Preface

vii

1

Introduction to Therapeutic Apheresis: Principles, Physiology, and Patient Management

1

Introduction

1

Apheresis Instruments

2

Principles of Apheresis and Blood Component Exchange

5

Physiology of Therapeutic Apheresis

14

Patient Evaluation and Management

17

Adverse Events during Apheresis

27

References

35

2

Cytapheresis

41

Introduction

41

Thrombocytapheresis

43

Therapeutic Leukocytapheresis

45

Extracorporeal Photopheresis

51

Peripheral Blood Progenitor Cell Collection

57

Autologous MNCs Manipulated Ex Vivo

60

References

62

3

Therapeutic Plasma Exchange

69

Introduction

69

Hematologic Disorders and Dysproteinemias

69

Neurologic Diseases

93

Renal Diseases

104

Solid Organ Transplantation

109

Rheumatic Diseases

113

Metabolic Diseases

116

References

120

4

Erythrocytapheresis

137

Introduction

137

Standard Technique

137

Isovolemic Hemodilution

140

Urgent Need

141

Side Effects

141

Monitoring

142

Vascular Access

142

Indications

143

References

153

5

Pediatric Therapeutic Apheresis

159

Introduction

159

Technical Considerations

160

Adverse Reactions

168

Erythrocytapheresis

170

Therapeutic Plasma Exchange

175

Leukocytapheresis

181

References

185

6

Selective Depletion

191

Introduction

191

LDL Apheresis

192

Staphylococcal Protein a Immunoadsorption Columns

201

Membrane Differential Filtration

209

ABO Antigen-Specific Immunoadsorption

211

Liver Support Systems

212

Summary

213

References

219

Appendix

223

Index

233