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Book Detail
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Epigenetics in Organ Specific Disorders
Boosani, Chandra S.
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Doody’s Core Title Rating: 2.2 [Clinical Genetics] Audience: Professional and scholarly
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Synopsis:
Epigenetics in Organ Specific Disorders, a new volume in the Translational Epigenetics series, provides a foundational overview and nuanced analysis of epigenetic gene regulation distinct to each organ type and organ specific disorders, fully elucidating the epigenetics pathways that promote and regulate disease. After a brief introduction, chapter authors compare epigenetic regulations across normal and disease conditions in different organ tissues, exploring similarities and contrasts. The role of epigenetic mechanisms in stem cells, cell-matrix interactions and cell proliferation, cell migration, cellular apoptosis, necrosis, pyknosis, tumor suppression, and immune responses across different organ types are examined in-depth.
Organ specific epigenetic mechanisms and biomarkers of early use in developing drugs, which can selectively target the organ of interest, are also explored to enable new precision therapies.
- Identifies unique epigenetic mechanisms that occur in normal and disease conditions in each organ, examining differences and similarities
- Explores organ specific epigenetic mechanisms to enable drug discovery and development
- Features chapter contributions from leading researchers in the field
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