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Book Detail
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Handbook of Drug Metabolism
Woolf, Thomas
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Publisher: Taylor & Francis Affiliation: Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan, USA Audience: Professional and scholarly Dimensions: 10.0 x 1.3 x 7.0 in
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Synopsis:
Bringing together nearly forty collaborators from academic and industrial laboratories, this reference furnishes an overview of the subject in a historical, kinetic, and chemical context. A source of expertise for a rapidly changing and expanding field, the book provides a framework for drug metabolism in drug discovery and development. Containing tables, drawings, photographs, and equations, it highlights the importance of pharmacokinetics and cytochrome P450, explains clearance, volume of distribution, sequential metabolism, and nonlinear kinetics, summarizes concepts of Phase 1 and 2 metabolites, evaluates tertiary amine metabolism and reactive metabolite chemistry, and more.
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