Table of Contents
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Contributors |
xix |
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Acknowledgments |
xxv |
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Introduction Stephen J. Ferrando,
M.D., James L. Levenson, M.D. and James A. Owen, Ph.D. |
xxvii |
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PART I |
GENERAL PRINCIPLES |
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1 |
Pharmacokinetics,
Pharmacodynamics,
and Principles of Drug-Drug Interactions James A. Owen, Ph.D. |
3 |
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Pharmacodynamics |
4 |
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Pharmacokinetics |
7 |
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Drug-Drug
Interactions |
20 |
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Key Clinical Points |
25 |
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References |
27 |
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Appendix: Drugs with
Clinically Significant Pharmacokinetic Interactions |
30 |
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2 |
Severe Drug
Reactions |
39 |
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Central Nervous
System Reactions |
40 |
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Cardiovascular
Reactions |
49 |
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Gastrointestinal
Reactions |
55 |
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Renal Reactions |
58 |
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Hematological
Reactions |
64 |
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Metabolic Reactions
and Body as a Whole |
66 |
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Key Clinical Points |
71 |
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References |
72 |
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3 |
Alternate
Routes of Drug Administration James A. Owen, Ph.D. |
79 |
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Properties of
Specific Routes of Administration |
80 |
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Psychotropic
Medications |
87 |
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Conclusion |
94 |
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Key Clinical Points |
95 |
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References |
96 |
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PART II |
PSYCHOPHARMACOLOGY
IN ORGAN SYSTEM DISORDERS AND SPECIALTY AREAS |
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4 |
Gastrointestinal
Disorders Catherine C. Crone, M.D., Michael Marcangelo,
M.D., Jeanne Lackamp, M.D., Andrea F. DiMartini,
M.D. and James A. Owen, Ph.D. |
103 |
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Oropharyngeal Disorders |
104 |
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Esophageal and
Gastric Disorders |
106 |
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Intestinal Disorders |
111 |
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Liver Disorders |
115 |
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Gastrointestinal
Side Effects of Psychiatric Drugs |
123 |
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Psychotropic
Drug-Induced Gastrointestinal Complications |
126 |
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Psychiatric Side
Effects of Gastrointestinal Medications |
130 |
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Drug-Drug
Interactions |
132 |
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Conclusion |
132 |
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Key Clinical Points |
138 |
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References |
139 |
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5 |
Renal and
Urological Disorders James A. Owen, Ph.D. and James L. Levenson,
M.D. |
149 |
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Differential
Diagnosis |
150 |
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Pharmacotherapy in
Renal Disease |
152 |
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Psychiatric Adverse
Effects of Renal and Urological Agents |
161 |
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Renal and Urological
Adverse Effects of Psychotropics |
164 |
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Drug-Drug
Interactions |
166 |
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Key Clinical Points |
175 |
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References |
175 |
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6 |
Cardiovascular
Disorders Peter A. Shapiro, M.D. |
181 |
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Differential
Diagnostic Considerations |
182 |
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Neuropsychiatric Side Effects of
Cardiac Medications |
183 |
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Alterations in
Pharmacokinetics in Heart Disease |
184 |
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Psychotropic
Medication Use in Heart Disease |
187 |
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Drug-Drug
Interactions |
199 |
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Key Clinical Points |
207 |
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References |
207 |
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7 |
Respiratory
Disorders Wendy L. Thompson, M.D. and Yvette L. Smolin,
M.D. |
213 |
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Differential
Diagnostic Considerations |
214 |
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Neuropsychiatric Side Effects of
Respiratory Drugs |
216 |
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Alteration of
Pharmacokinetics |
219 |
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Prescribing
Psychotropic Medications in Respiratory Disease |
220 |
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Effects of
Psychotropic Drugs on Pulmonary Diseases |
225 |
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Drug-Drug
Interactions |
227 |
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Key Clinical Points |
230 |
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References |
230 |
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8 |
Oncology James A. Owen, Ph.D.
and Stephen J. Ferrando, M.D. |
237 |
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Differential
Diagnosis of Psychiatric Manifestations of Cancers |
238 |
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Psychopharmacological
Treatment of Psychiatric Disorders in Cancer Patients |
239 |
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Adverse Oncological
Effects of Psychotropics |
244 |
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Neuropsychiatric Adverse Effects of
Oncology Treatments |
247 |
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Drug-Drug
Interactions |
251 |
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Key Clinical Points |
260 |
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References |
261 |
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9 |
Central Nervous
System Disorders Saeed Salehinia,
M.D. and Vani
Rao,
M.D. |
271 |
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Dementia |
272 |
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Stroke |
275 |
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Traumatic Brain
Injury |
.276 |
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Multiple Sclerosis |
278 |
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Parkinson's Disease |
280 |
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Huntington's Disease |
282 |
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Epilepsy |
283 |
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Symptoms and
Syndromes Common Across Neurological Disorders |
285 |
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Adverse Neurological
Effects of Psychotropic Drugs |
286 |
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Adverse Psychiatric
Effects of Neurological Drugs |
289 |
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Drug-Drug
Interactions |
291 |
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Key Clinical Points |
296 |
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References |
297 |
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10 |
Endocrine
and Metabolic Disorders Stephen J. Ferrando,
M.D. and Jennifer Kraker, M.D., M.S. |
305 |
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Diabetes Mellitus |
306 |
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Thyroid Disorders |
309 |
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Pheochromocytoma |
311 |
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Antidiuretic Hormone |
311 |
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Reproductive
Endocrine System Disorders |
312 |
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Hypogonadal Disorders |
312 |
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Endocrinological Side Effects of
Psychiatric Medications |
313 |
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Psychiatric Side
Effects of Endocrine Treatments |
320 |
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Drug-Drug
Interactions |
324 |
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Key Clinical Points |
328 |
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References |
328 |
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11 |
Obstetrics
and Gynecology Margaret Altemus,
M.D. and Mallay
Occhiogrosso,
M.D. |
339 |
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Differential
Diagnosis |
340 |
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Pharmacotherapy of
Premenstrual Mood Symptoms |
342 |
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Pharmacotherapy of
Menopause-Related Depression, Anxiety, and Insomnia |
343 |
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Psychopharmacology
in Pregnancy and Breastfeeding |
343 |
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Adverse Obstetric
and Gynecological Reactions to Psychotropic Drugs |
354 |
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Psychiatric Adverse
Effects of Obstetric and Gynecological Agents and Procedures |
355 |
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Drug-Drug
Interactions |
358 |
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Key Clinical Points |
361 |
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References |
362 |
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12 |
Infectious
Diseases Stephen J. Ferrando, M.D., James L. Levenson,
M.D. and James A. Owen, Ph.D. |
371 |
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Bacterial Infections |
372 |
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Viral Infections |
374 |
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Parasitic
Infections: Neurocysticercosis |
393 |
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Adverse Psychiatric
Effects of Antibiotics |
393 |
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Drug-Drug
Interactions |
394 |
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Key Clinical Points |
395 |
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References |
396 |
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13 |
Dermatological
Disorders Madhulika A. Gupta, M.D.,
F.R.C.P.C. and James L. Levenson, M.D. |
405 |
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Differential
Diagnosis |
406 |
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Pharmacotherapy of
Specific Disorders |
409 |
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Adverse Cutaneous
Drug Reactions to Psychotropic Agents |
415 |
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Adverse Psychiatric
Effects of Dermatological Agents |
420 |
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Drug-Drug
Interactions |
422 |
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Key Clinical Points |
423 |
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References |
424 |
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14 |
Rheumatological Disorders James L. Levenson,
M.D. and Stephen J. Ferrando, M.D. |
431 |
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Treatment of
Psychiatric Disorders |
432 |
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Psychiatric Side
Effects of Rheumatological Medications |
433 |
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Rheumatological Side Effects of
Psychotropic Medications: Psychotropic Drug-Induced Lupus |
434 |
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Drug-Drug
Interactions |
435 |
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Key Clinical Points |
435 |
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References |
436 |
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15 |
Surgery and
Critical Care Stephen J. Ferrando,
M.D., James L. Levenson, M.D. and James A. Owen, Ph.D. |
439 |
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Delirium |
440 |
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Psychotropic Drugs
in the Perioperative
Period |
447 |
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Treatment of
Preoperative Anxiety |
449 |
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Acute and
Posttraumatic Stress in the Critical Care Setting |
451 |
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Adverse Neuropsychiatric
Effects of Critical Care and Surgical Drugs |
453 |
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Drug-Drug
Interactions |
454 |
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Key Clinical Points |
460 |
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References |
462 |
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16 |
Organ
Transplantation Andrea F. DiMartini,
M.D., Catherine C. Crone, M.D. and Marian Fireman, M.D. |
469 |
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Posttransplant Pharmacological
Considerations |
470 |
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Psychotropic
Medications in Transplant Patients |
475 |
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Drug-Specific Issues |
484 |
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Conclusion |
491 |
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Key Clinical Points |
491 |
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References |
492 |
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17 |
Pain
Management Michael R. Clark, M.D., M.P.H. and James A.
Owen, Ph.D. |
501 |
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Psychiatric Comorbidity |
502 |
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Pain Description and
Management |
504 |
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Pharmacological
Treatment |
510 |
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Drug-Drug
Interactions |
522 |
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Key Clinical Points |
524 |
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References |
525 |
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18 |
Substance
Use Disorders José Maldonado, M.D., F.A.R.M., F.A.C.F.E.,
Andrea F. DiMartini, M.D. and James A. Owen, Ph.D. |
537 |
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Drugs for Substance
Intoxication |
538 |
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Drugs for Substance
Use Disorders |
539 |
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Psychiatric Adverse
Effects of Drugs Used in Substance Use Disorders |
547 |
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Drug-Drug
Interactions |
547 |
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Key Clinical Points |
549 |
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References |
552 |
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Index |
557 |
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