PART I

CRANIAL NEURO-ONCOLOGY

1

Pathology and Classification of Tumors of the Nervous System   Guido Reifenberger, Ingmar Blümcke, Torsten Pietsch, and Werner Paulus

3

2

Targeted Therapies   Manfred Westphal and Katrin Lamszus

77

3

Tumors of the Skull   Roland Goldbrunner

87

4

Meningiomas and Meningeal Tumors   Manfred Westphal, Katrin Lamszus, and Jörg-Christian Tonn

95

5

Low-Grade Astrocytomas   Nader Sanai and Mitchel S. Berger

119

6

Stereotactic Brachytherapy in Low-Grade Gliomas   Friedrich W. Kreth and Jan H. Mehrkens

135

7

High-Grade Astrocytoma/Glioblastoma   Jon D. Weingart, Matthew J. McGirt, and Henry Brem

147

8

Oligodendroglioma   Silvia Hofer, Caroline Happold, and Michael Weller

163

9

Ependymomas and Ventricular Tumors   Manfred Westphal

171

10

Medulloblastoma-PNET, Craniopharyngioma Adult Tumors of Pediatric Origin   Aurelia Peraud, Jörg-Christian Tonn, and James T. Rutka

189

11

Glioneuronal Tumors   Matthias Simon, Rudolf A. Kristof, and Johannes Schramm

195

12

Inactive Adenomas   John A. Jane Jr, Aaron S. Dumont, Jason P. Sheehan, and Edward R. Laws Jr

211

13

Functioning Adenomas   Dieter K. Lüdecke, Takumi Abe, Jörg Flitsch, Stephan Petersenn, and Wolfgang Saeger

219

14

Tumors of the Pineal Region   Yutaka Sawamura, Ivan Radovanovic, and Nicolas de Tribolet

239

15

Tumors of the Cranial Nerves   Berndt Wowra and Jörg-Christian Tonn

251

16

Hemangioblastoma and Von Hippel-Lindau Disease   Juha E. Jääskeläinen and Mika Niemelä

269

17

Tumors of the Skull Base   Kadir Erkmen, Ossama Al-Mefty, and Badih Adada

279

18

Orbital Tumors   Christoph Hintschich and Geoff Rose

309

19

Primary CNS Lymphoma   Joachim M. Baehring, Uwe Schlegel, and Fred H. Hochberg

331

20

Brain Metastasis   Zeena Dorai, Raymond Sawaya, and W.K. Alfred Yung

345

PART II

PEDIATRIC NEURO-ONCOLOGY

21

Neurocutaneous Syndromes   Paul Kongkham and James T. Rutka

365

22

Supratentorial Hemispheric Low-Grade Gliomas in Children   Paul Chumas and Atul Tyagi

385

23

Optic Gliomas   Ian F. Pollack and Regina I. Jakacki

395

24

Thalamic Gliomas   Christian Sainte-Rose, Darach W. Crimmins, and Jacques Grill

405

25

Midbrain Gliomas   Leland Albright and Brandon G. Rocque

419

26

Supratentorial High-Grade Gliomas   Phiroz E. Tarapore, Anu Banerjee, and Nalin Gupta

427

27

Ganglioglioma   Concezio Di Rocco and Gianpiero Tamburrini

435

28

Cerebellar Astrocytomas   David F. Bauer and John C. Wellons III

445

29

Diffuse Intrinsic Pontine Gliomas   Milind Ronghe, Takaaki Yanagisawa, and Eric Bouffet

453

30

Dorsally Exophytic Brain Stem Gliomas   Ian D. Kamaly-Asl and James M. Drake

461

31

Cervicomedullary Gliomas   Jeffrey C. Mai and Richard G. Ellenbogen

467

32

Desmoplastic Infantile Ganglioglioraas   Jeffrey P. Blount and David F. Bauer

477

33

Pleomorphic Xanthoastrocytoma   Jean-Pierre Fanner and Michele Parolin

483

34

Hypothalamic Hamartoma   Jeffrey V. Rosenfeld and A. Simon Harvey

491

35

Ependymomas   Nicholas Wetjen and Corey Raffel

503

36

Medulloblastoma   Shobhan Vachhrajani and Michael D. Taylor

513

37

Supratentorial Primitive Neuroectodermal Tumors   Ash Singhal, Shahid Gul, and Paul Steinbok

525

38

Dysembryoplastic Neuroectodermal Tumors   Aurelia Peraud, Jörg-Christian Tonn, and James T. Rutka

533

39

Meningiomas in Children   Abhaya V. Kulkarni and Patrick J. McDonald

539

40

Pineal Region Tumors in Children   Anna J. Janss and Timothy B. Mapstone

545

41

Pituitary Tumors in Children   Nader Pouratian, Aaron S. Dumont, Jay Jagannathan, and John A. Jane Jr

553

42

Craniopharyngiomas   Rémy van Effenterre and Anne-Laure Boch

559

43

Intracranial Germ Cell Tumors   Kyu-Chang Wang, Seung-Ki Kim, Sung-Hye Park, In-One Kim, Ji Hoon Phi, and Byung-Kyu Cho

571

44

Choroid Plexus Tumors   Paul Kongkham and James T. Rutka

587

45

Malignant Rhabdoid Tumors of the CNS   Michael R. Carter

597

46

Langerhans Cell Histiocytosis   Walter J. Hader and Clare Gallagher

607

47

Tumors of the Skull Base in Children   Eve C. Tsai, Gregory Hawryluk, and James T. Rutka

615

48

Tumors of the Cranial Vault in Children   John R.W. Kestle

629

49

Epidural Spinal Tumors in Children   Krystal Thorington, Colin Kazina, and Patrick McDonald

637

50

Spinal Column Tumors   Joshua J. Chern, Andrew Jea, William E. Whitehead, and Anna Illner

645

51

Pediatric Spinal Intradural Extramedullary Tumors   Peter Dirks

663

52

Intramedullary Spinal Tumors in Children   John S. Myseros

667

53

Peripheral Nerve Tumors in Children   Forrest Hsu and Rajiv Midha

675

PART III

SPINAL NEURO-ONCOLOGY

54

Intramedullary Tumors   Manfred Westphal

689

55

Intradural Extramedullary Tumors   Roland Goldbrunner

709

56

Epidural Tumors and Metastases   Rory J. Petteys, Wesley Hsu, Carlos A. Bagley, and Ziya L. Gokaslan

719

57

Spinal Robotic Radiosurgery   Alexander Muacevic, Bernd Wowra, and Jörg-Christian Tonn

739

PART IV

PERIPHERAL NERVE TUMORS

58

Peripheral Nerve Tumors   Joseph Wiley, Asis Kumar Bhattacharyya, Gelareh Zadeh, Patrick Shannon, and Abhijit Guha

747

PART V

SYSTEMIC AND GENERAL ASPECTS OF NEURO-ONCOLOGY

59

General Care of Patients with Cancer Involving the Central Nervous System   Stuart A. Grossman

771

60

Palliative Care in Neuro-Oncology   G.D. Borasio, C. Bausewein, S. Lorenzl, R. Voltz, and M. Wasner

783

Index

789