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Medicine > Otorhinolaryngology
Molecular Diagnosis of Deafness
Usami, Shin-ichi
ISBN 13: 
9784431541738
ISBN 10: 
443154173X
Category: 
Otorhinolaryngology
Edition: 
1
Publisher: 
Springer
Publication Date: 
01/2021
Format: 
Cloth
Status: 
Not Yet Published
Imprint: 
Springer
Weight: 
2
Retail Price: 
129.00 (Tentative Price May Change)
Quantity On Hand: 
0
Quantity On Order: 
0
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Synopsis:
Genetic disorders are a common cause of congenital/early-onset sensorineural hearing loss. The identification of genes that are responsible for hearing loss is a breakthrough approach and has advanced our knowledge of the biology of hearing. Despite advances in the discovery of deafness genes, clinical application still presents problems because of the genetic heterogeneity of deafness. Genetic testing has become more important for highly accurate diagnosis, predicting the severity of hearing loss and associated abnormalities, selecting appropriate treatment options, preventing hearing loss, and better genetic counseling. In this book, the genes responsible for hearing loss will be reviewed, and a diagnostic strategy for mutation screening using a mutation/gene database based on the mutation spectrum of a corresponding population will be discussed. The simultaneous examination of the multiple deafness mutations by means of Invader assay followed by direct sequencing will enable us to detect deafness mutations in an efficient and practical manner for clinical use. We will also discuss the genetic background of the pre-lingual as well as post-lingual deafness patients with cochlear implantation. Furthermore, auditory performance after cochlear implantation will be reviewed in the patients who underwent genetic evaluation.

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