1

Historical Aspects   Jean-Marie Lachapelle

1

PART I

BASIC FEATURES

2

Genetics and Individual Predispositions in Contact Dermatitis   Axel Schnuch and Berit Christina Carlsen

13

3

Mechanisms of Irritant and Allergic Contact Dermatitis   Thomas Rustemeyer, Ingrid M.W. van Hoogstraten, B. Mary E. von Blomberg, Sue Gibbs, and Rik J. Scheper

43

4

Molecular Aspects in Allergic and Irritant Contact Dermatitis   Jean-Pierre Lepoittevin

91

5

Bio-Guided Fractionation and Identification of Allergens in Complex Mixtures and Products   Elena Giménez-Arnau

111

6

Role of the Permeability Barrier in Contact Dermatitis   Ehrhardt Proksch and Jochen Brasch

121

7

Immediate Contact Reactions   David Basketter and Arto Lahti

137

8

Mechanisms of Phototoxic and Photoallergic Reactions   Renz Mang, Helger Stege, and Jean Krutmann

155

PART II

PATHOLOGY

9

Histopathological and Immunohistopathological Features of Irritant and Allergic Contact Dermatitis   Jean-Marie Lachapelle and Liliane Marot

167

10

Ultrastructure of Irritant and Allergic Contact Dermatitis   Carolyn M. Willis

179

11

Epidemiology   Pieter-Jan Coenraads, Wolfgang Uter, and Thomas Diepgen

193

PART III

DERMATOTOXICOLOGY

12

Skin Penetration   Hans Schaefer, Thomas E. Redelmeier, and Jürgen Lademann

215

13

Predictive Tests for Irritants and Allergens and their Use in Quantitative Risk Assessment   David Basketter and Ian Kimber

229

14

Allergic Contact Dermatitis in Humans: Experimental and Quantitative Aspects   Jeanne Duus Johansen, Peter J. Frosch, and Torkil Menné

241

PART IV

CLINICAL FEATURES

15

Clinical Features   Niels K. Veien

255

16

Clinical Aspects of Irritant Contact Dermatitis   Peter J. Frosch and Swen Malte John

305

17

Systemic Contact Dermatitis   Niels K. Veien and Torkil Menné

347

18

Phototoxic and Photoallergic Reactions   Margarida Gonçalo

361

19

Pigmented Contact Dermatitis and Chemical Depigmentation   Hideo Nakayama

377

20

Hand Eczema   Tove Agner

395

21

Protein Contact Dermatitis   An Goossens and Cristina Amaro

407

22

Noneczematous Contact Reactions   Anthony Goon and Chee-Leok Goh

415

23

Respiratory Symptoms from Fragrances and the Link with Dermatitis   Jesper Elberling

429

PART V

DIAGNOSTIC TESTS

24

Patch Testing   Magnus Lindberg and Mihaly Matura

439

25

Atopy Patch Testing with Aeroallergens and Food Proteins   Ulf Darsow and Johannes Ring

465

26

Patch Testing in Adverse Drug Reactions   Margarida Gonçalo and Derk P. Bruynzeel

475

27

Allergens Exposure Assessment   Birgitta Gruvberger, Magnus Bruze, Sigfrid Fregert, and Carola Lidén

493

28

Skin Tests for Immediate Hypersensitivity   Carsten Bindslev-Jensen

511

29

Photopatch Testing   Margarida Gonçalo

519

30

Noninvasive Techniques for Quantification of Contact Dermatitis   Jørgen Serup

533

PART VI

ALLERGIC CONTACT DERMATITIS RELATED TO SPECIFIC EXPOSURES

31

Allergens from the European Baseline Series   Klaus E. Andersen, Ian R. White, and An Goossens

545

32

Cosmetics and Skin Care Products   Jonathan M.L. White, Anton C. de Groot, and Ian R. White

591

33

Fragrances   Jeanne Duus Johansen and Jean-Pierre Lepoittevin

607

34

Hair Dyes   David Basketter, Jeanne Duus Johansen, John McFadden, and Heidi Søsted

629

35

Metals   Carola Lidén, Magnus Bruze, Jacob Pontoppidan Thyssen, and Torkil Menné

643

36

Metalworking Fluids   Johannes Geier and Holger Lessmann

681

37

Plastic Materials   Bert Björkner, Malin Frick-Engfeldt, Ann Pontén, and Erik Zimerson

695

38

Topical Drugs   Francisco M. Brandão and An Goossens

729

39

Dental Materials   Marléne Isaksson

763

40

Clothing   Christophe-J. Le Coz

793

41

Shoes   An Goossens and James S. Taylor

819

42

Occupational Contact Dermatitis   Peter J. Frosch and Katrin Kügler

831

43

Occupational Contact Dermatitis: Health Personnel   Ana M. Giménez-Arnau

841

44

Occupational Contact Dermatitis: Chefs and Food Handlers   Vera Mahler

853

45

Occupational Contact Dermatitis: Hairdressers   Heidi Søsted

865

46

Plants and Plant Products   Christophe J. Le Coz, Georges Ducombs, and Evy Paulsen

873

47

Pesticides   Carola Lidén

927

48

Contact Allergy in Children   Marie-Anne Morren and An Goossens

937

49

Therapy and Rehabilitation of Allergic and Irritant Contact Dermatitis   Dimitar Antonov, Sibylle Schliemann, and Peter Eisner

963

50

Prevention of Hand Eczema: Gloves, Barrier Creams and Workers’ Education   Britta Wulfhorst, Meike Bock, Christoph Skudlik, Walter Wigger-Alberti, and Swen Make John

985

51

Prevention of Allergic Contact Dermatitis: Safe Exposure Levels of Sensitizers   Jacob Pontoppidan Thyssen and Torkil Menné

1017

52

Legislation   Ian R. White and David Basketter

1023

53

International Comparison of Legal Aspects of Workers’ Compensation for Occupational Contact Dermatitis   Peter J. Frosch, Werner Aberer, Paul J. August, Tove Agner, Lieve Constandt, L. Conde-Salazar, Swen M. John, Christophe Le Coz, Howard I. Maibach, Haydn L. Muston, Rosemary L. Nixon, Hanspeter Rast, W.I. van Tichelen, Jason Williams, Patricia Engasser, Felipe Heras, Magnus Lindberg, and Antti Laurema

1029

54

Databases and Networks. The Benefit of Research and Quality Assurance in Patch Testing   Wolfgang Uter, Axel Schnuch, Ana Giménez-Arnau, David Orton, and Barry Statham

1053

55

Contact Dermatitis Research Groups   Derk P. Bruynzeel

1065

56

Patch Test Concentrations and Vehicles for Testing Contact Allergens   Anton C. De Groot and Peter J. Frosch

1071

57

Patch Testing with the Patients’ Own Products   Peter J. Frosch, Johannes Geier, Wolfgang Uter, and An Goossens

1107

58

Dictionary of Contact Allergens: Chemical Structures, Sources, and References   Christophe J. Le Coz and Jean-Pierre Lepoittevin

1121

Index

1249