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Medicine > Genetics
Genome Plasticity in Health and Disease
Forero, Diego A.
ISBN 13: 
9780128178195
ISBN 10: 
0128178191
Category: 
Genetics
Edition: 
1
Publisher: 
Elsevier
Publication Date: 
06/2020
Format: 
Paperback
Status: 
Not Yet Published
Imprint: 
Academic Press
Audience: 
Professional and scholarly
Pages: 
312
Weight: 
2
Retail Price: 
175.00 (Tentative Price May Change)
Quantity On Hand: 
0
Quantity On Order: 
0
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Synopsis:

Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors, non-coding RNAs, telomere dynamics and RNA editing.

Later chapters explore disease relevance for cancer, as well as cardiovascular, neuropsychiatric, inflammatory, and endocrine disease, and associated pathways for drug discovery.



  • Examines the role of genome plasticity across a range of disease types, from cardiovascular disease, to cancer and neuropsychiatric disorders
  • Adopts an interdisciplinary approach, with expert contributions across the spectrum of basic science and disease relevance to drug discovery

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