Preface

ix

1

Blood Components

1

Concept of Blood Component Therapy

1

Whole Blood

6

Red Blood Cells

12

Red Blood Cells Leukocytes Reduced

14

Washed Red Blood Cells

17

Frozen Red Blood Cells; Deglycerolized Red Blood Cells

18

Platelets

20

Apheresis Granulocytes

27

Plasma Components

29

Cryoprecipitated Antihemophilic Factor (AHF)

32

Oxygen Therapeutics

34

Pathogen Reduction

34

References

35

2

Plasma Derivatives

45

Factor VIII Concentrates

45

Factor IX Concentrates

46

Other Recombinant and Plasma Protein Derivatives

47

Albumin and Plasma Protein Fraction

51

Synthetic Volume Expanders

53

Immune Globulin

55

Rh Immune Globulin

57

On the Horizon

60

References

61

3

Transfusion Practices

67

Surgical Blood Ordering Practices

67

Alternatives to Allogeneic Blood Transfusion

71

Urgent and Massive Transfusion

77

Solid Organ Transplantation

80

Obstetric and Neonatal Transfusion Practices

81

Management of Platelet Alloimmunization

89

Administration of Blood

91

References

95

4

Hemostatic Disorders

101

Overview of Hemostasis

101

Platelet Disorders

108

Congenital Bleeding Disorders

109

Acquired Bleeding Disorders

120

Prohemostatic Drugs

127

Thrombophilia

129

Disorders of Fibrinolysis

134

References

135

5

Adverse Effects of Blood Transfusion

141

Acute Transfusion Reactions

141

Delayed Transfusion Reactions

159

References

166

6

Hematopoietic Cellular Therapy

175

Concept of Hematopoietic Therapy

175

Marrow-Derived HPCs

176

HPCs Obtained by Apheresis

180

HPCs from Cord Blood

183

Donor Leukocyte Infusion

184

Hematopoietic Growth Factors

185

Nonmyeloablative HPC Transplantation

188

Dendritic Cells in HPC Transplantation

189

Transfusion Therapy in HPC Transplantation

189

References

193

7

Therapeutic Apheresis

203

Description

203

Indications

204

Procedural Considerations

217

Complications of Therapeutic Apheresis

219

References

220

Index

223