel Couillard

265

14

Immune Responses to Viruses   Jonathan W. Yewdell, Theodore C. Pierson, and Jack R. Bennink

295

15

Immunization Against Viral Diseases   Julie E. Martin and Barney S. Graham

333

16

Gene Therapy and Viruses   Donald B. Kohn, Barrie J. Carter, Paolo Grandi, and Joseph C. Glorioso

351

17

Chronic Fatigue and Postinfective Fatigue Syndromes   Andrew R. Lloyd, Ian Hickie, and Denis Wakefield

371

SECTION II

THE AGENTS

385

PART A

DNA VIRUSES

18

Poxviruses   R. Mark Buller and Frank Fenner

387

19

Herpes Simplex Viruses   Richard J. Whitley and Bernard Roizman

409

20

Cercopithecine Herpesvirus 1 (B Virus)   Richard J. Whitley

437

21

Varicella-Zoster Virus   Anne A. Gershon and Saul J. Silverstein

451

22

Cytomegalovirus   Paul David Griffiths, Vincent Clive Emery, and Richard Milne

475

23

Human Herpesvirus 6 and Human Herpesvirus 7   Koichi Yamanishi and Yasuko Mori

507

24

Epstein-Barr Virus   Catherine Luzuriaga and John L. Sullivan

521

25

Kaposi’s Sarcoma-Associated Herpesvirus   Patrick S. Moore and Yuan Chang

537

26

Adenoviruses   Olli Ruuskanen, Jordan P. Metcalf, Olli Meurman, and Göran Akusjärvi

559

27

Polyomaviruses   John E. Greenlee and Frank J. O’Neill

581

28

Papillomavirus   William Bonnez

603

29

Human Parvoviruses   Larry J. Anderson and Dean D. Erdman

645

30

TT Virus   Peter Simmonds

663

31

Hepatitis B Virus   Alexander J.V. Thompson, Sally J. Bell, and Stephen A. Locarnini

673

PART B

RNA VIRUSES

32

Human Lymphotropic Viruses: HTLV-1 and HTLV-2   William A. Blattner and Manhattan E. Charurat

709

33

Human Immunodeficiency Virus   John C. Guatelli, Robert F. Siliciano, Daniel R. Kuritzkes, and Douglas D. Richman

737

34

Colorado Tick Fever Virus and Other Arthropod-Borne Reoviridae   Steven Yukl and Joseph K. Wong

785

35

Rotaviruses   Manuel A. Franco and Harry B. Greenberg

797

36

Respiratory Syncytial Virus, Human Metapneumovirus, and Parainfluenza Viruses   John V. Williams, Pedro A. Piedra, and Janet A. Englund

817

37

Measles Virus   William J. Moss and Diane E. Griffin

849

38

Mumps Virus   John W. Gnann, Jr.

877

39

Zoonotic Paramyxoviruses   Paul A. Rota, Thomas G. Ksiazek, and William J. Bellini

889

40

Rhabdoviruses   Thomas P. Bleck and Charles E. Rupprecht

905

41

Filoviruses   Mike Bray

923

42

Influenza Virus   Frederick G. Hayden and Peter Palese

943

43

Bunyaviridae: Bunyaviruses, Phleboviruses, Nairoviruses, and Hantaviruses   Gregory J. Mertz

977

44

Arenaviruses   C.J. Peters

1009

45

Enteroviruses   José R. Romero

1031

46

Rhinovirus   Ronald B. Turner and Wai-Ming Lee

1063

47

Hepatitis A Virus   Philip R. Spradling, Annette Martin, and Stephen M. Feinstone

1083

48

Human Caliciviruses   Robert L. Atmar and Mary K. Estes

1109

49

Hepatitis E Virus   David A. Anderson and Iswar L. Shrestha

1127

50

Astrovirus   Ernesto Méndkz and Carlos F. Arias

1145

51

Coronaviruses   Kenneth McIntosh and J.S.M. Peiris

1155

52

Arthropod-Borne Flaviviruses   Lyle R. Petersen and Alan D.T. Barrett

1173

53

Hepatitis C Virus   Yaron Rotman and T. Jake Liang

1215

54

Alphaviruses   David W. Smith, John S. Mackenzie, and Scott C. Weaver

1241

55

Rubella Virus   David W. Kimberlin

1275

PART C

SUBVIRAL AGENTS

56

Hepatitis D Virus   Antonina Smedile, Alessia Ciancio, and Mario Rizzetto

1291

57

Transmissible Spongiform Encephalopathies   Adriano Aguzzi

1307

Index

1325