Table
of Contents
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Preface |
v |
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Contributors |
xi |
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SECTION I |
EXPERIMENTAL APPROACHES IN CANCER THERAPY |
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SUBSECTION A |
INTRODUCTION |
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1 |
The Development of Gene
Therapy: From Monogenic Recessive Disorders to Complex Diseases Such as
Cancer Jean-Pierre Gillet,
Benjamin Macadangdang,
Robert L. Fathke, Michael M. Gottesman,
and Chava
Kimchi-Sarfaty |
5 |
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SUBSECTION B |
VECTOROLOGY FOR CANCER GENE THERAPY |
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2 |
Designing Adenoviral
Vectors for Tumor-Specific Targeting Ramon Alemany |
57 |
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3 |
Analysis of HSV Oncolytic
Virotherapy
in Organotypic
Cultures Giutia Fulci and Brent Passer |
75 |
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4 |
Use of Minicircle
Ptasmids
for Gene Therapy Peter
Mayrbofer,
Martin Scbleef,
and Wolfgang Jechlinger |
87 |
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5 |
Transposable Elements
as Plasmid-Based Vectors for Long-Term Gene Transfer into
Tumors John R. Ohlfest,
Zoltán
Ivies, and Zsussanna Izsvák |
105 |
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6 |
Designing Plasmid
Vectors Oleg Tolmaehov |
117 |
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7 |
Development of
Bacterial Vectors for Tumor-Targeted Gene Therapy Li-Jun Jia and Zi-Chun
Hua |
131 |
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SUBSECTION C |
NONVIRAL TRANSFER TECHNOLOGIES IN CANCER GENE THERAPY |
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8 |
Electroporative Gene
Transfer Marco Schmeer |
157 |
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9 |
Gene Gun Delivery
Systems for Cancer Vaccine Approaches Kandan
Aravindaram
and Ning
Sun Yang |
167 |
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10 |
Ultrasound-Mediated
Gene Transfection Loreto B. Feril
Jr. |
179 |
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11 |
Nonviral Jet-Injection
Technology for Intratumoral In Vivo Gene Transfer of Naked
DNA Wolfgang Walther, Iduna
Fichtner,
Peter M. Sehlag, and Ulrike S. Stein |
195 |
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SUBSECTION D |
EXPERIMENTAL STUDIES IN CANCER GENE THERAPY |
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12 |
Methods for
Constructing and Evaluating Antitumor DNA
Vaccines Brian M.
Olson and Douglas G. McNeel |
211 |
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13 |
Immunity of Lentiviral
Vector-Modified Dendritic Cells Shuhong Han and Lung-Ji Chang |
245 |
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14 |
Saporin Suicide Gene
Therapy Natasa Zarovni, Riccardo Vago,
and Maria Serena Fabbrini |
261 |
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15 |
Using In Vivo Biopanning
for the Development of Radiation-Guided Drug Delivery
Systems Jerry J. Jaboin,
Zhaozhong
Han, and Dennis E. Hallahan |
285 |
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16 |
Chemosensitization of
Tumor Cells: Inactivation of Nuclear Factor-Kappa B Associated with Chemosensitivity
in Melanoma Cells After Combination Treatment with E2F-1 and
Doxorubicin Hongying Hao, H. Sam Zhou, and Kelly
M. McMasters |
301 |
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17 |
Induction of Tumor Cell
Apoptosis by TRAIL Gene Therapy Thomas S. Griffith |
315 |
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18 |
Silencing Epidermal
Growth Factor Receptor by RNA Interference in Glioma Chunsheng Kang, Peiyu Pu,
and Hao
Jiang |
335 |
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19 |
Delivery of Phosphorodiamidate
Morpholino
Antisense
Oligomers
in Cancer Cells Gayathri R. Devi |
351 |
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20 |
Use of RNA Aptamers
for the Modulation of Cancer Cell Signaling Sunjoo Jeong, Hee Kyu
Lee, and Mee
Young Kim |
363 |
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21 |
G-Rich Oligonucleotides
for Cancer Treatment Paula
J. Bates, Enid W. Choi, and Lalitha
V. Nayak |
379 |
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SECTION II |
CLINICAL APPROACHES IN CANCER GENE THERAPY |
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SUBSECTION A |
REQUIREMENTS FOR CLINICAL GENE THERAPY TRIALS |
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22 |
Regulatory Aspects for
Translating Gene Therapy Research into the Clinic Carolyn M. Laurencot
and Sheryl Ruppel |
397 |
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23 |
Ethics of Cancer Gene
Transfer Clinical Research Jonathan Kimmelman |
423 |
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24 |
Virus Production for
Clinical Gene Therapy Tiago Vicente, Cristina Peixoto,
Manuel J.T. Carrondo, and Paula M. Alves |
447 |
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25 |
Production of Plasmid
DNA as Pharmaceutical Martin
Scbleefand
Markus Blaesen |
471 |
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SUBSECTION B |
CLINICAL PROTOCOLS IN CANCER GENE THERAPY |
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26 |
Gene Immunotherapy for
Non-Small Cell Lung Cancer John J. Nemunaitis |
499 |
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27 |
Gene Therapy for Antitumor
Vaccination Seungbee Kim-Scbulze
and Howard L. Kaufman |
515 |
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28 |
HSV-tk/IL-2 Gene
Therapy for Glioblastoma Multiforme Luisn Barzon, Monta Pacenti,
Elisa Franchin,
Federico Colombo, and Giorgio Palů |
529 |
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29 |
Construction and
Characterization of an Oncolytic HSV Vector
Containing a Fusogenic Glycoprotein and Prodrug
Activation for Enhanced Local Tumor Control Guy R. Simpson and Robert S. Coffin |
551 |
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30 |
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565 |
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31 |
Oncolytic Viral Therapy Using Reovirus Cbandini Thirukkumaran and Don G.
Morris |
607 |
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32 |
Design and Testing of
Novel Oncolytic
Vaccinia
Strains Steve H. Tborne |
635 |
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33 |
Tumor-Targeted
Salmonella typhimurium Overexpressing
Cytosine Deaminase:
A Novel, Tumor-Selective Therapy Ivan King, Martina Itterson, and David Bermudes |
649 |
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34 |
Chemoprotection by
Transfer of Resistance Genes Tulin
Budak-Alpdogan
and Joseph R. Bertino |
661 |
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35 |
Phase I Clinical Trial
of Locoregional
Administration of the Oncolytic Adenovirus
ONYX-015 in Combination with Mitomycin-C, Doxorubicin,
and Cisplatin
Chemotherapy in Patients with Advanced Sarcomas Mateusz Opyrchal, Ileana Aderca,
and Evanthia
Galanis |
705 |
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Index |
719 |
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