Table
of Contents
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Introduction to Pattiophysiology |
xix |
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UNIT 1 |
CELL AND TISSUE FUNCTION |
1 |
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Chapter 1 |
Cell Structure and Function Edward W. Carroll |
1 |
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Functional Components of the Cell |
1 |
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Cell Metabolism and Energy Storage |
9 |
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Integration of Cell Function |
12 |
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Body Tissues |
20 |
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Chapter 2 |
Cellular Responses to Stress, Injury, and Aging Carrie J. Merkle |
33 |
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Cellular Responses to Persistent Stress |
33 |
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Cell Injury, Death, and Senescence |
38 |
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Chapter 3 |
Inflammation, the Inflammatory Response, and Fever |
51 |
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General Features of Inflammation |
51 |
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Acute Inflammation |
55 |
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Chronic Inflammation |
63 |
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Systemic Manifestations of Inflammation |
64 |
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Chapter 4 |
Cell Proliferation and Tissue Regeneration and Repair Carrie J. Merkle |
73 |
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Cell Proliferation and Tissue Regeneration |
73 |
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Healing by Connective Tissue Repair |
80 |
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Chapter 5 |
Genetic Control of Cell Function and Inheritance Edward W. Carroll |
89 |
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Genetic Control of Cell Function |
89 |
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Chromosomes |
97 |
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Patterns of Inheritance |
100 |
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Gene Technology |
103 |
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Chapter 6 |
Genetic and Congenital Disorders Genetic and Congenital Disorders |
109 |
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Genetic and Chromosomal Disorders |
109 |
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Disorders Due to Environmental Influences |
123 |
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Prenatal Screening and Diagnosis |
126 |
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Chapter 7 |
Neoplasia Carrie J. Merkle |
131 |
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Characteristics of Benign and Malignant Neoplasms |
131 |
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Etiology of Cancer |
139 |
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Clinical Manifestations |
146 |
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Screening, Diagnosis, and Treatment |
148 |
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Childhood Cancers |
154 |
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UNIT 2 |
INTEGRATIVE BODY FUNCTIONS |
159 |
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Chapter 8 |
Disorders of Fluid, Electrolyte, and Acid-Base
Balance Carol M. Porth and Kim A. Noble |
159 |
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Composition and Compartmental Distribution of Body Fluids |
159 |
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Sodium and Water Balance |
167 |
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Potassium Balance |
178 |
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Calcium and Magnesium Balance |
183 |
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Acid-Base Balance |
192 |
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Chapter 9 |
Stress and Adaptation Mary Pat Kunert |
209 |
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Stress and Adaptation |
209 |
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Disorders of the Stress Response |
218 |
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Chapter 10 |
Disorders of Nutritional Status Joan Pleuss and Glenn Matfin |
224 |
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Energy Metabolism and Nutritional Status |
224 |
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Overweight and Obesity |
231 |
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Undernutrition and Eating Disorders |
235 |
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UNIT 3 |
HEMATOPOIETIC FUNCTION |
243 |
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Chapter 11 |
Disorders of White Blood Cells and Lymphoid Tissues |
243 |
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Hematopoietic and Lymphoid Tissues |
243 |
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Nonneoplastic Disorders of White Blood Cells |
248 |
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Neoplastic Disorders of Hematopoietic and Lymphoid
Origin |
251 |
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Chapter 12 |
Disorders of Hemostasis Kathryn J. Gaspard |
263 |
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Hemostasis and Blood Coagulation |
263 |
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Hypercoagulability States |
269 |
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Bleeding Disorders |
271 |
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Chapter 13 |
Disorders of Red Blood Cells Kathryn J. Gaspard |
279 |
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The Red Blood Cell |
279 |
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Anemia |
284 |
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Polycythemia |
293 |
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Age-Related Changes in Red Blood Cells |
293 |
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UNIT 4 |
INFECTION AND IMMUNITY |
299 |
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Chapter 14 |
Mechanisms of Infectious Disease W. Michael Dunne
Jr. and Nathan A. Ledeboer |
299 |
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Infectious Diseases |
299 |
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Epidemiology of Infectious Diseases |
307 |
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Diagnosis and Treatment |
312 |
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New and Emerging Infectious Diseases |
316 |
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Chapter 15 |
Innate and Adaptive Immunity Cynthia Sommer |
319 |
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Introduction to the Immune System |
319 |
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Innate Immunity |
326 |
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Adaptive Immunity |
332 |
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Developmental Aspects of the Immune System |
342 |
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Chapter 16 |
Disorders of the Immune Response Judith A. Aberg
and Jason Faulhaber |
345 |
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Hypersensitivity Disorders |
345 |
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Transplantation Immunopathology |
353 |
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Autoimmune Disease |
355 |
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Immunodeficiency Disorders |
359 |
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UNIT 5 |
CIRCULATORY FUNCTION |
377 |
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Chapter 17 |
Control of Cardiovascular Function |
377 |
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Organization of the Circulatory System |
377 |
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Principles of Blood Flow |
380 |
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The Heart as a Pump |
384 |
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The Systemic Circulation and Control of Blood Flow |
396 |
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Neural Control of Circulatory Function |
402 |
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Chapter 18 |
Disorders of Blood Flow and Blood Pressure Glenn Matfin and Carol M. Porth |
405 |
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Blood Vessel Structure and Function |
405 |
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Disorders of the Arterial Circulation |
407 |
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Disorders of Arterial Blood Pressure |
422 |
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Disorders of the Venous Circulation |
439 |
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Chapter 19 |
Disorders of Cardiac Function Toni Balistrieri and Kathleen Mussatto |
447 |
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Disorders of the Pericardium |
447 |
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Coronary Artery Disease |
450 |
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Cardiomyopathies |
461 |
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Endocardial and Valvular Disorders |
466 |
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Heart Disease in Infants and Children |
474 |
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Chapter 20 |
Heart Failure and Circulatory Shock Anna Barkman and Charlotte Pooler |
486 |
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Heart Failure |
486 |
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Circulatory Failure (Shock) |
499 |
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Heart Failure in Children and the Elderly |
508 |
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UNIT 6 |
RESPIRATORY FUNCTION |
513 |
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Chapter 21 |
Control of Respiratory Function |
513 |
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Structural Organization of the Respiratory System |
513 |
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Exchange of Gases Between the Atmosphere and the Lungs |
520 |
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Exchange and Transport of Gases |
528 |
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Control of Breathing |
536 |
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Chapter 22 |
Respiratory Tract Infections, Neoplasms, and Childhood
Disorders |
540 |
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Respiratory Tract Infections |
540 |
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Cancer of the Lung |
554 |
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Respiratory Disorders in Children |
557 |
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Chapter 23 |
Disorders of Ventilation and Gas Exchange Charlotte Pooler |
566 |
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Physiologic Effects of Ventilation and Diffusion Disorders |
566 |
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Disorders of Lung Inflation |
569 |
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Obstructive Airway Disorders |
573 |
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Interstitial Lung Diseases |
586 |
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Disorders of the Pulmonary Circulation |
589 |
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Acute Respiratory Disorders |
593 |
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UNIT 7 |
KIDNEY AND URINARY TRACT FUNCTION |
601 |
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Chapter 24 |
Structure and Function of the Kidney |
601 |
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Kidney Structure and Function |
601 |
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Tests of Renal Function |
616 |
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Chapter 25 |
Disorders of Renal Function |
620 |
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Disorders of Glomerular Function |
620 |
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Tubulointerstitial Disorders |
627 |
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Cystic Diseases of the Kidney |
630 |
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Obstructive Disorders |
633 |
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Malignant Tumors of the Kidney |
637 |
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Chapter 26 |
Acute Renal Failure and Chronic Kidney Disease |
641 |
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Acute Renal Failure |
641 |
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Chronic Kidney Disease |
645 |
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Chronic Kidney Disease in Children and Elderly Persons |
655 |
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Chapter 27 |
Disorders of the Bladder and Lower Urinary Tract |
659 |
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Control of Urine Elimination |
659 |
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Disorders of Bladder Structure and Function |
663 |
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Urinary Tract Infections |
671 |
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Cancer of the Bladder |
675 |
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UNIT 8 |
GASTROINTESTINAL AND HEPATOBILIARY FUNCTION |
679 |
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Chapter 28 |
Structure and Function of the Gastrointestinal System |
679 |
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Structure and Organization of the Gastrointestinal Tract |
679 |
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Motility |
684 |
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Hormonal, Secretory, and Microflora
Functions |
690 |
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Digestion and Absorption |
694 |
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Anorexia, Nausea, and Vomiting |
697 |
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Chapter 29 |
Disorders of Gastrointestinal Function |
700 |
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Disorders of the Esophagus |
700 |
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Disorders of the Stomach |
705 |
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Disorders of the Small and Large Intestines |
710 |
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Chapter 30 |
Disorders of Hepatobiliary and Exocrine
Pancreas Function |
729 |
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The Liver and Hepatobiliary System |
729 |
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Disorders of Hepatic and Biliary Function |
737 |
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Disorders of the Gallbladder and Exocrine Pancreas |
752 |
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UNIT 9 |
ENDOCRINE SYSTEM |
761 |
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Chapter 31 |
Mechanisms of Endocrine Control Glenn Matfin |
761 |
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The Endocrine System |
761 |
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Chapter 32 |
Disorders of Endocrine Control of Growth and Metabolism Glenn Matfin |
774 |
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General Aspects of Altered Endocrine Function |
774 |
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Pituitary and Growth Disorders |
775 |
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Thyroid Disorders |
782 |
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Disorders of Adrenal Cortical Function |
790 |
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Chapter 33 |
Diabetes Mellitus and the Metabolic Syndrome Safak Guven,
Glenn Matfin,
and Julie A. Kuenzi |
799 |
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Hormonal Control of Nutrient Metabolism and Storage |
799 |
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Diabetes Mellitus |
805 |
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UNIT 10 |
NERVOUS SYSTEM |
829 |
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Chapter 34 |
Organization and Control of Neural Function Edward W. Carroll
and Robin Curtis |
829 |
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Nervous Tissue Cells |
829 |
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Nerve Cell Communication |
833 |
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Developmental Organization of the Nervous System |
837 |
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Spinal Cord and Brain |
845 |
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The Autonomic Nervous System |
855 |
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Chapter 35 |
Somatosensory Function, Pain, and
Headache Kim A. Noble and Kim Litwack |
863 |
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Organization and Control of Somatosensory
Function |
863 |
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Pain Sensation |
870 |
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Alterations in Pain Sensitivity and Special Types of Pain |
880 |
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Headache and Associated Pain |
883 |
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Pain in Children and Older Adults |
886 |
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Chapter 36 |
Disorders of Neuromuscular Function Serena W. Hung |
891 |
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Organization and Control of Motor Function |
891 |
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Disorders of the Motor Unit |
899 |
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Disorders of the Cerebellum and Basal Ganglia |
908 |
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Upper Motor Neuron Disorders |
913 |
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Chapter 37 |
Disorders of Brain Function Diane S. Book |
927 |
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Mechanisms and Manifestations of Brain Injury |
927 |
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Cerebrovascular Disease |
941 |
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Infections and Brain Tumors |
951 |
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Seizure Disorders |
955 |
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Disorders of Memory and Cognition |
959 |
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Chapter 38 |
Disorders of Special Sensory Function: Vision, Hearing, and Vestibular
Function Edward W. Carroll
and Scott A. Jens, Disorders of Vision; Susan A. Fontana, Disorders of Hearing and Vestibular Function |
966 |
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The Eye and Disorders of Vision |
966 |
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The Ear and Disorders of Auditory Function |
988 |
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The Vestibular System and Disorders of Equilibrium |
1000 |
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UNIT 11 |
GENITOURINARY AND REPRODUCTIVE FUNCTION |
1009 |
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Chapter 39 |
Disorders of the Male Genitourinary System Glenn Matfin |
1009 |
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Physiologic Basis of Mole Reproductive Function |
1009 |
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Disorders of the Penis, the Scrotum and Testes, and the Prostate |
1016 |
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Disorders in Childhood and Aging Changes |
1028 |
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Chapter 40 |
Disorders of the Female Genitourinary System Patricia McCowen Mehring |
1033 |
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Structure and Function of the Female Reproductive System |
1033 |
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Disorders of the Female Reproductive Organs |
1041 |
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Menstrual Disorders |
1055 |
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Disorders of the Breast |
1059 |
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Chapter 41 |
Sexually Transmitted Infections Patricia McCowen Mehring |
1067 |
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Infections of the External Genitalia |
1068 |
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Vaginal Infections |
1072 |
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Vaginal-Urogenital-Systemic
Infections |
1074 |
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UNIT 12 |
MUSCULOSKELETAL FUNCTION |
1081 |
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Chapter 42 |
Structure and Function of the Skeletal System |
1081 |
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Structures of the Skeletal System |
1081 |
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Joints |
1092 |
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Chapter 43 |
Disorders of the Skeletal System: Trauma, Infections, Neoplasms,
and Childhood Disorders Kathleen E. Gunta |
1096 |
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Injury and Trauma of Musculoskeletal Structures |
1096 |
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Bone Infections and Osteonecrosis |
1109 |
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Neoplasms |
1113 |
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Skeletal Disorders in Children |
1116 |
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Chapter 44 |
Disorders of the Skeletal System: Metabolic and Rheumatic
Disorders Kathleen E.
Gunta, Metabolic Disorders; Debra Bancroft
Rizzo, Rheumatic Disorders |
1130 |
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Metabolic Bone Disease |
1130 |
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Rheumatic Disorders |
1138 |
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Rheumatic Diseases in Children and the Elderly |
1531 |
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UNIT 13 |
INTEGUMENTARY FUNCTION |
1159 |
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Chapter 45 |
Structure and Function of the Skin Gladys Simandl |
1159 |
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Structure and Function of the Skin |
1159 |
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Manifestations of Skin Disorders |
1166 |
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Chapter 46 |
Disorders of Skin Integrity and Function Gladys Simandl |
1172 |
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Primary Disorders of the Skin |
1172 |
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Ultraviolet Radiation, Thermal, and Pressure Injury |
1188 |
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Nevi and Skin Cancers |
1194 |
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Age-Related Skin Manifestations |
1198 |
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Glossary |
1207 |
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Appendix A |
Laboratory Values |
1217 |
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Index |
1219 |
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